(1) The nitrate metabolites showed sustained plasma profiles which can be explained by a slow release of GTN with subsequent complete first-pass denitration.
(2) Esophageal responses in normal subjects with water at the two temperatures were not affected by isosorbide denitrate.
(3) These data suggest that vascular GTN metabolism in BCA is carried out by cytosolic GST isozymes which possess a preference for C-2 denitration of GTN.
(4) The rate of denitration at each nitro group in ISDN was almost twice as high as for the same position in the corresponding mononitrate.
(5) The denitrate derivatives of KRN2391 are specific K channel openers.
(6) Denitration of organic nitrates by the microsomal fraction of rat liver was NADPH dependent and followed apparent first-order kinetics.
(7) 6:1, representing a highly selective if not specific primary denitration of the 1,2-GDN molecule.
(8) In the current study, we assessed the involvement of cytochrome P-450 in the denitration of glyceryl trinitrate and the enantiomers of isoidide dinitrate.
(9) Nitroglycerin and other organic nitrate esters elicit endothelium-independent relaxation after entering vascular smooth muscle cells and undergoing denitration and formation of NO.
(10) The individual roles of the denitrated metabolites in nitrate tolerance are still unclear.
(11) The pharmacokinetics of glyceryl trinitrate are complex and only 1% of the drug administered orally can be detected in the plasma due to a pronounced arteriovenous concentration gradient, hydrolysis in the blood, and rapid denitration in the liver.
(12) Rat liver microsomes catalyze the oxidative denitration of N omega-hydroxy-L-arginine (NOHA) by NADPH and O2 with formation of citrulline and nitrogen oxides like NO and NO2-.
(13) The highest activity was obtained under anaerobic conditions and the reaction was inhibited by O2 indicating that it is a reductive denitration.
(14) Enzymatic denitration occurs not only in the liver, but also in blood and other organs.
(15) The common denominator appears to be the intracellular production of nitric oxide (NO), which is the activated product of organic nitrate denitration.
(16) Calculations based on the two mononitrate metabolites formed from ISDN showed an incomplete recovery of 84.1%, leading to the assumption that a simultaneous denitration to IS must have occurred.
(17) To elucidate the structure activity relationship, a comparison was made with the two denitrated derivatives: cyanoimino-3-pyridylmethylaminoethyl acetate methanesulfonate (Ki4032) and cyanoimino-3-pyridylmethylaminoethyl alcohol (Ki3315).
(18) 2-Nicotinamidoethyl alcohol, a denitrated compound of SG-75, had no vasodilator action in doses comparable to those of the parent compound.
(19) However, unchanged nicorandil and denitrated metabolite excreted into the urine represent only about 1 and 4% of the dose, respectively.
(20) Glyceryl trinitrate was denitrated by rat liver microsomes in the presence of NADPH with formation of a mixture of glyceryl dinitrates and glyceryl mononitrates.
Mobile
Definition:
(a.) Capable of being moved; not fixed in place or condition; movable.
(a.) Characterized by an extreme degree of fluidity; moving or flowing with great freedom; as, benzine and mercury are mobile liquids; -- opposed to viscous, viscoidal, or oily.
(a.) Easily moved in feeling, purpose, or direction; excitable; changeable; fickle.
(a.) Changing in appearance and expression under the influence of the mind; as, mobile features.
(a.) Capable of being moved, aroused, or excited; capable of spontaneous movement.
(a.) The mob; the populace.
Example Sentences:
(1) It was found that linear extrapolations of log k' versus ET(30) plots to the polarity of unmodified aqueous mobile phase gave a more reliable value of log k'w than linear regressions of log k' versus volume percent.
(2) The mobility on sodium dodecyl sulfate-polyacrylamide gel electrophoresis is anomalous since the undenatured, cross-linked proteins have the same Stokes radius as the native, uncross-linked alpha beta gamma heterotrimer.
(3) It is likely that trunk mobility is necessary to maintain integrity of SI joint and that absence of such mobility compromises SI joint structure in many paraplegics.
(4) Their particular electrophoretic mobility was retained.
(5) This mobilization procedure allowed transfer and expression of pJT1 Ag+ resistance in E. coli C600.
(6) A substance with a chromatographic mobility of Rf = 0.8 on TLC plates having an intact phosphorylcholine head group was also formed but has not yet been identified.
(7) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(8) Sequence specific binding of protein extracts from 13 different yeast species to three oligonucleotide probes and two points mutants derived from Saccharomyces cerevisiae DNA binding proteins were tested using mobility shift assays.
(9) The molecule may already in its native form have an extended conformation containing either free sulfhydryl groups or small S-S loops not affecting mobility in SDS-PAGE.
(10) Furthermore, carcinoembryonic antigen from the carcinoma tissue was found to have the same electrophoretical mobility as the UEA-I binding glycoproteins.
(11) There was immediate resolution of paresthesia following mobilization of the impinging vessel from the nerve.
(12) The last stems from trends such as declining birth rate, an increasingly mobile society, diminished importance of the nuclear family, and the diminishing attractiveness of professions involved with providing maintenance care.
(13) In order to obtain the most suitable mobile phase, we studied the influence of pH and acetonitrile content on the capacity factor (k').
(14) Here is the reality of social mobility in modern Britain.
(15) This includes cutting corporation tax to 20%, the lowest in the G20, and improving our visa arrangements with a new mobile visa service up and running in Beijing and Shanghai and a new 24-hour visa service on offer from next summer.
(16) The toxins preferentially attenuate a slow phase of KCl-evoked glutamate release which may be associated with synaptic vesicle mobilization.
(17) Heparitinase I (EC 4.2.2.8), an enzyme with specificity restricted to the heparan sulfate portion of the polysaccharide, releases fragments with the electrophoretic mobility and the structure of heparin.
(18) The transference by conjugation of protease genetic information between Proteus mirabilis strains only occurs upon mobilization by a conjugative plasmid such as RP4 (Inc P group).
(19) Lady Gaga is not the first big music star to make a new album available early to mobile customers.
(20) Moreover, it is the recombinant p70 polypeptides of slowest mobility that coelute with S6 kinase activity on anion-exchange chromatography.