(a.) Reduced in rank, character, or reputation; debased; sunken; low; base.
(a.) Having the typical characters or organs in a partially developed condition, or lacking certain parts.
(a.) Having steps; -- said of a cross each of whose extremities finishes in steps growing larger as they leave the center; -- termed also on degrees.
Example Sentences:
(1) This bone could not be degraded by human monocytes in vitro as well as control bone (only 54% of control; P less than 0.003).
(2) Lp(a) also complexes to plasmin-fibrinogen digests, and binding increases in proportion to the time of plasmin-induced fibrinogen degradation.
(3) The rate of accumulation of degraded LDL products was lower in collagen gel cultures, but the final levels achieved were the same in the two substrata.
(4) At the highest dose of chloroquine tested (500 microM), a slightly greater increase in insulin binding and a decrease in insulin degradation were observed in fetal cells as compared with adult cells.
(5) Addition of extracellular mevalonate led to a concentration-dependent fall in both processes, although a higher concentration was required to produce the same effect on LDL degradation as on HMG-CoA reductase activity.
(6) Radioiodinated a-factor was used to identify the a-factor-degrading activity, which is cell associated, endoproteolytic, and not required for response to pheromone.
(7) Densitometric analysis of myofibrillar proteins separated with sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicated that troponin I and troponin T were degraded during 60 minutes of CGI.
(8) In addition, we found apyrase activity (which degrades ATP and ADP to AMP and orthophosphate) and an anticoagulant.
(9) Degradation of both viral and host DNA with micrococcal nuclease and spleen phosphodiesterase indicated that CdG was incorporated primarily into internal positions in both DNAs.
(10) In vitro studies showed that BOF-A2 was rapidly degraded to EM-FU and CNDP in homogenates of the liver and small intestine of mice and rats, and in sera of mice, rats and human, and the conversion of EM-FU to 5-FU occurred only in the microsomal fraction of rat liver in the presence of NADPH.
(11) Only PPACK completely inhibited changes in fibrin degradation products, plasminogen and alpha 2-antiplasmin.
(12) On the other hand, if we correct for the population of HMM with degraded light chain 2, the difference in the binding constants in the presence and absence of Ca2+ may be as great as 5-fold.
(13) When cultures were pulse labeled for 15 min and then incubated under chase conditions for 105 min, the amount of degraded collagen attained a value equal to approximately 20% of the amount synthesized during the labeling period; the data were fit with a simple exponential function that had a 40-min rise time and a 12-min lag time.
(14) The mode of ribosome degradation under this condition is discussed in terms of differential appearance of these intermediate particles.
(15) Degraded visual acuity had a significant effect on cadence, foot placement, and foot clearance, but visual surround conditions did not.
(16) The resistance of GSA 65 to proteolytic degradation, together with previous immunofluorescence data that indicate the antigen is an integral part of the G. lamblia cyst wall, suggests that this molecule may play a role in maintaining the integrity of the cyst in vivo.
(17) 5% of the degradation resulted from enzymatic activity in the culture medium, presumably due to secretion of proteolytic enzymes by the cells.
(18) At 37 degrees C, 125I-labeled TNF-alpha was rapidly internalized and degraded in L-929, U-937 and LAK cells.
(19) Recovery after EEDQ administration showed that both receptor production rate and degradation rate constants of anterior pituitary D2 and striatal D1 receptors were slowed after chronic estradiol treatment, whereas recovery rates for striatal D2 dopamine receptors were unaffected.
(20) The specific rates of degradation of L-arginine-AMC, gly-proline-AMC, N-alpha-benzoyl-L-arginine-AMC and N-[p-toluene-sulphonyl]gly-pro-arginine-AMC were significantly greater in that group, indicating that the composition of their gingival crevicular fluid was different from that of the gingivitis group.
Step
Definition:
(a.) To move the foot in walking; to advance or recede by raising and moving one of the feet to another resting place, or by moving both feet in succession.
(a.) To walk; to go on foot; esp., to walk a little distance; as, to step to one of the neighbors.
(a.) To walk slowly, gravely, or resolutely.
(a.) Fig.: To move mentally; to go in imagination.
(v. t.) To set, as the foot.
(v. t.) To fix the foot of (a mast) in its step; to erect.
(v. i.) An advance or movement made by one removal of the foot; a pace.
(v. i.) A rest, or one of a set of rests, for the foot in ascending or descending, as a stair, or a round of a ladder.
