(1) The nitrate metabolites showed sustained plasma profiles which can be explained by a slow release of GTN with subsequent complete first-pass denitration.
(2) Esophageal responses in normal subjects with water at the two temperatures were not affected by isosorbide denitrate.
(3) These data suggest that vascular GTN metabolism in BCA is carried out by cytosolic GST isozymes which possess a preference for C-2 denitration of GTN.
(4) The rate of denitration at each nitro group in ISDN was almost twice as high as for the same position in the corresponding mononitrate.
(5) The denitrate derivatives of KRN2391 are specific K channel openers.
(6) Denitration of organic nitrates by the microsomal fraction of rat liver was NADPH dependent and followed apparent first-order kinetics.
(7) 6:1, representing a highly selective if not specific primary denitration of the 1,2-GDN molecule.
(8) In the current study, we assessed the involvement of cytochrome P-450 in the denitration of glyceryl trinitrate and the enantiomers of isoidide dinitrate.
(9) Nitroglycerin and other organic nitrate esters elicit endothelium-independent relaxation after entering vascular smooth muscle cells and undergoing denitration and formation of NO.
(10) The individual roles of the denitrated metabolites in nitrate tolerance are still unclear.
(11) The pharmacokinetics of glyceryl trinitrate are complex and only 1% of the drug administered orally can be detected in the plasma due to a pronounced arteriovenous concentration gradient, hydrolysis in the blood, and rapid denitration in the liver.
(12) Rat liver microsomes catalyze the oxidative denitration of N omega-hydroxy-L-arginine (NOHA) by NADPH and O2 with formation of citrulline and nitrogen oxides like NO and NO2-.
(13) The highest activity was obtained under anaerobic conditions and the reaction was inhibited by O2 indicating that it is a reductive denitration.
(14) Enzymatic denitration occurs not only in the liver, but also in blood and other organs.
(15) The common denominator appears to be the intracellular production of nitric oxide (NO), which is the activated product of organic nitrate denitration.
(16) Calculations based on the two mononitrate metabolites formed from ISDN showed an incomplete recovery of 84.1%, leading to the assumption that a simultaneous denitration to IS must have occurred.
(17) To elucidate the structure activity relationship, a comparison was made with the two denitrated derivatives: cyanoimino-3-pyridylmethylaminoethyl acetate methanesulfonate (Ki4032) and cyanoimino-3-pyridylmethylaminoethyl alcohol (Ki3315).
(18) 2-Nicotinamidoethyl alcohol, a denitrated compound of SG-75, had no vasodilator action in doses comparable to those of the parent compound.
(19) However, unchanged nicorandil and denitrated metabolite excreted into the urine represent only about 1 and 4% of the dose, respectively.
(20) Glyceryl trinitrate was denitrated by rat liver microsomes in the presence of NADPH with formation of a mixture of glyceryl dinitrates and glyceryl mononitrates.
Denitrification
Definition:
(n.) The act or process of freeing from nitrogen; also, the condition resulting from the removal of nitrogen.
Example Sentences:
(1) Hb was added to an anaerobic bacterial suspension and denitrification was initiated with either KNO2 or KNO3.
(2) A spectrophotometric method has been developed that uses extracellular hemoglobin (Hb) to trap nitric oxide (NO) released during denitrification as nitrosyl hemoglobin (HbNO).
(3) When [15]nitrite was used as substrate for the N2-forming denitrification, 15N2O, 15NO, and 14N15N were obtained as the products.
(4) Simultaneous processes of nitrification and denitrification were observed in optimal aerated manure similar to activated sludge processes.
(5) In faecal slurries, however, denitrification was a relatively minor route of NO3- dissimilation, since only about 3% of the NO3- was converted to gaseous products, with NO3- being mainly reduced to NO2- and NH4+.
(6) Conversely, energy was conserved when either nitrate, nitrite or nitrous oxide functioned as the oxidants during denitrification-dependent proton translocation experiments.
(7) A highly sensitive denitrification bioassay was developed for detection of NO3- and NO2- in rhizosphere soil samples.
(8) The kinetics of each step of denitrification was examined in resting cell suspensions.
(9) Effects of illumination on denitrification varied with electron donors.
(10) Effects of various inhibitors on denitrification were examined in light-succinate and dark-lactate systems.
(11) The regulation of nitrate respiration at the level of transport by oxygen may represent a major mechanism by which the entire denitrification pathway is regulated in P. aeruginosa.
(12) Mineralization of the labile fraction of the soil organic carbon via microbial denitrification occurred without an observed acclimation period and was rapid compared with PAH degradation.
(13) Denitrification by two of the strains was quantitatively studied using cell suspensions.
(14) Comparison of the cell growth during denitrification indicated that the dissimilatory reduction of nitrate to nitrite is an energetically favorable process in F. oxysporum; however, further reduction of nitrite to N2O might be energy-exhausting and may function as a detoxification mechanism.
(15) The yields varied with sparging rates in agreement with a quantitative model of denitrification (Betlach, M. P., and Tiedje, J.M.
(16) Effects of illumination on the denitrification of nitrite were similar to those involving nitrate.
(17) Our observations provide evidence for a denitrification pathway in vivo of NO2(-)----NO----N2O, and N,N-bond formation catalyzed by NO reductase and not by cytochrome cd1.
(18) One of the reasons for this change is the process of denitrification due to changes in the hydrogeochemical conditions in a layer.
(19) The bulk of the denitrification activity was associated with the accumulation of NO3- in the oxidized surface zone of the sediment, but a secondary denitrification zone was occasionally found in the deeper layers where oxidized patches had been introduced by the burrowing activity of the macrofauna.
(20) Reports of the simultaneous use of oxygen and denitrification by different species of bacteria have become more common over the past few years.