(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.
Hazardous
Definition:
(a.) Exposed to hazard; dangerous; risky.
Example Sentences:
(1) The purpose of this paper is to discuss the potential for integrating surveillance techniques in reproductive epidemiology with geographic information system technology in order to identify populations at risk around hazardous waste sites.
(2) They more precisely delineate the hazard identification process and the factors important in supporting risk decisions for developmental toxicants than does any other document.
(3) These findings suggest that aerosolization of ATP into the cystic fibrosis-affected bronchial tree might be hazardous in terms of enhancement of parenchymal damage, which would result from neutrophil elastase release, and in terms of impaired respiratory lung function.
(4) Therefore, a mortality analysis of overall survival time alone may conceal important differences between the forces of mortality (hazard functions) associated with distinct states of active disease, for example pre-remission state and first relapse.
(5) If there was to be guerrilla warfare, I wanted to be able to stand and fight with my people and to share the hazards of war with them.
(6) The time to recovery of full consciousness, time to parasite clearance, and mortality were examined with Cox proportional-hazards regression analysis.
(7) Classification into hazard categories depends on the overall strength of evidence that an agent may cause mutations in humans.
(8) Results in this preliminary study demonstrate the need to evaluate the hazard of microbial aerosols generated by sewage treatment plants similar to the one studied.
(9) As for workers potentially exposed to selected chemical hazards, the first survey provides no consistent evidence that such workers were more likely to receive exposure-specific tests than other workers.
(10) Ecological risk assessments are used by the US Environmental Protection Agency (US EPA) and other governmental agencies to assist in determining the probability and magnitude of deleterious effects of hazardous chemicals on plants and animals.
(11) Gibbs was sent off in the first half at Stamford Bridge for handball, despite replays clearly showing it was his team-mate Alex Oxlade-Chamberlain who illegally deflected an Eden Hazard shot.
(12) The purification and concentration of these viruses in their monomeric forms is hazardous when conventional "tube" rotors are used since they invariably result in dissociation and aggregation of the virus particles.
(13) The authors consider that this device increases safety during this potentially hazardous procedure by eliminating the flammable polyvinyl chloride endotracheal tube and cottonoid packings most frequently used during this procedure.
(14) The identifiable causes of child drowning are absence of a safety barrier or fence around the water hazard, non-supervision of a child, a parental "vulnerable period", an inadequate safety barrier, and tempting objects in or on the water.
(15) However, occupational hazards, toxic and iatrogenic drug-induced aetiologies should not be overlooked.
(16) Persons responsible for animals may be unaware of the potential hazard or lack good judgment in the use of these chemicals.
(17) This has been infrequently reported to occur during general anesthesia and to cause respiratory embarrassment, representing a significant hazard.
(18) Unvaccinated children had a mortality hazard ratio of 3.0 compared with vaccinated children (P = .002), indicating a protective efficacy against death of 66% (CI 32%-83%) of measles vaccination.
(19) Gallium arsenide has proved to be an ideal substrate material for some uses but is associated with unique health hazards.
(20) Recognition, evaluation and control of hazards were carried out in a typical case where chromium was the major pollutant.