(a.) Marked by despondence; given to despondence; low-spirited; as, a despondent manner; a despondent prisoner.
Example Sentences:
(1) After she hit the two-year mark, five-month mark, she’s been despondent.
(2) It was hard to reconcile Pistorius's despondent figure in black suit and tie and white shirt with the "blade runner" who thrilled stadiums around the world and became the first amputee to run in the Olympics .
(3) But actually what we felt as the days and weeks passed – me and Kelly and my father – was a sense of despondency, of being let down, of just sinking through the system.
(4) In 46%, the subject had expressed despondency over illness.
(5) There is a sense of despondency spreading in Pakistan.
(6) The value of Brazil's currency, the real, has ballooned since President Lula took power, leaving exporters despondent and leading Goldman Sachs to classify it as the most overvalued currency on earth.
(7) , became a battle manual for despondent Democrats after George W Bush’s second election victory.
(8) He told worshippers at Durham cathedral: "It is very easy to be despondent about the church.
(9) Pablo Simón, a political science professor at Madrid’s Carlos III University, argues that a fresh election and the attendant politicking could further alienate an already despondent electorate.
(10) In Spike Jonze 's Her, set in a near future LA, Phoenix is Theodore, a despondent, solitary writer whose life picks up when he falls in love with Samantha, a portable, artificially intelligent operating system who provides more than he could have hoped for.
(11) [It is] all the Ds: despair, depression, despondency.” “Chinese media are under a lot of pressure right now.
(12) Jose Mourinho: Rafa Benitez destroyed my work at Inter within six months Read more There wasn’t too much to get excited or despondent about in any of the displays in New York, Charlotte or here in Washington DC.
(13) Rob came very close to death many times, and I think part of James's despondency now comes from having saved Rob so many times, only to lose him in the end.
(14) They have been left despondent by Francis's occasional comments on the issue, in which he has generally defended the church while condemning the abuse.
(15) Despondent MPs tonight voiced fears that Britain may experience a milder version of the "clean hands" affair that brought down Italy's postwar political settlement in the 1990s.
(16) Strong was despondent over Bilibid but recovered and developed a noteworthy career in American tropical medicine.
(17) It has been demonstrated that a small proportion of women taking oral contraceptives develop a depressive syndrome characterized by despondency, tension, and changes in sex desire.
(18) A classic portrait of the grieving widower, his despondency did not surprise mental health professionals.
(19) For those who don't get the results they hoped for – and their chosen universities – the moments after the envelope are full of dread and despondency.
(20) It is easy to see why players bounce off Klopp and indeed it was tempting to wonder if Chelsea’s despondent players were casting the occasional envious glance at the German, whose energetic and engrossing touchline demeanour offered a welcome shade of light next to José Mourinho ’s dark scowl.
Melancholic
Definition:
(a.) Given to melancholy; depressed; melancholy; dejected; unhappy.
(n.) One affected with a gloomy state of mind.
(n.) A gloomy state of mind; melancholy.
Example Sentences:
(1) The authors took multiple serum samples for measurement of melatonin between 4:30 p.m. and 7:30 a.m. in seven male depressed patients with melancholia and five healthy male control subjects and found that melancholic patients had a significantly lower rise of melatonin.
(2) With the Extracted Criteria, initial insomnia, early waking, anorexia, weight loss, loss of libido, and worsened mood in the morning were all significantly more common in melancholia than in non-melancholic depression, while increased appetite was more common in non-melancholia.
(3) Patients with a past history of major melancholic depression or severe agoraphobia had similar binding parameters as panic disorder patients without a history of depression or severe agoraphobia.
(4) Every episode was diagnosed cross-sectionally as schizophrenic, melancholic, manic, manic-depressive mixed, schizodepressive, schizomanic or schizomanic-depressive mixed.
(5) Lower fT3 levels were also observed in melancholic depressed patients when compared with nonmelancholic depressed patients or when compared with normal control subjects.
(6) Melancholic episode: according to "Major Depression, Melancholic Type" of DSM-III-R. Manic episode: according to the criteria of DSM-III, slightly modified.
(7) Controlling for baseline biological, clinical, and demographic factors eliminated the higher prolactin response in the melancholic and psychotic patients, attenuated the blunted GH response in the unipolar patients, and revealed a blunted GH response in the melancholic patients.
(8) Occasionally certain behavioural styles and symptoms can be seen in melancholics which are difficult to classify as hysterical or pseudohysterical.
(9) However, when subjects were stratified based upon the presence or absence of DSM III-R melancholic features, the melancholic depressives showed little change in weekly depression ratings compared to patients without melancholic symptoms (p less than 0.001).
(10) Sixty-four percent of buspirone patients and 50% of placebo patients were melancholic; 64% of buspirone patients and 74% of placebo patients discontinued treatment before the end of the study.
(11) To explore whether abnormal CCK secretion during feeding may be related to pathophysiological mechanisms in disorders associated with appetite abnormalities, we report here studies of the plasma CCK response to a test meal in patients with bulimia nervosa, as well as seasonal (hyperphagic) and melancholic (anorexic) depression.
(12) A tendency in the opposite direction of the thyroxine values was found in bipolar (melancholic) patients.
(13) The results suggest that the 'depressive attributional style' may be specific to melancholic patients, and underline the importance of studying well-defined diagnostic subgroups.
(14) The test may have power in differentiating severe melancholic depression, mania, or acute psychosis from chronic psychosis (87% specificity) or dysthymia (77% specificity).
(15) In addition, when patients with more severe, melancholic, subtype of depression were examined, adinazolam was also as effective as imipramine.
(16) In the depressed group, irritability and DSM-III-R melancholic type predicted 40% or the variance of stage 4 increment after ritanserin, as assessed by stepwise multiple regression.
(17) In conditions of conflict between probability and value of reinforcement the dogs manifested two opposite strategies of behaviour: orientation to highly probable events (choleric and phlegmatic) and to low-probable events (sanguinic and melancholic) what is connected with individual properties of functioning and the character of interaction of four brain structures (frontal cortex, hippocampus, hypothalamus, amygdala).
(18) The sensitivity of the DST (rate of a positive outcome, or nonsuppression of cortisol) in major depression is modest (about 40%-50%) but is higher (about 60%-70%) in very severe, especially psychotic, affective disorders, including major depression with psychotic as well as melancholic features, mania, and schizoaffective disorder.
(19) Serotonin in platelet-free plasma and in platelets from melancholics was significantly reduced to 30% and 60% of their respective control values.
(20) Many wept, wiping tears off their faces as the melancholic tunes of the hymns reached them through loudspeakers.