(n.) The process of growing worse, or the state of having grown worse.
Example Sentences:
(1) It is followed by rapid neurobehavioral deterioration in late infancy or early childhood, a developmental arrest, plateauing, and then either a course of retarded development or continued deterioration.
(2) Hypertensive disorders in pregnancy are frequently accompanied by deteriorated renal functions and by pathological lesions in the glomeruli.
(3) A remarkable deterioration of prognosis with increasing age rises the question whether treatment with cytotoxic drugs should be tried in patients more than 60 years old.
(4) "There is … a risk that the political, trade, and gas frictions with Russia could lead to strong deterioration in economic relations between the two countries, with a significant drop in Ukraine's exports to and imports from Russia.
(5) This suggests that there was a deterioration of the vasoconstrictor response and indicated a possible effect of heat at the receptor or effector level.
(6) Four patients had previously been diverted and the other six were reconstructed because of intractable incontinence or deteriorating renal function.
(7) Finally, these cases support the existence of a therapeutic upper limit for desipramine plasma concentrations, above which clinical deterioration occurs.
(8) In view of the high mortality every clinical deterioration of patients with cirrhosis should alert the physician of the presence of SBP.
(9) The authors present a boy with a sudden onset a large intracranial hematoma causing rapid neurologic deterioration.
(10) The data suggest late hemodynamic deterioration after 48 hours of IABC.
(11) Aspartylglycosaminuria (AGU) is a hereditary metabolic disorder characterized by slowly progressive mental deterioration from infancy, urinary excretion of large amounts of aspartylglycosamine, and decreased activity of the lysosomal enzyme aspartylglcosamine amido hydrolase in various body tissues and fluids.
(12) The dilemma focuses on whether the obliteration or removal of the cystic areas will benefit or cause further deterioration of the patient's condition.
(13) Bacteriuria was not associated with deteriorating renal function determined by serial plasma creatinine estimations.
(14) The deteriorating situation would worsen if ministers pressed ahead with another controversial Lansley policy – that of abolishing the cap on the amount of income semi-independent foundation trust hospitals can make by treating private patients.
(15) During a postoperative follow-up period of 1 to 3 years, no further deterioration has been observed and magnetic resonance studies have demonstrated a space filled with cerebrospinal fluid (CSF) around the lumbosacral cord.
(16) Use of sunglasses that block all ultraviolet radiation and severely attenuate high-energy visible radiation will slow the pace of ocular deterioration and delay the onset of age-related disease, thereby reducing its prevalence.
(17) Sechin warned the west earlier this week that expanding sanctions over Russia's annexation of Ukraine's Crimea region would only make the political situation deteriorate further, according to Reuters.
(18) Rates of clinical deterioration and frequencies of attacks were not significantly different between treated and control groups.
(19) In a follow-up of 17 HIV-positive subjects, nine presented deteriorated reflexes in the tests and higher IgG immune complex levels.
(20) However, these good results deteriorated on longer follow-up and were not expected to be permanent.
Senile
Definition:
(a.) Of or pertaining to old age; proceeding from, or characteristic of, old age; affected with the infirmities of old age; as, senile weakness.
Example Sentences:
(1) Hyperopia was more common in younger persons, but senile cataract, macular degeneration and palpebral dermatochalasis or blepharochalasis were more common in older persons.
(2) Mucosal drying medications and senile salivary gland atrophy seemed to contribute to the high frequency of sicca in this population with a lesser proportion of the subjects demonstrating previously undiagnosed Sjögren's and possible Sjögren's syndrome.
(3) Key findings include a progressive degeneration of these cholinergic neurons characterized by the formation of immunoreactively atypical NFT, the loss of intraneuronal lipofuscin, a lack of senile plaque and beta-amyloid deposition within the basal forebrain, and end-stage gliosis without residual extracellular NFT.
(4) This finding is consistent with the hypothesis that the majority of deaths attributed to presenile dementia and the majority of deaths from senile dementia are the result of the same disease entity.
(5) Diagnoses like neuroses, alcoholism, and senile dementia produced many visits by few patients.
(6) Her mother had only senile pigmented modification of the fundus and her three daughters had mild macular pigmented changes, like "salt and pepper."
(7) The reduced effectiveness of protection by antibody against viruses which had caused influenza disease 20--30 years ago was conducive to the spread of influenza Al cases among middle-aged and senile population.
(8) Since the detailed molecular events leading to the formation of amyloid-containing senile plaques of the Alzheimer's disease (AD) brain are incompletely understood, the present studies were undertaken to address this issue using a combination of molecular and cytochemical approaches.
(9) Recently in senile dementia of Alzheimer type, neuronal loss of cholinergic neurons in the substantia innominata is described.
(10) Whereas markedly high values of 1, 25-(OH)2D in plasma were found in some cases of primary hyperparathyroidism with prominent bone resorption, relatively low values were seen in some patients with chronic renal failure, senile osteoporosis, osteomalacia and hypercalcemia due to bone metastasis.
(11) The ultrastructure of the water-clear cells of the parathyroid glands in the starved adult and senile animals almost resembled that of the control adult and senile animals.
(12) The study of the drugs effective in the treatment of cognitive deficits and memory loss associated with senile dementia of the Alzheimer's type--tacrine and amiridin, acetylcholinesterase inhibitor physostigmine and nootrop piracetam on uptake of 3H-serotonin (3H-5-HT), 3H-adrenaline (3H-AD), 3H-noradrenaline (3H-HA), 2H-dopamine (3H-DA), 3H-gamma-aminobutyric acid (3H-GABA), 3H-glutamic acid (3H-GLU), 3H-aspartic acid (3H-ASP) and 3H-glycine (3H-GLI) showed that tacrine and amiridin (5 x 10(-5) M) statistically significantly (P less than 0.05) inhibited the uptake of 3H-DA and 3H-5-HT.
(13) The results are as follows: The neurites of senile DRG cells appeared 7 days later than the neurites of neonatal DRG cells.
(14) Although a trend was observed for TMA-DPH mobility to parallel histopathologic severity in hippocampal specimens, the biophysical changes did not appear to reflect a loss of neuronal membranes relative to glial membranes or the presence of senile plaques or neurofibrillary tangles.
(15) Corticotropin-releasing hormone-immunoreactivity (CRH-IR) and CRH receptors (binding capacity and affinity) were measured in postmortem cortical areas from depressed subjects, two groups of senile dementia of the Alzheimer type (SDAT), and age-, sex-, and postmortem-delay-matched controls.
(16) Anti-beta-peptide stained cerebrovascular and plaque core amyloid in all AD cases as well as cerebrovascular amyloid and senile plaque core amyloid in five elderly CJD cases.
(17) Senile dementia and admission other than from the patient's own home, were factors associated with a poorer long term outcome.
(18) In this study 40 fragments of human skin from 4 groups were included: children, adults, aged people with lesions of senile keratosis and without lesions of senile keratosis.
(19) To examine the efficacy of cholinergic enhancement in senile dementia of the Alzheimer type (SDAT), oral physostigmine was given to eight patients in a cross-over trial of three dose levels and a matching placebo.
(20) Here the presence and distribution within senile plaques of various epitopes of the beta-amyloid precursor protein (APP) are compared with the distribution of A beta P itself and markers for plaque neurites.