(v. t.) To reduce from a higher to a lower rank or degree; to lower in rank; to deprive of office or dignity; to strip of honors; as, to degrade a nobleman, or a general officer.
(v. t.) To reduce in estimation, character, or reputation; to lessen the value of; to lower the physical, moral, or intellectual character of; to debase; to bring shame or contempt upon; to disgrace; as, vice degrades a man.
(v. t.) To reduce in altitude or magnitude, as hills and mountains; to wear down.
(v. i.) To degenerate; to pass from a higher to a lower type of structure; as, a family of plants or animals degrades through this or that genus or group of genera.
Example Sentences:
(1) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(2) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
(5) Addition of extracellular mevalonate led to a concentration-dependent fall in both processes, although a higher concentration was required to produce the same effect on LDL degradation as on HMG-CoA reductase activity.
(6) Radioiodinated a-factor was used to identify the a-factor-degrading activity, which is cell associated, endoproteolytic, and not required for response to pheromone.
(7) Densitometric analysis of myofibrillar proteins separated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that troponin I and troponin T were degraded during 60 minutes of CGI.
(8) In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant.
(9) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(10) In vitro studies showed that BOF-A2 was rapidly degraded to EM-FU and CNDP in homogenates of the liver and small intestine of mice and rats, and in sera of mice, rats and human, and the conversion of EM-FU to 5-FU occurred only in the microsomal fraction of rat liver in the presence of NADPH.
(11) Only PPACK completely inhibited changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin.
(12) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(13) When cultures were pulse labeled for 15 min and then incubated under chase conditions for 105 min, the amount of degraded collagen attained a value equal to approximately 20% of the amount synthesized during the labeling period; the data were fit with a simple exponential function that had a 40-min rise time and a 12-min lag time.
(14) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(15) Degraded visual acuity had a significant effect on cadence, foot placement, and foot clearance, but visual surround conditions did not.
(16) The resistance of GSA 65 to proteolytic degradation, together with previous immunofluorescence data that indicate the antigen is an integral part of the G. lamblia cyst wall, suggests that this molecule may play a role in maintaining the integrity of the cyst in vivo.
(17) 5% of the degradation resulted from enzymatic activity in the culture medium, presumably due to secretion of proteolytic enzymes by the cells.
(18) At 37 degrees C, 125I-labeled TNF-alpha was rapidly internalized and degraded in L-929, U-937 and LAK cells.
(19) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(20) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.
Shame
Definition:
(n.) A painful sensation excited by a consciousness of guilt or impropriety, or of having done something which injures reputation, or of the exposure of that which nature or modesty prompts us to conceal.
(n.) Reproach incurred or suffered; dishonor; ignominy; derision; contempt.
(n.) The cause or reason of shame; that which brings reproach, and degrades a person in the estimation of others; disgrace.
(n.) The parts which modesty requires to be covered; the private parts.
(v. t.) To make ashamed; to excite in (a person) a comsciousness of guilt or impropriety, or of conduct derogatory to reputation; to put to shame.
(v. t.) To cover with reproach or ignominy; to dishonor; to disgrace.
(v. t.) To mock at; to deride.
(n.) To be ashamed; to feel shame.
Example Sentences:
(1) Stray bottles were thrown over the barriers towards officers to cheers and chants of: “Shame on you, we’re human too.” The Met deployed what it described as a “significant policing operation”, including drafting in thousands of extra officers to tackle expected unrest, after previous events ended in arrests and clashes with police across the centre of the capital.
(2) The Bible treats suicide in a factual way and not as wrong or shameful.
(3) However, there's been very little mention of what happened in Manchester today – shame on you.
(4) There can’t be something, someone that could fix this and chooses not to.” Years of agnosticism and an open attitude to religious beliefs thrust under the bus, acknowledging the shame that comes from sitting down with those the world forgot.
(5) Yogi Breisner, performance manager for the British eventing team, said: "It is a real shame that it has been called off, especially in an Olympic year when a lot of the riders and horses would have been on show.
(6) The irony of this type of self-manipulation is that ultimately the child, or adult, finds himself again burdened by impotence, though it is the impotence of guilt rather than that of shame.
(7) "The whole thing was stupid, Donald called him at once to discuss it, he had such a go at him, I mean, fuck, it's a shame we didn't record it, he fucked him up good, had such a proper fucking go at him."
(8) Significant differences (p less than 0.05-p less than 0.01) were found, suggesting that the Eastern mothers strongly expressed their shame, whereas the Western mothers 'felt ashamed' to express it at all.
(9) For now, the overriding feeling is helplessness, tinged with shame for the last year of passivity.
(10) He was looking down at his feet - and she realised he felt the shame, too.
(11) Frankly, it is rather a shame that he does not fall under the Treasure Act (to do so he would have to be over 300 years old and be composed of more than 10% gold or silver).
(12) I look back at those moments with shame – you look to your parents to protect you so, when it seems they are falling apart, you lash out at them because you feel vulnerable.
(13) We wanted a place where men could discuss masculine topics without facing the same public shaming outcry that happens on social media sites – feminists are quick on the trigger to try to take down anything they consider wrong … Milo Yiannopoulos lost his verified status on Twitter because of his views on masculinity.
(14) Digital culture has hardly helped, adding revenge porn, trolls and stranger-shaming to the list of uncomfortable modern obstacles.
(15) A boss on some astronomic pay packet may be held back by shame from paying his cleaners too little relative to that, but emotion will not get in the way of ruthlessness if the process all takes place behind the veil of some corporate contract.
(16) "The house itself isn't very old ... it's a great shame."
(17) This year, on the first day, I bumped into a fellow market regular who was hawking a DVD title (no longer a badge of shame).
(18) Reda Eldanbouki, director of the women’s centre for guidance and legal awareness, an Egyptian NGO based in al-Mansoura, said it was shameful for Hijazi to ask the eight presenters to only come back in front of camera once their appearance has become “appropriate”.
(19) I got a hint of the price she has paid for her ambidextrous approach to cultural identify after her last interview was published, when a shocking number of British Pakistani men got in touch to denounce her as a shameful infidel.
(20) He said similar “name and shame” legislation had run afoul of the first amendment and that the rule may be unconstitutional.