(1) The nitrate metabolites showed sustained plasma profiles which can be explained by a slow release of GTN with subsequent complete first-pass denitration.
(2) Esophageal responses in normal subjects with water at the two temperatures were not affected by isosorbide denitrate.
(3) These data suggest that vascular GTN metabolism in BCA is carried out by cytosolic GST isozymes which possess a preference for C-2 denitration of GTN.
(4) The rate of denitration at each nitro group in ISDN was almost twice as high as for the same position in the corresponding mononitrate.
(5) The denitrate derivatives of KRN2391 are specific K channel openers.
(6) Denitration of organic nitrates by the microsomal fraction of rat liver was NADPH dependent and followed apparent first-order kinetics.
(7) 6:1, representing a highly selective if not specific primary denitration of the 1,2-GDN molecule.
(8) In the current study, we assessed the involvement of cytochrome P-450 in the denitration of glyceryl trinitrate and the enantiomers of isoidide dinitrate.
(9) Nitroglycerin and other organic nitrate esters elicit endothelium-independent relaxation after entering vascular smooth muscle cells and undergoing denitration and formation of NO.
(10) The individual roles of the denitrated metabolites in nitrate tolerance are still unclear.
(11) The pharmacokinetics of glyceryl trinitrate are complex and only 1% of the drug administered orally can be detected in the plasma due to a pronounced arteriovenous concentration gradient, hydrolysis in the blood, and rapid denitration in the liver.
(12) Rat liver microsomes catalyze the oxidative denitration of N omega-hydroxy-L-arginine (NOHA) by NADPH and O2 with formation of citrulline and nitrogen oxides like NO and NO2-.
(13) The highest activity was obtained under anaerobic conditions and the reaction was inhibited by O2 indicating that it is a reductive denitration.
(14) Enzymatic denitration occurs not only in the liver, but also in blood and other organs.
(15) The common denominator appears to be the intracellular production of nitric oxide (NO), which is the activated product of organic nitrate denitration.
(16) Calculations based on the two mononitrate metabolites formed from ISDN showed an incomplete recovery of 84.1%, leading to the assumption that a simultaneous denitration to IS must have occurred.
(17) To elucidate the structure activity relationship, a comparison was made with the two denitrated derivatives: cyanoimino-3-pyridylmethylaminoethyl acetate methanesulfonate (Ki4032) and cyanoimino-3-pyridylmethylaminoethyl alcohol (Ki3315).
(18) 2-Nicotinamidoethyl alcohol, a denitrated compound of SG-75, had no vasodilator action in doses comparable to those of the parent compound.
(19) However, unchanged nicorandil and denitrated metabolite excreted into the urine represent only about 1 and 4% of the dose, respectively.
(20) Glyceryl trinitrate was denitrated by rat liver microsomes in the presence of NADPH with formation of a mixture of glyceryl dinitrates and glyceryl mononitrates.
Nitrogen
Definition:
(n.) A colorless nonmetallic element, tasteless and odorless, comprising four fifths of the atmosphere by volume. It is chemically very inert in the free state, and as such is incapable of supporting life (hence the name azote still used by French chemists); but it forms many important compounds, as ammonia, nitric acid, the cyanides, etc, and is a constituent of all organized living tissues, animal or vegetable. Symbol N. Atomic weight 14. It was formerly regarded as a permanent noncondensible gas, but was liquefied in 1877 by Cailletet of Paris, and Pictet of Geneva.
Example Sentences:
(1) These results are discussed in relation to the possible existence of enzyme-bound intermediates of nitrogen fixation.
(2) The measurement of the intestinal metabolism of the nitrogen moiety of glutamic acid has been investigated by oral ingestion of l-[15N]glutamic acid and sampling of arterialized blood.
(3) The induction of cells with two Y chromosomes by nitrogen mustard (NM) was examined.
(4) The disappearance of the herbicide, Avadex (40% diallate), from five agricultural soils (differing in either pH, carbon content, or nitrogen content), incubated under sterile and non-sterile conditions, was followed for a period of 20 weeks.
(5) Suspensions of isolated insect flight muscle thick filaments were embedded in layers of vitreous ice and visualized in the electron microscope under liquid nitrogen conditions.
(6) Airway closure (CV), functional residual capacity (FRC) and the distribution of inspired gas (nitrogen washout delay percentage, NWOD %) and arterial oxygen tension (PaO2) was measured by standard electrodes in eight extremely obese patients before and after weight loss (mean weights 142 and 94 kg, respectively) following intestinal shunt operation.
(7) Formula fed infants retained more nitrogen and gained weight faster.
(8) Triglyceride (Trigly) in female dogs, glutamic-pyruvic transaminase (GPT) and urea nitrogen (Urea-N) in male dogs tended to increase.
(9) Nitrogen retention was curvilinear in relation to metabolic live weight (kg0.75) in both series.
(10) Corynebacterium parvum-treated mice produce large amounts of circulating nitrogen oxides and develop a severe liver injury in response to lipopolysaccharide (LPS).
(11) Eight men and eight women each performed peak oxygen intake tests on a cycle ergometer breathing ambient air and a mixture of 12% oxygen in nitrogen (equivalent to an altitude of 4400 m) in the two experiments.
(12) From this, it was suggested that a negligible amount of oestradiol was released from these compounds and that the oestradiol moiety was useful as a carrier for the nitrogen mustard moiety.
(13) The intravenous administration of ovine placental lactogen to pregnant and non-pregnant sheep produced significant acute decreases in plasma free fatty acid, glucose and amino nitrogen concentrations.
(14) In contrast, nitrogen incubation did not alter the basal levels of TBA reactants except for a small rise associated with VE deficiency.
(15) MCT TPN was found to have some disadvantages, especially with regard to nitrogen balance and plasma albumin levels.
(16) Nitrogen mustard (N2M) treatment of rabbits induced neutropenia, and, in ligated ileal loops, it inhibited fluid secretion induced by salmonella or by cholera toxin (CT).
(17) For dipeptides containing the amino terminal residues glycine, alanine and phenylalanine, abstraction of the hydrogen from the carbon adjacent to the peptide nitrogen was the major process leading to the spin-adducts.
(18) The raw data are obtained by capillary gas chromatography using a nitrogen-phosphorus detector.
(19) Total protein, RNA, DNA, nitrogen, free amino acids and water content were determined in both lymphatic organs.
(20) This is the first evidence supporting carbon-nitrogen bond formation as the initial site of interaction between the two substrate molecules.