(v. t.) To reduce from a higher to a lower rank or degree; to lower in rank; to deprive of office or dignity; to strip of honors; as, to degrade a nobleman, or a general officer.
(v. t.) To reduce in estimation, character, or reputation; to lessen the value of; to lower the physical, moral, or intellectual character of; to debase; to bring shame or contempt upon; to disgrace; as, vice degrades a man.
(v. t.) To reduce in altitude or magnitude, as hills and mountains; to wear down.
(v. i.) To degenerate; to pass from a higher to a lower type of structure; as, a family of plants or animals degrades through this or that genus or group of genera.
Example Sentences:
(1) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(2) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
(5) Addition of extracellular mevalonate led to a concentration-dependent fall in both processes, although a higher concentration was required to produce the same effect on LDL degradation as on HMG-CoA reductase activity.
(6) Radioiodinated a-factor was used to identify the a-factor-degrading activity, which is cell associated, endoproteolytic, and not required for response to pheromone.
(7) Densitometric analysis of myofibrillar proteins separated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that troponin I and troponin T were degraded during 60 minutes of CGI.
(8) In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant.
(9) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(10) In vitro studies showed that BOF-A2 was rapidly degraded to EM-FU and CNDP in homogenates of the liver and small intestine of mice and rats, and in sera of mice, rats and human, and the conversion of EM-FU to 5-FU occurred only in the microsomal fraction of rat liver in the presence of NADPH.
(11) Only PPACK completely inhibited changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin.
(12) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(13) When cultures were pulse labeled for 15 min and then incubated under chase conditions for 105 min, the amount of degraded collagen attained a value equal to approximately 20% of the amount synthesized during the labeling period; the data were fit with a simple exponential function that had a 40-min rise time and a 12-min lag time.
(14) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(15) Degraded visual acuity had a significant effect on cadence, foot placement, and foot clearance, but visual surround conditions did not.
(16) The resistance of GSA 65 to proteolytic degradation, together with previous immunofluorescence data that indicate the antigen is an integral part of the G. lamblia cyst wall, suggests that this molecule may play a role in maintaining the integrity of the cyst in vivo.
(17) 5% of the degradation resulted from enzymatic activity in the culture medium, presumably due to secretion of proteolytic enzymes by the cells.
(18) At 37 degrees C, 125I-labeled TNF-alpha was rapidly internalized and degraded in L-929, U-937 and LAK cells.
(19) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(20) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.
Despise
Definition:
(v. t.) To look down upon with disfavor or contempt; to contemn; to scorn; to disdain; to have a low opinion or contemptuous dislike of.
Example Sentences:
(1) Indeed, it is democracy itself that the markets seem to despise.
(2) We were immediately sure he despised the movie more than any of the other Hollywood McCarthy adaptations – and there had been a few stinkers.
(3) Disowned by family and despised by public opinion, she is now in prison.
(4) The militant group, which despises foreign intervention, has expelled numerous international and local aid groups from the territory it controls.
(5) First, medicine was despised as a mechanical art or suspected of paganism because of its literary sources.
(6) How would you describe a person with an adoring sister and admiring father creating a child despised by father and siblings?
(7) In the wake of plunging costs in global market, prices on the forecourt have fallen much faster than household heating bills, which may be why petrol and oil companies are less despised than home energy suppliers – also being named by 26%.
(8) He has been derided in these pages, but that derision is surpassed by the venomous hatred of the Daily Mail , which loathes the Cameron government in any case and particularly despised Mitchell in his previous job.
(9) "I've always despised it to a certain degree but after this last few years and all this nonsense with the films, I believe it to be a completely poisonous place that isn't really going anywhere.
(10) Though he despised “race-baiting”, Noir wrote, “covert racism is a real thing and is very dangerous.
(11) So far, concerns about reproductions creeping on to the collectibles market seem greater than any worries about the reintroduction of objects that resurrect old, despised stereotypes.
(12) It's a melancholy fate for any writer to become an eponym for all that he despised, but that is what happened to George Orwell, whose memory is routinely abused in unthinking uses of the adjective "Orwellian".
(13) What an irony that our own MPs and peers, who complain so bitterly about the draining of British sovereignty to Brussels, were not trusted to discuss this issue – while the despised European parliament has, over the past year, freely, intelligently, intricately and repeatedly addressed it.
(14) The group despised the liberal socialism of the dominant Labour Zionists and its goal was an "Iron Wall" to defend Jews against what they deemed would be an inevitable backlash by Arabs.
(15) They were never aggressive, they were never forcing it down your throat … but you were left with no illusions looking at their social media that they were a) Chelsea fans and b) Ukip supporters.” He said he “despised” racism and described the actions on the film as appalling, adding that it in no way represented the views of most people at his former school.
(16) Vronsky, who had despised Karenin because he wouldn't fight a duel, is now humiliated and dishonoured; Karenin, flooded with forgiveness for everyone, wins back Anna's respect.
(17) He promised to take us "to the heart of Europe", but left behind a country more Europhobic than ever – and more despised in a Europe that he berated to appease Rupert Murdoch.
(18) They despised Bond's characters, his "slavishly literal bawdry", the lack of artistry in his writing.
(19) Malone, who was made a billionaire several times over by the AT&T deal, despised being answerable to the parent company's board and wanted out.
(20) Johnson was despised on the right and left by the time he was driven from office in 1968.