(v. t.) To deprive of polarity; to reduce to an unpolarized condition.
(v. t.) To free from polarization, as the negative plate of the voltaic battery.
Example Sentences:
(1) These channels may, at least in some cases, be responsible for the generation of pacemaker depolarizations, thereby regulating firing behaviour.
(2) Such an increase in antibody binding occurred simultaneously with an increase in the fluidity of surface lipid regions, as monitored by fluorescence depolarization of 1-(trimethylammoniophenyl)-6-phenyl-1,3,5-hexatriene.
(3) In experiments performed to determine whether PtdIns(4,5)P2 hydrolysis induced by TRH may have been caused by the elevation of [Ca2+]i, the following results were obtained: the effect of TRH to decrease the level of PtdIns(4,5)P2 was not reproduced by the calcium ionophore A23187 or by membrane depolarization with 50 mM K+; the calcium antagonist TMB-8 did not inhibit the TRH-induced decrease in PtdIns(4,5)P2; and, most importantly, inhibition by EGTA of the elevation of [Ca2+]i did not inhibit the TRH-induced decrease in PtdIns(4,5)P2.
(4) In K+-depolarized basilar arteries, ifenprodil competitively antagonized the response to Ca2+, and this was enhanced by pre-incubation in calcium hopantenate.
(5) For dental procedures requiring tracheal intubation, one could perhaps use non-depolarizing muscle relaxants, like pancuronium, with reversal at the end of the procedure.
(6) Propranolol, 0.85 X 10(-6) M, did not significantly depress the ouabain-enhanced rate of phase 4 depolarization but did attenuate the response to epinephrine through beta blockade.
(7) The decrease in cardiac performance observed during ventricular pacing was related to the severity of asynchrony rather than the direction of the ventricular depolarization or change in regional myocardial tension.
(8) In the absence of external chloride changing the external potassium concentration from 2.8 mM to potassium-free caused a depolarization of the membrane of about 30 mV and a small increase in membrane resistance.
(9) Detailed voltage-clamp measurements revealed that ABA-activated ion currents could be reversed by depolarizations more positive than -10 mV.
(10) The analysis suggests that the wave-peak discharge results from synchronous alternation of depolarization potentials and long periods of postsynaptic inhibition in most of the cortical elements.
(11) Using the rate coefficient values found by SCoPfit, we simulated a voltage-clamp experiment with both models running under their Na(+)-Na+ exchange mode, and we computed the transient currents generated following voltage steps in both depolarizing and hyperpolarizing directions from a basic potential of -40 mV.
(12) Stepwise depolarizations from the holding potential (-67 to -83 mV) to a potential which varied from -10 to +63 mV resulted in an exponential decline of h from its initial level to a final, non-zero level.
(13) In the whole-cell current-clamp method, the cell membrane was depolarized by endothelin and then repolarized by nicorandil.
(14) Anthopleurin-A produced two distinct responses in crayfish giant axons: depolarization and prolongation of action potentials.
(15) Diltiazem also produced a slight decrease of both the steady-state current during depolarization and the tail current after repolarization in these concentration ranges, while the hyperpolarization activated current (Ih) was not affected significantly.
(16) Furthermore, it explains rapid termination of release after depolarization, even though Ca2+ concentration may still be high.
(17) Depolarizations induced by acetyl-Arg6-septide, a NK1-receptor selective agonist, were also antagonized by spantide with a pA2 of 6.5.
(18) This response seemed to be triggered mainly by the influx of Ca2+ through L-type Ca2+ channel activated by membrane depolarization, which was caused by the ATP-induced inward current.
(19) When the concentration of Ca2+ in the medium was raised to 10 mM was the only extracellular divalent cation present, the depolarization in response to A23187 was increased to 11-8 mV.
(20) Generally, more distant neurones (500-1300 microns) were excited for variable periods of time (3-15 min), while neurones in the vicinity of the injection site (0-500 microns) showed, after a brief period of excitation time, a long-lasting (up to 30 min) decrease in excitability or silencing of discharge, probably due to a depolarizing block and disturbances in the ionic composition of the extracellular space.
