(v. t.) To render unnatural; to alienate from nature.
(v. t.) To renounce the natural rights and duties of; to deprive of citizenship; to denationalize.
Example Sentences:
(1) DNA in situ is progressively denatured when the cells or nuclei are treated with increasing concentration of acridine orange (AO).
(2) We propose that during the detergent solubilization the acidic phospholipids protect the transport systems against denaturation by preventing delipidation.
(3) Denaturation studies demonstrated that less than 50% of protein content of C. psittaci was denatured after 1 h of sonication, only 5% in the case of C. trachomatis.
(4) Our results also showed a good correlation between the importance of deposits and the presence of denatured DNA-anti-denatured-DNA circulating complexes.
(5) Refolding was observed by injection of denatured protein into columns having isocratic concentrations in the transition and native base-line zones.
(6) Extraction of liposomes containing guanylate cyclase with 0.2% Lubrol PX resulted in the recovery of 85% of the original amount of added activity, suggesting that the decrease in maximal velocity was not due to enzyme denaturation.
(7) Single-stranded circles did not form if a limited number of nucleotides were removed from the 3' ends of native molecules by Escherichia coli exonuclease III digestion prior to denaturation and annealing.
(8) Denatured DNA and histones were inhibitory, but native DNA and its histone complex were not inhibitory.
(9) Both enzymes are capable of catalyzing the refolding of thermally denatured type III collagen.
(10) We investigated the denaturation of tetrameric 20 beta-hydroxysteroid dehydrogenase (20R)-17 beta,20 beta,21-trihydroxysteroid:NAD+ oxidoreductase, EC 1.1.1.53) to find out whether intermediate states are formed during the process.
(11) Thermal-denaturation studies showed that this bromoperoxidase could tolerate high temperatures.
(12) Pig kidney extracts have been partially purified by thermal denaturation and chromatography on Sephadex G-200 and D.E.A.E.
(13) RNA transcribed by RNA polymerase II on denatured DNA was only large RNA around 28S.
(14) The differential scanning calorimetry (DSC) studies demonstrate an increased susceptibility of the Ala 183----Pro mutant to thermal denaturation.
(15) The secreted antibody, which can be readily purified from the media without any denaturation or renaturation steps, retains antigen-binding activity.
(16) The electrophoretic pattern of free radical-exposed FABP was not markedly different when examined either by the non-denaturing or by denaturing PAGE, suggesting the absence of any degradation or aggregation of FABP by O2- or OH..
(17) Synthesis with denatured DNA as template presumably proceeds from 3'-hydroxyl termini formed at loop-back regions since the synthesized DNA product and template are covalently linked.
(18) Multiple contacts between the gamma-subunit and calmodulin (delta-subunit), as indicated by our data, may help to explain why strongly denaturing conditions are required to dissociate these two subunits, whereas complexes of calmodulin with most other target enzymes can be readily dissociated by merely lowering Ca2+ to submicromolar concentrations.
(19) Heating is shown to bring about only the denaturation of protein molecules in crystals.
(20) Renal tissues from two groups of patients were studied with fluorescein-labeled (Fl-) antibodies (Abs) to immunoglobulins, complement, and antibodies prepared in rabbits against BSA conjugate of 5-methyluridine (T) and cytidine (C), the latter two of which react specifically with denatured DNA.
Natural
Definition:
(a.) Fixed or determined by nature; pertaining to the constitution of a thing; belonging to native character; according to nature; essential; characteristic; not artifical, foreign, assumed, put on, or acquired; as, the natural growth of animals or plants; the natural motion of a gravitating body; natural strength or disposition; the natural heat of the body; natural color.
(a.) Conformed to the order, laws, or actual facts, of nature; consonant to the methods of nature; according to the stated course of things, or in accordance with the laws which govern events, feelings, etc.; not exceptional or violent; legitimate; normal; regular; as, the natural consequence of crime; a natural death.
(a.) Having to do with existing system to things; dealing with, or derived from, the creation, or the world of matter and mind, as known by man; within the scope of human reason or experience; not supernatural; as, a natural law; natural science; history, theology.
(a.) Conformed to truth or reality
(a.) Springing from true sentiment; not artifical or exaggerated; -- said of action, delivery, etc.; as, a natural gesture, tone, etc.
(a.) Resembling the object imitated; true to nature; according to the life; -- said of anything copied or imitated; as, a portrait is natural.
(a.) Having the character or sentiments properly belonging to one's position; not unnatural in feelings.
(a.) Connected by the ties of consanguinity.
