(n.) The state of desponding; loss of hope and cessation of effort; discouragement; depression or dejection of the mind.
Example Sentences:
(1) After she hit the two-year mark, five-month mark, she’s been despondent.
(2) It was hard to reconcile Pistorius's despondent figure in black suit and tie and white shirt with the "blade runner" who thrilled stadiums around the world and became the first amputee to run in the Olympics .
(3) But actually what we felt as the days and weeks passed – me and Kelly and my father – was a sense of despondency, of being let down, of just sinking through the system.
(4) In 46%, the subject had expressed despondency over illness.
(5) There is a sense of despondency spreading in Pakistan.
(6) The value of Brazil's currency, the real, has ballooned since President Lula took power, leaving exporters despondent and leading Goldman Sachs to classify it as the most overvalued currency on earth.
(7) , became a battle manual for despondent Democrats after George W Bush’s second election victory.
(8) He told worshippers at Durham cathedral: "It is very easy to be despondent about the church.
(9) Pablo Simón, a political science professor at Madrid’s Carlos III University, argues that a fresh election and the attendant politicking could further alienate an already despondent electorate.
(10) In Spike Jonze 's Her, set in a near future LA, Phoenix is Theodore, a despondent, solitary writer whose life picks up when he falls in love with Samantha, a portable, artificially intelligent operating system who provides more than he could have hoped for.
(11) [It is] all the Ds: despair, depression, despondency.” “Chinese media are under a lot of pressure right now.
(12) Jose Mourinho: Rafa Benitez destroyed my work at Inter within six months Read more There wasn’t too much to get excited or despondent about in any of the displays in New York, Charlotte or here in Washington DC.
(13) Rob came very close to death many times, and I think part of James's despondency now comes from having saved Rob so many times, only to lose him in the end.
(14) They have been left despondent by Francis's occasional comments on the issue, in which he has generally defended the church while condemning the abuse.
(15) Despondent MPs tonight voiced fears that Britain may experience a milder version of the "clean hands" affair that brought down Italy's postwar political settlement in the 1990s.
(16) Strong was despondent over Bilibid but recovered and developed a noteworthy career in American tropical medicine.
(17) It has been demonstrated that a small proportion of women taking oral contraceptives develop a depressive syndrome characterized by despondency, tension, and changes in sex desire.
(18) A classic portrait of the grieving widower, his despondency did not surprise mental health professionals.
(19) For those who don't get the results they hoped for – and their chosen universities – the moments after the envelope are full of dread and despondency.
(20) It is easy to see why players bounce off Klopp and indeed it was tempting to wonder if Chelsea’s despondent players were casting the occasional envious glance at the German, whose energetic and engrossing touchline demeanour offered a welcome shade of light next to José Mourinho ’s dark scowl.
Loss
Definition:
(v. t.) The act of losing; failure; destruction; privation; as, the loss of property; loss of money by gaming; loss of health or reputation.
(v. t.) The state of losing or having lost; the privation, defect, misfortune, harm, etc., which ensues from losing.
(v. t.) That which is lost or from which one has parted; waste; -- opposed to gain or increase; as, the loss of liquor by leakage was considerable.
(v. t.) The state of being lost or destroyed; especially, the wreck or foundering of a ship or other vessel.
(v. t.) Failure to gain or win; as, loss of a race or battle.
(v. t.) Failure to use advantageously; as, loss of time.
(v. t.) Killed, wounded, and captured persons, or captured property.
(v. t.) Destruction or diminution of value, if brought about in a manner provided for in the insurance contract (as destruction by fire or wreck, damage by water or smoke), or the death or injury of an insured person; also, the sum paid or payable therefor; as, the losses of the company this year amount to a million of dollars.
Example Sentences:
(1) Tryptic digestion of the membranes caused complete disappearance of the binding activity, but heat-treatment for 5 min at 70 degrees C caused only 40% loss of activity.
(2) These studies, in addition to demonstrating that the placenta contains TRH deamidase activity, suggest that losses of fetal TRH through the placenta are not large.
(3) Our results indicate that increasing the delay for more than 8 days following irradiation and TCD syngeneic BMT leads to a rapid loss of the ability to achieve alloengraftment by non-TCD allogeneic bone marrow.
(4) Even with hepatic lipase, phospholipid hydrolysis could not deplete VLDL and IDL of sufficient phospholipid molecules to account for the loss of surface phospholipid that accompanies triacylglycerol hydrolysis and decreasing core volume as LDL is formed (or for conversion of HDL2 to HDL3).
(5) Histological studies of nerves 2 years following irradiation demonstrated loss of axons and myelin, with a corresponding increase in endoneurial, perineurial, and epineurial connective tissue.
(6) The stages of mourning involve cognitive learning of the reality of the loss; behaviours associated with mourning, such as searching, embody unlearning by extinction; finally, physiological concomitants of grief may influence unlearning by direct effects on neurotransmitters or neurohormones, such as cortisol, ACTH, or norepinephrine.
(7) Moreover, in DCVC-treated cells the mitochondria could not be stained with rhodamine-123, indicating severe mitochondrial damage and loss of membrane potential.
(8) Adenosine diphosphate (ADP) afforded significant protection only at the very highest concentration (5.0 mM); inorganic pyrophosphate (PPi) did not protect against loss of latency at any concentration.
(9) The west Africa Ebola epidemic “Few global events match epidemics and pandemics in potential to disrupt human security and inflict loss of life and economic and social damage,” he said.
(10) Thus, it appears that neuronal loss may account for up to roughly half of the striatal D2 receptor loss during aging.
(11) Hearing loss at 8 kHz would shorten the I-V interval, while a loss at 4 kHz would be expected to lengthen the interval.
(12) It is concluded the decrease in cellular volume associated with substitution of serosal gluconate for Cl results in a loss of highly specific Ba2+-sensitive K+ conductance channels from the basolateral plasma membrane.
(13) With prolonged ischemia, it is only transient and is followed by a gradual loss of the adenylyl cyclase activity.
(14) A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness.
(15) Periodontal disease activity is defined clinically by progressive loss of probing attachment and radiographically by progressive loss of alveolar bone.
(16) But not only did it post a larger loss than expected, Amazon also projected 7% to 18% revenue growth over the busiest shopping period of the year, a far cry from the 20%-plus pace that had convinced investors to overlook its persistent lack of profit in the past.
(17) The findings confirm and quantitate the severe atrophy of the neostriatum, in addition to demonstrating a severe loss of cerebral cortex and subcortical white matter in HD.
(18) We could do with similar action to cut out botnets and spam, but there aren't any big-money lobbyists coming to Mandelson pleading loss of business through those.
(19) The triad of epigastric pain unrelieved by antacids, bilious vomiting, and weight loss, particularly after a gastric operation should make one suspect this syndrome.
(20) The temporary loss of a family member through deployment brings unique stresses to a family in three different stages: predeployment, survival, and reunion.