Polarization
Definition:
(n.) The act of polarizing; the state of being polarized, or of having polarity.
(n.) A peculiar affection or condition of the rays of light or heat, in consequence of which they exhibit different properties in different directions.
(n.) An effect produced upon the plates of a voltaic battery, or the electrodes in an electrolytic cell, by the deposition upon them of the gases liberated by the action of the current. It is chiefly due to the hydrogen, and results in an increase of the resistance, and the setting up of an opposing electro-motive force, both of which tend materially to weaken the current of the battery, or that passing through the cell.
Example Sentences:
(1) Using monoclonal antibodies directed against the plasma membrane of Madin-Darby canine kidney (MDCK) cells, we demonstrated previously that a glycoprotein with an Mr = 23,000 (gp23) had a non-polarized cell surface distribution and was observed on both the apical and basolateral membranes (Ojakian, G. K., Romain, R. E., and Herz, R. E. (1987) Am.
(2) It was found that linear extrapolations of log k' versus ET(30) plots to the polarity of unmodified aqueous mobile phase gave a more reliable value of log k'w than linear regressions of log k' versus volume percent.
(3) The dependence of fluorescence polarization of stained nerve fibres on the angle between the fibre axis and electrical vector of exciting light (azimuth characteristics) has been considered.
(4) A triphasic pattern was evident for the neck moments including a small phase which represented a seating of the headform on the nodding blocks of the uppermost ATD neck segment, and two larger phases of opposite polarity which represented the motion of the head relative to the trunk during the first 350 ms after impact.
(5) The remainder of the radioactivity appeared chromatographically just prior to the bisantrene peak, indicating that compounds more polar than the parent were present as transformation products.
(6) In the triploids, the 40 female chromosomes present (mouse, n = 20) were derived from a single diploid pronucleus formed after the extrusion of a first polar body, and following the monospermic fertilization of primary oocytes.
(7) Genetic regulation of the ilvGMEDA cluster involves attenuation, internal promoters, internal Rho-dependent termination sites, a site of polarity in the ilvG pseudogene of the wild-type organism, and autoregulation by the ilvA gene product, the biosynthetic L-threonine deaminase.
(8) These transcriptional experiments provide in vitro confirmation for the latent rho-dependent termination site model of transcriptional polarity.
(9) I evaluated use of the fluorescence polarization technique to measure neocarzinostatin, a proteinaceous antitumor antibiotic, and its antibody, in serum.
(10) During photoirradiation, both in vivo and in vitro, the serum polar (ZE)-bilirubin IX alpha concentration increased remarkably, but unbound-bilirubin values were not affected at all.
(11) Actin is present in chromosomal spindle fibres, with consistent polarity.
(12) The results are summarized in Table I, indicating that the ratio of formation of the cis product (2) increases as a solvent becomes more polar.
(13) No disorganization of the muscle structure was detected by polarized light and electron microscopic inspection.
(14) Subsequently, due to the rotation of the original polar axis in one hemisphere, the third cleavage plane through one half of the egg is transverse to the third cleavage plane through the other half.
(15) These activities define both the polarity of the anterior-posterior (AP) axis and the spatial domains of expression of the zygotic gap genes, which in turn control the subsequent steps in segmentation.
(16) It is released into the urine in large quantities and thus represents a potential candidate for a protein secreted in a polarized fashion from the apical plasma membrane of epithelial cells in vivo.
(17) The anodic polarization profiles are presented, as well as scanning electron micrographs and x-ray analysis of the corroded amalgam surfaces.
(18) Descending neurons have opposite structural polarity, arising in the brain and terminating in segmental regions of the fused ventral ganglia.
(19) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(20) Halothane variably increased the current produced (and therefore the estimated oxygen tension) at all polarizing voltages in saline solution equilibrated with either N2 or air.