(1) The nitrate metabolites showed sustained plasma profiles which can be explained by a slow release of GTN with subsequent complete first-pass denitration.
(2) Esophageal responses in normal subjects with water at the two temperatures were not affected by isosorbide denitrate.
(3) These data suggest that vascular GTN metabolism in BCA is carried out by cytosolic GST isozymes which possess a preference for C-2 denitration of GTN.
(4) The rate of denitration at each nitro group in ISDN was almost twice as high as for the same position in the corresponding mononitrate.
(5) The denitrate derivatives of KRN2391 are specific K channel openers.
(6) Denitration of organic nitrates by the microsomal fraction of rat liver was NADPH dependent and followed apparent first-order kinetics.
(7) 6:1, representing a highly selective if not specific primary denitration of the 1,2-GDN molecule.
(8) In the current study, we assessed the involvement of cytochrome P-450 in the denitration of glyceryl trinitrate and the enantiomers of isoidide dinitrate.
(9) Nitroglycerin and other organic nitrate esters elicit endothelium-independent relaxation after entering vascular smooth muscle cells and undergoing denitration and formation of NO.
(10) The individual roles of the denitrated metabolites in nitrate tolerance are still unclear.
(11) The pharmacokinetics of glyceryl trinitrate are complex and only 1% of the drug administered orally can be detected in the plasma due to a pronounced arteriovenous concentration gradient, hydrolysis in the blood, and rapid denitration in the liver.
(12) Rat liver microsomes catalyze the oxidative denitration of N omega-hydroxy-L-arginine (NOHA) by NADPH and O2 with formation of citrulline and nitrogen oxides like NO and NO2-.
(13) The highest activity was obtained under anaerobic conditions and the reaction was inhibited by O2 indicating that it is a reductive denitration.
(14) Enzymatic denitration occurs not only in the liver, but also in blood and other organs.
(15) The common denominator appears to be the intracellular production of nitric oxide (NO), which is the activated product of organic nitrate denitration.
(16) Calculations based on the two mononitrate metabolites formed from ISDN showed an incomplete recovery of 84.1%, leading to the assumption that a simultaneous denitration to IS must have occurred.
(17) To elucidate the structure activity relationship, a comparison was made with the two denitrated derivatives: cyanoimino-3-pyridylmethylaminoethyl acetate methanesulfonate (Ki4032) and cyanoimino-3-pyridylmethylaminoethyl alcohol (Ki3315).
(18) 2-Nicotinamidoethyl alcohol, a denitrated compound of SG-75, had no vasodilator action in doses comparable to those of the parent compound.
(19) However, unchanged nicorandil and denitrated metabolite excreted into the urine represent only about 1 and 4% of the dose, respectively.
(20) Glyceryl trinitrate was denitrated by rat liver microsomes in the presence of NADPH with formation of a mixture of glyceryl dinitrates and glyceryl mononitrates.
Nitrate
Definition:
(n.) A salt of nitric acid.
Example Sentences:
(1) In this study, a potassium nitrate-polycarboxylate cement was used as a liner and was found clinically to tend to preserve pulpal vitality and significantly eliminate or decrease postoperative pain.
(2) Carbopol-940 gels, being the best of those used, were studied further for the effect of its concentration and of additives (benzalkonium chloride, phenylmercuric nitrate, chlorbutol and disodium edetate), autoclaving at 121 degrees C for 30 min and irradiation with gamma rays (2.5 Mrad), on the end product.
(3) The narX gene product may be involved in sensing nitrate and phosphorylating NARL.
(4) A new long-acting nitrate, Isomak R (forte), has been shown to be an effective antianginal drug; it increases physical stress tolerance, prevents attacks of angina of effort or angina at rest, significantly decreases pulmonary arterial occlusion pressure, peripheral arterial pressure and total peripheral resistance.
(5) The calculated daily intake of NO3- is significantly increased by drinking water nitrate content.
(6) Pharmacologic modulations of ATECD by isosorbide dinitrate (ISDN) + 2-isosorbide mononitrate (2-ISMN) + 5-isosorbide mononitrate (5-ISMN) were investigated under experimental conditions reflecting either an acute nitrate effect (platelet + control ECs + drug + ADP) or a chronic effect (platelet + 5-day nitrate-treated ECs + ADP).
(7) Nitrate reductase activity in the mice fed the fibre-free diet did not markedly alter with age.
(8) Although gallium nitrate inhibited cell growth in Tf-free medium, cellular proliferation was restored by Fe-NTA.
(9) However, neither nitration with tetranitromethane of one of the nine tyrosine residues nor Nlm-ethoxyformylation of two of the four histidine residues caused any change in hemolytic activity.
(10) Most of the patients with hypotension were taking nitrates.
(11) Nitrate measures for private water sources were obtained by testing the wells individually at the existing residences.
(12) The nitrate metabolites showed sustained plasma profiles which can be explained by a slow release of GTN with subsequent complete first-pass denitration.
(13) Paracoccus (Micrococcus) denitrificans and Escherichia coli oxidizing succinate rapidly ceased to reduce nitrate when oxygen was available, and equally rapidly commenced nitrate reduction when all the oxygen had been consumed.
(14) Lanthanum nitrate used in this investigations is a valuable marker of the intercellular spaces.
(15) Orotic acid inhibited, dose-dependently DNA synthesis in hepatocytes induced by epidermal growth factor, transforming growth factor alpha, hepatocyte growth factor, acidic fibroblast growth factor, or plasma from rats exposed to various liver cell-proliferative stimuli, such as two-thirds partial hepatectomy, lead nitrate, cyproterone acetate, ethylene dibromide, or a diet deficient in choline.
(16) It is suggested that the atmosphere of Athens favours the formation of secondary direct-acting mutagens due to the oxidation and nitration of PAH by ozone and nitrogen oxides, which are more abundant in the late spring months.
(17) Among other evidence against the classical theory for the mechanism of chlorate toxicity, is the finding that not all mutants lacking nitrate reductase are clorate resistant.
(18) Since no evaluation of the relative merits of electro and chemical cautery has been reported, a prospective randomized study was conducted to assess the effectiveness of electro-cautery and cautery with silver nitrate.
(19) Total bacterial counts, nitrate-reducing bacteria and nitrite concentration were determined in fasting gastric juice before and after 4 weeks of treatment with a strong or with a mild antacid drug, a placebo preparation and the spasmolytic agent papaverine which is known to inhibit gastric evacuation.
(20) The effect of ammonia is partially reversed by nitrate.