(a.) Begotten without the sanction of law; born out of wedlock; illegitimate; bastard; as, a natural child.
(a.) Of or pertaining to the lower or animal nature, as contrasted with the higher or moral powers, or that which is spiritual; being in a state of nature; unregenerate.
(a.) Belonging to, to be taken in, or referred to, some system, in which the base is 1; -- said or certain functions or numbers; as, natural numbers, those commencing at 1; natural sines, cosines, etc., those taken in arcs whose radii are 1.
(a.) Produced by natural organs, as those of the human throat, in distinction from instrumental music.
(a.) Of or pertaining to a key which has neither a flat nor a sharp for its signature, as the key of C major.
(a.) Applied to an air or modulation of harmony which moves by easy and smooth transitions, digressing but little from the original key.
(n.) A native; an aboriginal.
(n.) Natural gifts, impulses, etc.
(n.) One born without the usual powers of reason or understanding; an idiot.
(n.) A character [/] used to contradict, or to remove the effect of, a sharp or flat which has preceded it, and to restore the unaltered note.
Example Sentences:
(1) The results indicated that neuropsychological measures may serve to broaden the concept of intelligence and that a brain-related criterion may contribute to a fuller understanding of its nature.
(2) In Patient 2 they were at first paroxysmal and unformed, with more prolonged metamorphopsia; later there appeared to be palinoptic formed images, possibly postictal in nature.
(3) We conclude that the priming effect is not a clinically significant phenomenon during natural pollen exposure in allergic rhinitis patients.
(4) Quantitative determinations indicate that the amount of PBG-D mRNA is modulated both by the erythroid nature of the tissue and by cell proliferation, probably at the transcriptional level.
(5) The severity and site of hypertrophy is important in determining the clinical picture and the natural history of hypertrophic cardiomyopathy (HCM).
(6) Here, we review the nature of the heart sound signal and the various signal-processing techniques that have been applied to PCG analysis.
(7) To investigate the immunomodulating properties of cis-diamminedichloroplatinum (II) (CDDP), we studied the drug's effects on natural killer (NK) lymphocyte cytotoxicity.
(8) Examined specific relationships, as they occur in nature, between particular dietary variables or groups of variables and specific MMPI subscales.
(9) Natural tubulin polymerization leads to the formation of hooks on microtubular structures.
(10) Trichostatin C is presumably the first example of a glucopyranosyl hydroxamate from nature.
(11) The present study was undertaken to find out the nature of enzymes responsible for the processing of DV antigen in M phi.
(12) The cyclical nature of pyromania has parallels in cycles of reform in standards of civil commitment (Livermore, Malmquist & Meehl, 1958; Dershowitz, 1974), in the use of physical therapies and medications (Tourney, 1967; Mora, 1974), in treatment of the chronically mentally ill (Deutsch, 1949; Morrissey & Goldman, 1984), and in institutional practices (Treffert, 1967; Morrissey, Goldman & Klerman (1980).
(13) The nature of the putative autoantigen in Graves' ophthalmopathy (Go) remains an enigma but the sequence similarity between thyroglobulin (Tg) and acetylcholinesterase (ACHE) provides a rationale for epitopes which are common to the thyroid gland and the eye orbit.
(14) Further exploration of these excretory pathways will provide interesting new insights on the numerous cholestatic and hyperbilirubinemic syndromes that occur in nature.
(15) In this way they offer the doctor the chance of preventing genetic handicaps that cannot be obtained by natural reproduction, and that therefore should be used.
(16) The nature, intracellular distribution, and role of proteins synthesized during meiotic maturation of mouse oocytes in vitro have been examined.
(17) Natural killer cells (CD8+CD57+) as well as activated T cells (CD3+HLA-DR+) were significantly increased in patients with sarcoidosis.
(18) In certain cases, the effects of these substances are enhanced, in others, they are inhibited by compounds that were isolated from natural sources or prepared by chemical synthesis.
(19) Analysis of 156 records relating to patients at the age of 15 to 85 years with extended purulent peritonitis of the surgical and gynecological genesis (the toxic phase, VI category ASA) showed that combination of programmed sanitation laparotomy and intensive antibacterial therapy performed as short-term courses before, during and after the operation with an account of the information on the nature of the microbial associations and antibioticograms was an efficient procedure in treatment of severe peritonitis.
(20) There is no convincing evidence that immunosuppression is effective, also because the natural history of the disease is characterised by a spontaneous disappearance of the factor VIII-C inhibitor.