(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.
Harmful
Definition:
(a.) Full of harm; injurious; hurtful; mischievous.
Example Sentences:
(1) Chapman and the other "illegals" – sleeper agents without diplomatic cover – seem to have done little to harm American national security.
(2) Bacterial lipopolysaccharides (LPS), which are important components of the cell wall of gram-negative bacteria, induce a number of host responses both beneficial and harmful.
(3) Robert Francis QC's official report in February on the Mid Staffordshire care scandal, in which an estimated 400 to 1,200 patients died unnecessarily at Stafford hospital between 2005 and 2008, called for the NHS to make "zero harm" its objective.
(4) I realise now that the drug is far less harmful then I believed at the time.
(5) Irrespective of method, the suicide attempt was predominantly a psychotic act of young single people with chronic, severe disorders and considerable past parasuicide, in a setting of escalating self-harm.
(6) Speaking to reporters at the Pentagon, People's Liberation Army's chief of the general staff Gen Fang Fenghui also warned that the US must be objective about tensions between China and Vietnam or risk harming relations between Washington and Beijing.
(7) Jails and prison populations are unique in the incidence of deliberate self-harm, but the phenomenon is not well understood.
(8) It’s been widely reported that black people are disproportionately harmed by the mortgage market.
(9) Repeat patients were more likely to threaten to harm others, have a diagnosis of adjustment disorder, conduct or oppositional disorder and be under the care of a child welfare agency.
(10) Considerations of different ways of obtaining informed consent, determining ways of minimizing harm, and justifications for violating the therapeutic obligation are discussed but found unsatisfactory in many respects.
(11) Judge John Burgess told the men that their intention was “to do great harm in a peaceful community”.
(12) Lack of transparency about the nature of the relationship between police and media also led to speculation and perceptions, whatever the facts, that caused "serious harm".
(13) The problem of the achondroplast arises when his surroundings, right from the start, reject his disorder, connoting it with destructive anxiety: this seriously harms the subject's physical image, making him an outcast.
(14) Religious efforts to address the issue have also been complicit in absolving men of their crimes, objectifying women and doing more harm than good with campaigns that blame women for the phenomenon.
(15) Both the observance of occupational limit-values for dusts and other harmful materials at the work place, which have effects on the respiration system, and the medical survey of workers with the use of special methods for examination of respiratory system are necessary.
(16) Changes in the fitness of harmful mutations may therefore impose a greater long-term disadvantage on asexual populations than those which are sexual.
(17) The possibility of being liable if an incompetent student becomes registered and causes harm is also discussed.
(18) Butler was convicted of grevious bodily harm and child cruelty, and sentenced to prison.
(19) Was the Dalkon Shield so harmful in the nulliparous woman?
(20) Education can increase compliance and sometimes modify harmful behavior.