(1) Structurally altered polymorphic variants with reduced activity, such as tetrameric interface mutant Ile-58 to Thr, may produce not only an early selective advantage, through enhanced cytotoxicity of tumor necrosis factor for virus-infected cells, but also detrimental effects from increased mitochondrial oxidative damage, contributing to degenerative conditions, including diabetes, aging, and Parkinson's and Alzheimer's diseases.
(2) Samaras said: A "Grexit", as it is called, would be devastating for Greece and detrimental to Europe.
(3) The striking improvements in carbohydrate and lipid metabolism in diabetic and non-diabetic Aborigines after a temporary reversion to a traditional hunter-gatherer lifestyle highlight the potentially reversible nature of the detrimental effects of lifestyle change, particularly in young people who have not yet developed diabetes.
(4) A murine model system was developed to determine whether ionizing radiation has a detrimental influence on thymic epithelium, cell function.
(5) The aim of this study was determine if functional adaptation of NHP and HB position to these detrimental conditions could be observed, using Bonferonni probabilities, in a cephalometric comparison of 38 SAS adults in the wakeful state and a control group of 38 healthy adults.
(6) Together, they dispel the myth that changing initial responses more often is detrimental than beneficial.
(7) Also, studies on the simulated cumulative effect of background radiation during storage failed to find any detrimental effect when embryos were exposed to the equivalent of about 2000 years of background radiation.
(8) The author then describes new approaches to improving the vocational integration of persons with epilepsy, by focussing on the one hand on extending the range of occupational assessment, and the adoption of new job placement assessment, and the adoption of new job placement strategies on the other, which concurrently seek to influence those factors that are detrimental to the occupational outlook of the person with a seizure disorder (notably frequent seizures, psychiatric problems, low educational levels, negative employer attitudes).
(9) The rationale for the inclusion of Mg in cardioplegic solutions therefore lies not in its cardioplegic properties, but in its ability to influence other cellular events such as the loss of Mg and K and perhaps to counter the detrimental effects of ischemia by antagonizing calcium (Ca) overload.
(10) Alternatively, increasing this ratio may permit embryos to reduce the concentration of a substance detrimental to their growth.
(11) Because NMDA receptor antagonists impede certain kinds of learning, and because motor recovery after sensorimotor cortex injury in the rat is dependent on post-lesion experience, we hypothesized that treatment with MK-801 after focal brain injury would be detrimental.
(12) Student participation in school-based suicide prevention programs, however, was associated with a detrimental effect on state teenage suicide rates.
(13) Aggressive or improper toothbrushing techniques may have a detrimental impact on the gingiva.
(14) On this basis we tried to change the milieu on a 26-bed therapeutic community ward which proved to have pseudo-groups and a detrimental ward atmosphere.
(15) In a pediatric critical care environment with skilled ongoing nursing care, the axillary artery can be used as a site for intraarterial monitoring in pediatric patients without a detrimental effect on concurrent or future blood pressure monitoring.
(16) These data suggest that sCR1 inhibits the Arthus reaction by interrupting the activation of the C cascade, hence limiting the detrimental immune complex-induced tissue damage in vivo.
(17) Unreasonable expectations and expansion of the health sector have spawned counterproductive effects which are to some extent detrimental to public health.
(18) Falls among hospitalized patients are common occurrences and can have detrimental effects on patient outcomes.
(19) Nylon drains are available in any operating room, and have no detrimental effects on the grafted skin.
(20) Focal cerebral ischemia initiates multiple detrimental effects in the brain.
Shoddy
Definition:
(v. t.) A fibrous material obtained by "deviling," or tearing into fibers, refuse woolen goods, old stockings, rags, druggets, etc. See Mungo.
(v. t.) A fabric of inferior quality made of, or containing a large amount of, shoddy.
(a.) Made wholly or in part of shoddy; containing shoddy; as, shoddy cloth; shoddy blankets; hence, colloquially, not genuine; sham; pretentious; as, shoddy aristocracy.
Example Sentences:
(1) They demonstrate, at worst, a cavalier prejudice against work that the correspondents deemed shoddy.
(2) And you would be a shoddy parent indeed if you had no problem with your child slaving for the minimum wage when you could help them achieve something more remunerative.
(3) What makes Eastleigh so interesting now is that it's a test of how absorption into the national, rather than local, game – with all the shoddy compromises that coalition requires – has changed the way Liberal Democrat MPs operate and changed their relationship with what used to be their people.
(4) The film also brings in Weerasethakul's own family history, and childhood memories of lo-fi horror movies and TV shows (lots of red-eyed monsters, shot in darkness to cover up their shoddy costumes).
(5) Fifteen Indians lost their sight after a doctor used suspected infected equipment to remove cataracts at a free eye surgery camp, the latest incident to highlight the dangers of shoddy medical treatment in the country.
(6) That's interesting, because I've never seen a Financial Times reporter write a shoddy article about the markets and then justify it by saying, "it's not my fault, it's the FTSE 100 – it's just too hard!".
(7) Sarah Jackson Chief executive officer, Working Families • Your endorsement of Labour proposals to force employers to offer steady work to zero-hours staff after six months is shoddy thinking.
(8) They thoroughly deserve their place even if they had to survive a late scare here, largely because of shoddy finishing prior to that.
(9) Since he joined Dixons from Tesco in 2007 he's made a good stab at repairing the chain's reputation for shoddy customer service, and improving its financial position, leaving the company confident it can repay a make-or-break £160m bond later this year.
(10) Throw in delays and deaths at stadium construction sites, shoddy infrastructure, high murder rates and a presidential election, and it is clear that Brazil could come out of 2014 looking a lot worse than it went in.
(11) Besides Mohammed Ali and Mousani, the other men have all taken shoddy and overloaded boats that capsized, been caught by the authorities and escaped detention – all multiple times.
(12) Never mind the ubiquitous construction cranes or gangland-style killings, accusations of corruption and shoddy work – for now the city is basking in the glory of being home to one of the world's longest suspension bridges.
(13) In the 17th and 18th centuries, British shopkeepers tried to pass off shoddy English-made textiles as Indian in order to charge higher prices for them.
(14) Paul Smaldino, a cognitive scientist who led the work at the University of California, Merced, said: “As long as the incentives are in place that reward publishing novel, surprising results, often and in high-visibility journals above other, more nuanced aspects of science, shoddy practices that maximise one’s ability to do so will run rampant.” Study delivers bleak verdict on validity of psychology experiment results Read more The paper comes as psychologists and biomedical scientists are grappling with an apparent replication crisis , in which many high profile results have been shown to be unreliable.
(15) Councils already struggle to keep tabs on unscrupulous landlords and shoddy properties, she says.
(16) Elderly people have been living in “grim, shoddy and unsafe” conditions in four care homes run by a private company in Cornwall , the health and social care watchdog has found.
(17) Many teachers earn only $630 (£387) monthly, forcing them to do extra jobs, facilities were often shoddy and there was a shortage of instruments, said Juan Carlos Hernández, a veteran instructor.
(18) There is also this film on YouTube , which is far from slick – indeed it's annoyingly shoddy – but it does give a good summary of Freud's influences and development.
(19) England have requested a report from Fifa on the state of the pitch at the Arena da Amazônia, where they kick off their World Cup campaign against Italy on Saturday, amid concerns that the turf is worn and in shoddy condition.
(20) Anchoring the mood was the fact John Terry sustained ankle damage on a shoddy pitch.