(v. i.) The space passed over by one movement of the foot in walking or running; as, one step is generally about three feet, but may be more or less. Used also figuratively of any kind of progress; as, he improved step by step, or by steps.
(v. i.) A small space or distance; as, it is but a step.
(v. i.) A print of the foot; a footstep; a footprint; track.
(v. i.) Gait; manner of walking; as, the approach of a man is often known by his step.
(v. i.) Proceeding; measure; action; an act.
(v. i.) Walk; passage.
(v. i.) A portable framework of stairs, much used indoors in reaching to a high position.
(v. i.) In general, a framing in wood or iron which is intended to receive an upright shaft; specif., a block of wood, or a solid platform upon the keelson, supporting the heel of the mast.
(v. i.) One of a series of offsets, or parts, resembling the steps of stairs, as one of the series of parts of a cone pulley on which the belt runs.
(v. i.) A bearing in which the lower extremity of a spindle or a vertical shaft revolves.
(v. i.) The intervak between two contiguous degrees of the csale.
(v. i.) A change of position effected by a motion of translation.
Example Sentences:
(1) These data suggest that the hybrid is formed by the same mechanism in the absence and presence of the urea step.
(2) That means deciding what job they’d like to have and outlining the steps they’ll need to take to achieve it.
(3) Enhanced sensitivity to ITDs should translate to better-defined azimuthal receptive fields, and therefore may be a step toward achieving an optimal representation of azimuth within the auditory pathway.
(4) Nucleotide, which is essential for catalysis, greatly enhances the binding of IpOHA by the reductoisomerase, with NADPH (normally present during the enzyme's rearrangement step, i.e., conversion of a beta-keto acid into an alpha-keto acid, in either the forward or reverse physiological reactions) being more effective than NADP.
(5) Training in social skills specific to fostering intimacy is suggested as a therapeutic step, and modifications to the social support measure for future use discussed.
(6) To explore an early step, we synthesized 5 beta-cholest-7-ene-3 beta,6 alpha,14 alpha-triol in tritiated form.
(7) Change of steps in achieved just by varying the reaction conditions without any product purification.
(8) Yesterday's flight may not quite have been one small step for man, but the hyperbole and the sense of history weighed heavily on those involved.
(9) After immunoadsorbent purification, the final step in a purification procedure similar to that adopted for colon cancer CEA, two main molecular species were identified: 1) Material identical with colon cancer CEA with respect to molecular size, PCA solubility, ability to bind to Con A, and most important the ability to bind to specific monkey anti-CEA serum.
(10) The stepped approach is cost-effective and provides an objective basis for decisions and priority setting.
(11) "These developments are clearly unwarranted on the basis of economic and budgetary fundamentals in these two member states and the steps that they are taking to reinforce those fundamentals."
(12) We describe both the three supportive psychotherapeutic steps, which may last months to years including subsequent dynamically psychotherapeutic strategies as well as the reactions of the auxiliary therapist function on the students.
(13) It is also a clear sign of our willingness and determination to step up engagement across the whole range of the EU-Turkey relationship to fully reflect the strategic importance of our relations.
(14) As calls grew to establish why nobody stepped in to save Daniel, it was also revealed that the boy's headteacher – who saw him scavenging for scraps – has not been disciplined and has been put in charge of a bigger school.
(15) Problem definition, the first step in policy development, includes identifying the issues, discussing and framing the issues, analyzing data and resources, and deciding on a problem definition.
(16) The influence of vestibular dysfunction upon the vestibulospinal reflex (VSR) in two common peripheral syndromes was investigated by two types of posturographic examination: "static" posturography, recording and analyzing the postural sway in stance, and "kinetic" posturography, recording the stepping in place test.
(17) The second step occurs several hours later and consists of the transactivation of adenylate cyclase and pertussis toxin genes.
(18) Western diplomats acknowledge that the capture of Qusair is likely to have emboldened President Bashar al-Assad , making him less likely to consider concessions – let alone stepping down.
(19) The influence of exogenous mitogens (RFG, TGF beta 1 and insulin) and autocrine factor (at different step of purification) on the growth of Morris hepatoma 7777 (MH) cells was estimated by both methods.
(20) An experience in working out and introduction of a system of failure-free performance work as one of the most important steps in creating a complex system for the production quality control at the Leningrad combine "Krasnogvardeets" is described.