(n.) Purpose for which anything is destined; predetermined end, object, or use; ultimate design.
(n.) The place set for the end of a journey, or to which something is sent; place or point aimed at.
Example Sentences:
(1) They are going to all destinations.” Supplies are running thin and aftershocks have strained nerves in the city.
(2) The amino-terminal region of a 70 kDa mitochondrial outer membrane protein of yeast and the presequence of cytochrome c1, an inner membrane protein exposed to the intermembrane space, are thought to be responsible for localizing the proteins in their final destinations after synthesis in the cytosol.
(3) Although the reeler, an autosomal recessive mutant mouse with the abnormality of lamination in the central nervous system, died about 3 weeks of age when fed ordinary laboratory chow, this mouse could grow up normally and prolong its destined, short lifespan to 50 weeks and more when given assistance in taking paste food and water from the weaning period.
(4) In Europe, for example, the basket of goods tested has fallen 18% in Greece (Corfu) to £57.50, making prices a third cheaper than Italy (Sorrento) at £87.06, the most expensive of six eurozone destinations surveyed.
(5) Obasanjo was in the UK to promote investment in Nigeria, sub-Saharan Africa's most populous country and its second biggest economy, not to mention one of the world's most promising emerging destinations for international investors.
(6) During 70 days or so from the time of recruitment until just before the beginning of the cycle during which a follicle is destined to ovulate, folliculogenesis is a continuous process dependent on gonadotrophins but independent of the fluctuations in their concentrations occurring during this time.
(7) Co-founder Cyndi Anafo’s mother used to run a Ghanaian grocery in the covered market that has recently been rebranded Brixton Village, a target destination for food tourists and wealthy Londoners.
(8) With grievous amazement, never self-pitying but sometimes bordering on a sort of numbed wonderment, Levi records the day-to-day personal and social history of the camp, noting not only the fine gradations of his own descent, but the capacity of some prisoners to cut a deal and strike a bargain, while others, destined by their age or character for the gas ovens, follow "the slope down to the bottom, like streams that run down to the sea".
(9) The U.S. Department of Energy has so far approved six applications for natural gas export terminals, but most of that gas is destined for Asia, where prices are far higher and companies can make more money than selling it in Europe.
(10) It is clear that different subsets of navigational cues guide sensory afferents to muscle and to cutaneous destinations.
(11) KSmythe Make a splash in the cold: Bergen, Norway Facebook Twitter Pinterest Photograph: Getty Images Bergen, even when the fjords are too wet and dreary to visit, is still a relaxing destination for a winter break in Norway.
(12) Because of these problems, the decision to be tested, regardless of the destination, requires that "testees" be fully informed and consent to testing.
(13) The snake with the longest journey took nine months to reach its destination.
(14) While mindful of the security situation in north Africa, he saw the fears over some other destinations as an opportunity for a less crowded break.
(15) The biosynthesis of 5-ALA, destined for phycobilins, occurs via the five-carbon pathway, now well established for tetrapyrrole synthesis in plants and distinct from the mammalian pathway.
(16) Earlier this month, Israeli warplanes struck targets near the capital, Damascus, reportedly wiping out Iranian missiles destined for Hezbollah.
(17) It is emphasized that by varying these parameters we can influence not only the rate of blood elimination but also the intrahepatic destination of the liposomes.
(18) Michael Yoshikami, the founder of Destination Wealth Management, said Citigroup had a long way to go.
(19) After 32 years in power Yemen's president, Ali Abdullah Saleh, looks destined to become the next Arab leader to be toppled as 11 military commanders, including a senior general, defected from the regime, promising to protect anti-government protesters in the capital.
(20) Follicles collected from cows destined to enter relatively normal or short luteal phases if induced to ovulate were compared for numbers of receptors for luteinizing hormone (LH) in granulosal and thecal cells and for follicle-stimulating hormone (FSH) in granulosal cells.
Terminus
Definition:
(n.) Literally, a boundary; a border; a limit.
(n.) The Roman divinity who presided over boundaries, whose statue was properly a short pillar terminating in the bust of a man, woman, satyr, or the like, but often merely a post or stone stuck in the ground on a boundary line.
(n.) Hence, any post or stone marking a boundary; a term. See Term, 8.
(n.) Either end of a railroad line; also, the station house, or the town or city, at that place.
Example Sentences:
(1) Conditions for limited digestion of the heterodimer by subtilisin, removing only the carboxyl terminus, were determined.
