(1) These features of the new quaternary structure, denoted Y, may therefore be representative of quaternary states that occur transiently along pathways between the normal unliganded, T, and liganded, R, hemoglobin structures.
(2) The term true mucogingival defects has been used to denote a complete absence of attached gingiva.
(3) Cross-linking of the one-to-one complex of actin and depactin with 1-ethyl-3-[3-(dimethylamino)propyl]-carbodiimide (EDC) generated two types of cross-linked products with slightly different apparent molecular weights, denoted as 60KU and 60KL.
(4) For now, given the group's perceived correlation with consumer confidence, consensus opinion continues to denote a sell [on the shares]."
(6) Art v II-A and Art v II-B were shown to be antigenically identical with the allergen we have formerly denoted Ag7.
(7) The Pasteurella haemolytica leukotoxin determinant is composed of four contiguous genes encoded on the same DNA strand and denoted lktCABD, in the order of their genetic organization.
(9) The results of treatment with LUPIDON--LUPIDON H and LUPIDON G proved to be of equal effectiveness--can be denoted as very positive because of the good or very good effects that could be observed in more than 80% of all the cases concerned.
(10) The complaint of abdominal pain requires an orderly and thorough approach because even mild or non-specific pain can denote a potentially life-threatening intra-abdominal pathology.
(11) First-set tie-break: Kyrgios* 6-5 Nadal (*denotes server): Nerves?
(12) These collective findings may signify an interesting difference in the release process in such diverse systems or denote a dissimilarity in the transport or processing of the toxin when applied into intact neurones or cells permeabilised by detergent or streptolysin.
(13) A profile showing "no concern" on all 11 factors denotes clear acceptability of the child as an implant candidate.
(14) Each allograft tissue sample was rated as to extent of pathologic changes denoting rejection and was classified accordingly.
(15) Seven morphiceptin-like peptides with the H-Tyr-Pro-Phe-Xxx-NH2 sequence, where Xxx denotes the selected amino acids (Ala, Asp, Gly, Gln, Lys, Thr and Tyr), have been synthesized.
(16) Updated at 10.26am GMT 10.21am GMT Third set: Murray* 3-6, 4-6, 3-2 Federer (*denotes server): Federer has come to the net around 35 times.
(17) While the term "isokinetics" generally denotes a type of muscular contraction which accompanies a constant rate of limb movement, periods of acceleration and deceleration exist in the context of isokinetic exercise.
(18) The presence of squamous cells in eccrine neoplasms is not well recognized, but is usually considered to denote malignant transformation.
(19) We have demonstrated in rat hepatocytes that 3H-histamine binds specifically to novel low (microM) and high (nM) affinity sites, designated "HIC" to denote their intracellular location.
(20) The other dehydratase reaction, however, is catalyzed in nature by an enzyme denoted arogenate dehydratase.
Difficult
Definition:
(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.