(v. t.) To reduce from a higher to a lower rank or degree; to lower in rank; to deprive of office or dignity; to strip of honors; as, to degrade a nobleman, or a general officer.
(v. t.) To reduce in estimation, character, or reputation; to lessen the value of; to lower the physical, moral, or intellectual character of; to debase; to bring shame or contempt upon; to disgrace; as, vice degrades a man.
(v. t.) To reduce in altitude or magnitude, as hills and mountains; to wear down.
(v. i.) To degenerate; to pass from a higher to a lower type of structure; as, a family of plants or animals degrades through this or that genus or group of genera.
Example Sentences:
(1) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(2) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
(5) Addition of extracellular mevalonate led to a concentration-dependent fall in both processes, although a higher concentration was required to produce the same effect on LDL degradation as on HMG-CoA reductase activity.
(6) Radioiodinated a-factor was used to identify the a-factor-degrading activity, which is cell associated, endoproteolytic, and not required for response to pheromone.
(7) Densitometric analysis of myofibrillar proteins separated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that troponin I and troponin T were degraded during 60 minutes of CGI.
(8) In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant.
(9) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(10) In vitro studies showed that BOF-A2 was rapidly degraded to EM-FU and CNDP in homogenates of the liver and small intestine of mice and rats, and in sera of mice, rats and human, and the conversion of EM-FU to 5-FU occurred only in the microsomal fraction of rat liver in the presence of NADPH.
(11) Only PPACK completely inhibited changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin.
(12) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(13) When cultures were pulse labeled for 15 min and then incubated under chase conditions for 105 min, the amount of degraded collagen attained a value equal to approximately 20% of the amount synthesized during the labeling period; the data were fit with a simple exponential function that had a 40-min rise time and a 12-min lag time.
(14) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(15) Degraded visual acuity had a significant effect on cadence, foot placement, and foot clearance, but visual surround conditions did not.
(16) The resistance of GSA 65 to proteolytic degradation, together with previous immunofluorescence data that indicate the antigen is an integral part of the G. lamblia cyst wall, suggests that this molecule may play a role in maintaining the integrity of the cyst in vivo.
(17) 5% of the degradation resulted from enzymatic activity in the culture medium, presumably due to secretion of proteolytic enzymes by the cells.
(18) At 37 degrees C, 125I-labeled TNF-alpha was rapidly internalized and degraded in L-929, U-937 and LAK cells.
(19) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(20) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.
Extenuate
Definition:
(v. t.) To make thin or slender; to draw out so as to lessen the thickness.
(v. t.) To lessen; to palliate; to lessen or weaken the force of; to diminish the conception of, as crime, guilt, faults, ills, accusations, etc.; -- opposed to aggravate.
(v. t.) To lower or degrade; to detract from.
(v. i.) To become thinner; to make excuses; to advance palliating considerations.
(a.) Thin; slender.
Example Sentences:
(1) Can't put a finger on it, though there were obvious extenuating personal circumstances in the case of the two most anticipated acts (Gaga and Cole).
(2) It is our opinion that except for certain extenuating circumstances, the procedure of choice for carcinoma of the breast is either a modified or standard radical mastectomy.
(3) These negative feelings and negative self-images are exploited so as to appease the superego in the face of one's hostile aggression: that one is justified, that there are extenuating circumstances for one's hatred and destructiveness.
(4) Other recent IOM research shows that the majority had not intended to travel to Europe when leaving home, but had been forced to change their destinations due to extenuating circumstances such as the Libyan civil war.
(5) The intravenous urogram, including the initial plain film, remains the primary diagnostic modality and, in the absence of extenuating clinical features, is often the sole test required to make a decision regarding the best therapeutic modality.
(6) Uruguay recently legalised first trimester interventions, while Colombia, Brazil and Argentina allow abortion in rape and other extenuating circumstances.
(7) "What I am saying is that I don't think everyone should be chucked into prison regardless of the circumstances, with no discretion, no exceptions and no extenuating circumstances.
(8) Thirdly, it starts to admit extenuations and exceptions.
(9) These changes develop by an increase in mean arterial pressure, the reduction of the sympathetic activity, and probably of an extenuation of the splanchnic vasodilation.
(10) Hence, chronic administration of lithium leads to potentiation in its action of the serotonin-negative and central adreno-negative componets and to extenuating the peripheral adreno-negative component.
(11) "Due to extenuating circumstances, Secret Cinema is unable to receive guests at tonight's show of Secret Cinema presents Back to the Future" the statement read.
(12) The government already has precious little trust in grassroots British Muslim circles on their preventing extremism agenda – and if the suggested plans are true then that disconnect will simply extenuate the circumstances, making us all that much less safe.
(13) Subjects' rating indicated that (a) biology was judged important for explaining negative moods occurring premenstrually: (b) inconsistency between mood and environment produced more internal (personality) attributions, while consistency enhanced external attributions; and (c) emotionally expressive behavior was thought to reflect underlying personality dispositions despite extenuating situational factors (assumed personal causation).
(14) Both had very extenuating circumstances making complete repair inappropriate.
(15) Adam's sin is perhaps mitigated by the extenuating circumstance that he didn't exist.
(16) The population studies as representative of psychiatric extenuation are a personal consecutive sample of court referrals for formal evaluation undertaken in a psychiatric hospital unit.
(17) Only extenuating circumstances justify these risks when general anesthesia is available.
(18) In some cases, there were extenuating circumstances which, when combined with obstetrical intervention, resulted in an increase in mortality.
(19) Secret Cinema said that the cancellation was due to "extenuating circumstances".
(20) The 49ers are in his backyard.” Martin must pass a physical for the trade to be officially executed, but that’s expected for be a formality for the 42nd overall pick in the 2012 draft, who will now hope to fulfil his potential in a new environment after underperforming - albeit with extenuating circumstances - in Miami.