(2) The elongation of helix III with the addition of helix II at the N-terminus somewhat stabilizes the ordered structure.
(3) Synthetic DNA corresponding to the hydrophobic domain of cytochrome b5 was enzymatically fused in-frame to cloned DNA corresponding to the C-terminus of the Escherichia coli enzyme, beta-galactosidase.
(4) TCR beta chain gene expression of individual T cell clones that share the same MHC class II restriction and similar fine specificity for the encephalitogenic NH2 terminus of the autoantigen myelin basic protein (MBP) has been examined.
(5) When these sequences were fused to the N terminus of yeast cytochrome oxidase subunit IV lacking its own presequence, they directed the attached subunit IV to its correct intramitochondrial location in vivo.
(6) Both proteins appeared to be recognized by antibodies against the amino (N) terminus of the alpha 1 subunit sequence.
(7) These plasmin-cleaved peptides are derived from the COOH terminus of C2b, and they induce the contraction of estrous rat uterus.
(8) From the decreased alignment at the N-terminus and the presence of additional residues compared with bacterial phosphorylases, we conclude that the regulatory sequences that also carry the phosphorylation site in the muscle enzyme were joined to a presumed ancestral precursor gene by gene fusion after separation of the eukaryotic and prokaryotic lines of descent.
(9) Microsequencing of the peptides resolved by sodium dodecyl sulfate-polyacrylamide gel electrophoresis indicates that the amino terminus of the protein is disposed at or near the cytoplasmic surface of the gap junction, and that this surface also contains a protease-hypersensitive hydrophilic sequence between residues 109 and 123, presumably connecting the second and third transmembrane segments.
(10) The N-terminal sequence (15 amino acid residues) of the L-proline activating fragment obtained by trypsin treatment was identical with that of GS2, indicating that the L-proline activating site is located at the N-terminus of the native synthetase.
(11) It is suggested that a general manner of folding may be a common feature of the heterogeneous population of kappa-chains: one bridge which folds an invariable stretch of the chain, another bridge which folds a stretch that varies from protein to protein, and a bridge at the C-terminus which is the interchain link.
(12) Cysteine proteinase I cleaved peptides primarily from the C-terminal region of Tg, which contained two major hormonogenic sites, while cathepsin-B produced peptides mainly from the N-terminus, containing another major hormonogenic site.
(13) Deletions from the N terminus of LMM did not alter the solubility properties of the expressed material, but deletion of 92 residues from the C terminus caused a large increase in solubility at low ionic strength, indicating that a determinant important for interaction between LMM molecules was located in this region.
(14) Middle component particles of bean pod mottle virus (BPMV) containing small protein subunits with a cleaved C terminus were used to produce monoclonal antibodies (MAbs).
(15) We find that the NH2-terminus of PTH is rapidly degraded in situ by the liver but that both liver and especially kidney nevertheless contain low levels of NH2-terminal PTH fragments that, although not released into the blood, are large enough to be potentially active.
(16) 2) By contrast, the COOH terminus is an inhibitory regulator of mitogenesis, and removal of the terminal 43 amino acids converts the receptor from a moderately active growth signaler to a very active one.
(17) Since the HPV-16 E6-promoted degradation involves the ubiquitin-dependent proteolysis pathway, specific mutations were made in the amino terminus of p53 to examine whether the E6 targeted degradation involved the N-end rule pathway.
(18) Examination of the inhibitory effect of ATP using oligo(dA)12-18 as well as activated DNA as primers revealed that (a) ATP inhibition is not due to its addition onto a 3'-OH primer terminus ad judged by the lack of incorporation of labeled ATP, although under similar conditions incorporation of GTP can be demonstrated, (b) a consistent degree of inhibition was noted independent of primer or enzyme concentration; (c) addition of ATP to an ongoing reaction promptly reduces the rate of polymerization; (d) kinetic studies indicate a competitive (with respect to substrate deoxy triphosphate) pattern of inhibition; (e) addition of excess deoxyribotriphosphate promptly relieves the inhibition.
(19) A peptide corresponding to the COOH terminus (residues 45-65) was synthesized utilizing lysine 47 as a specific residue to conjugate to thyroglobulin as a carrier for raising antibodies in mice.
(20) Myristic acid-labeled virions contained a single radioactive protein, p10, supporting the mapping of this molecule to the amino terminus.