(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.
Mischievous
Definition:
(a.) Causing mischief; harmful; hurtful; -- now often applied where the evil is done carelessly or in sport; as, a mischievous child.
Example Sentences:
(1) The appearance of a band with lean, spiky songs, high cheekbones and excellent trousers was therefore the cause of considerable excitement, to which they mischievously alluded in the title of their debut album, Is This It.
(2) In response, the ANC secretary-general, Gwede Mantashe, said the critics were "mischievous" and the party should be allowed to run its own affairs.
(3) You don't have to be against the minority of SAHMBY (stay-at-home mothers by choice) to consider their involvement in this debate a complete, and sometimes mischievous, distraction.
(4) It hasn’t helped that one mischievous customer appears to have added a crease to the carton on the right to make it look even more like a penis.
(5) "I want to reassure my friend Eduardo that there is no chance of me hanging on to the Olympic flag at the closing ceremony", joked Johnson, before adding mischievously "As protocol demands I will be handing it over to Eduardo — probably."
(6) Three seasons in the media spotlight in Madrid have clearly done him no harm, and when a potentially mischievous question comes along about England temporarily transferring their support to Wales he defuses it politely and diplomatically.
(7) Moir, who has won a British Press Award, made a statement defending her column late on Friday, saying it was not her intention to offend, blaming a "heavily orchestrated internet campaign" for the furore and adding that it was "mischievous in the extreme to suggest that my article has homophobic and bigoted undertones".
(8) The final seconds of the movie are the most memorable, in which Smokey assures Big Worm he’s going to rehab, before hanging up the phone and lighting a joint with a mischievous grin to the camera.
(9) These fairies have sharp, mischievous features, quite different from the later fairies of Bethlem.
(10) Prime ministers are very useful to a treasurer,” Keating said mischievously, and Hawke and I had a great relationship until he “produced a nasty little book”.
(11) The first point to note is that Sally's spirit guides were in a particularly mischievous mood during the reading, because they persuaded Sally to make statements such as: Sally: Is there the name Robyn?
(12) What is not so well known is his mischievous streak.
(13) The moderator of the conference demanded that Aydin switch to Turkish; a fellow Kurd came mischievously onto the platform to translate.
(14) Richard E Grant and Anna Chancellor join the cast, with Grant playing a guest of the Granthams and Chancellor the mischievous Lady Anstruther.
(15) At the time, a friend of Rennard told the BBC the "shocking and mischievous" leak was "in total defiance of fair process" and had caused great distress to the peer.
(16) Outside of the octagon, Bisping possesses the demeanour of an oversized Ricky Hatton - all mischievous grins, wisecracks and gentle ribbing of his sparring partners.
(17) Updated at 10.58am BST 10.55am BST Is the chancellor being too dramatic by declaring this morning that NO Help To Buy mortgages can be granted at more than 4.5 times the borrowers' income, asks a mischievous Robert Peston.
(18) He bubbles with mischievous excitement, recounting the range of thugs, creeps and gorgeous males who fell under his spell ("It was like a conduit had opened").
(19) Raphael wrote: “We believe our audience is sophisticated enough to accept a broad range of viewpoints, and we are loth to censor or avoid significant works of literature because they might be controversial.” BBC Radio 4 Publicity said online: “In Hilary Mantel’s mischievous story, a knock at the door announces an unexpected visitor who has plans to alter the course of history as people know it.
(20) For his part, Mr Taleb may have felt mischievously reported.