(v. t.) To reduce from a higher to a lower rank or degree; to lower in rank; to deprive of office or dignity; to strip of honors; as, to degrade a nobleman, or a general officer.
(v. t.) To reduce in estimation, character, or reputation; to lessen the value of; to lower the physical, moral, or intellectual character of; to debase; to bring shame or contempt upon; to disgrace; as, vice degrades a man.
(v. t.) To reduce in altitude or magnitude, as hills and mountains; to wear down.
(v. i.) To degenerate; to pass from a higher to a lower type of structure; as, a family of plants or animals degrades through this or that genus or group of genera.
Example Sentences:
(1) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(2) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
(5) Addition of extracellular mevalonate led to a concentration-dependent fall in both processes, although a higher concentration was required to produce the same effect on LDL degradation as on HMG-CoA reductase activity.
(6) Radioiodinated a-factor was used to identify the a-factor-degrading activity, which is cell associated, endoproteolytic, and not required for response to pheromone.
(7) Densitometric analysis of myofibrillar proteins separated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that troponin I and troponin T were degraded during 60 minutes of CGI.
(8) In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant.
(9) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(10) In vitro studies showed that BOF-A2 was rapidly degraded to EM-FU and CNDP in homogenates of the liver and small intestine of mice and rats, and in sera of mice, rats and human, and the conversion of EM-FU to 5-FU occurred only in the microsomal fraction of rat liver in the presence of NADPH.
(11) Only PPACK completely inhibited changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin.
(12) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(13) When cultures were pulse labeled for 15 min and then incubated under chase conditions for 105 min, the amount of degraded collagen attained a value equal to approximately 20% of the amount synthesized during the labeling period; the data were fit with a simple exponential function that had a 40-min rise time and a 12-min lag time.
(14) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(15) Degraded visual acuity had a significant effect on cadence, foot placement, and foot clearance, but visual surround conditions did not.
(16) The resistance of GSA 65 to proteolytic degradation, together with previous immunofluorescence data that indicate the antigen is an integral part of the G. lamblia cyst wall, suggests that this molecule may play a role in maintaining the integrity of the cyst in vivo.
(17) 5% of the degradation resulted from enzymatic activity in the culture medium, presumably due to secretion of proteolytic enzymes by the cells.
(18) At 37 degrees C, 125I-labeled TNF-alpha was rapidly internalized and degraded in L-929, U-937 and LAK cells.
(19) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(20) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.
Disgrace
Definition:
(n.) The condition of being out of favor; loss of favor, regard, or respect.
(n.) The state of being dishonored, or covered with shame; dishonor; shame; ignominy.
(n.) That which brings dishonor; cause of shame or reproach; great discredit; as, vice is a disgrace to a rational being.
(n.) An act of unkindness; a disfavor.
(n.) To put out favor; to dismiss with dishonor.
(n.) To do disfavor to; to bring reproach or shame upon; to dishonor; to treat or cover with ignominy; to lower in estimation.
(n.) To treat discourteously; to upbraid; to revile.
Example Sentences:
(1) The speech also made a reference to the disgraced former cabinet minister Chris Huhne, with Ashdown telling delegates that when he first stood for parliament in Yeovil in the 1970s, the Liberal leader at the time, Jeremy Thorpe, was facing trial at the Old Bailey.
(2) As the Labour leadership accused the coalition of launching a smear campaign over the party's links with the disgraced chairman, a transcript of an interview with Balls in 2010 showed that he highlighted his role in helped to create Britain's "first ever 'super-mutual'".
(3) Miliband – sounding more animated than normal – hit back at the prime minister, saying: "What an absolute disgrace to describe talking about cancer patients in this country as a smokescreen."
(4) Silfen told Haaretz: “I missed a critical committee session that I needed to attend and was sent home in disgrace because the length of my dress didn’t suit them.
(5) 'Have a thick skin' – sex discrimination commissioner's advice to her successor Read more Labor said it was “a disgrace for women everywhere” that the government was delaying appointing a replacement for Elizabeth Broderick, the long-serving commissioner whose term expired four months ago.
(6) But it is the presence of Webb on the list that is potentially most troubling for Blatter, who has been at Fifa for 40 years since moving from watchmaker Longines to become the protege of his now disgraced predecessor João Havelange.
(7) One particular poem attacked by Liao, he said, is not praising a disgraced party official, but is actually satire.
(8) Disgraced former Labour MP Eric Joyce, who assaulted a colleague in a Commons bar in 2012, had his card blocked when he owed £12,919.61, and later had his salary docked.
(9) In a swipe at Corbyn, Scottish Labour leader Kezia Dugdale, addressing the meeting, said: “Never forget, the best way to represent and deliver for working people will always be from the government benches.” After the meeting, the former Labour MP Lord Watts confronted Seumas Milne, Corbyn’s head of communications, and told him he was “a disgrace”.
(10) Mohamed Bin Hammam, the disgraced former president of the Asian Football Confederation, has been linked to paying a string of bribes during the Qatari’s failed bid to become Fifa president, with some linking his activities to the concurrent Qatar 2022 bid.
(11) The wife of disgraced Chinese politician Bo Xilai was spared execution at a hearing last week, with a court in Hefei instead handing her the suspended penalty .
(12) After this disgraceful farce of wrongful blame (the spokespeople for the police and the NHS happy to tolerate, if not encourage, the misleading targeting of the social workers), the right questions are still being ignored.
(13) In the Commons, John McDonnell, the MP for Hayes and Harlington, covering Heathrow, was suspended for five days by the deputy speaker after he picked up the mace and shouted: "It is a disgrace."
(14) The extent and depth of political bias in the BBC is a matter of opinion, but this is a disgrace by any standard, however low.
(15) The bill was assisted along its way by the fact that one of its most prominent opponents was disgraced Cardinal Keith O'Brien .
(16) Analysts say Kim Jong-un, North Korea’s dictator, is waiting to see how the Trump administration shapes up and who replaces South Korea’s disgraced president, Park Geun-hye.
(17) At his presidential announcement last week, former Texas governor Rick Perry called the withdrawal from Iraq “a national disgrace” and argued that the US had “won” the war in 2009 only to see the Obama administration squander its victory by leaving.
(18) The senior Tory has acknowledged he became heated after he was seen shouting "you're a disgrace" at Tories and Liberal Democrats who failed to vote with the government.
(19) Speaking from her home in New Jersey, she said: "Any letting out of Megrahi would be a disgrace.
(20) Blood laced with disgrace flows from my hands, feet and side.