(v. t.) To free from that which infolds or envelops; to unfold; to lay open by degrees or in detail; to make visible or known; to disclose; to produce or give forth; as, to develop theories; a motor that develops 100 horse power.
(v. t.) To unfold gradually, as a flower from a bud; hence, to bring through a succession of states or stages, each of which is preparatory to the next; to form or expand by a process of growth; to cause to change gradually from an embryo, or a lower state, to a higher state or form of being; as, sunshine and rain develop the bud into a flower; to develop the mind.
(v. t.) To advance; to further; to prefect; to make to increase; to promote the growth of.
(v. t.) To change the form of, as of an algebraic expression, by executing certain indicated operations without changing the value.
(v. t.) To cause to become visible, as an invisible or latent image upon plate, by submitting it to chemical agents; to bring to view.
(v. i.) To go through a process of natural evolution or growth, by successive changes from a less perfect to a more perfect or more highly organized state; to advance from a simpler form of existence to one more complex either in structure or function; as, a blossom develops from a bud; the seed develops into a plant; the embryo develops into a well-formed animal; the mind develops year by year.
(v. i.) To become apparent gradually; as, a picture on sensitive paper develops on the application of heat; the plans of the conspirators develop.
Example Sentences:
(1) Without medication atypical ventricular tachycardia develops, in the author's opinion, most probably when bradycardia has persisted for a prolonged period.
(2) By presenting the case history of a man who successively developed facial and trigeminal neural dysfunction after Mohs chemosurgery of a PCSCC, this paper documents histologically the occurrence of such neural invasion, and illustrates the utility of gadolinium-enhanced magnetic resonance scanning in patient management.
(3) A 2.5-month-old child with cyanotic heart disease who required long-term PGE1 infusions; developed widespread periosteal reactions during the course of therapy.
(4) An automated continuous flow sample cleanup system intended for rapid screening of foods for pesticide residues in fresh and processed vegetables has been developed.
(5) Clinical signs of disease developed as early as 15 days after transition to the experimental diets and included impaired vision, decreased response to external stimuli, and abnormal gait.
(6) In addition, this pretreatment protocol did not modify the recipient immune response against B-lymphocyte alloantigens which developed in unsuccessful transplants.
(7) He is also the foremost theorist of the Tijuana-San Diego border in terms of what happens when the urban culture of the developing world collides with that of the developed world.
(8) A new balloon catheter has been developed for angioplasty.
(9) It is followed by rapid neurobehavioral deterioration in late infancy or early childhood, a developmental arrest, plateauing, and then either a course of retarded development or continued deterioration.
(10) Oculomotor paresis with cyclic spasms is a rare syndrome, usually noticeable at birth or developing during the first year of life.
(11) A new and simple method of serotyping campylobacters has been developed which utilises co-agglutination to detect the presence of heat-stable antigens.
(12) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(13) In some cervical nodes, a few follicles, lymphocyte clusters, and a well-developed plasmocyte population were also present.
(14) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(15) beta-Endorphin blocked the development of fighting responses when a low footshock intensity was used, but facilitated it when a high shock intensity was delivered.
(16) Some commentators have described his ship, now facing more delays after a decade in development, as little more than a Heath Robinson machine.
(17) To examine the central nervous system regulation of duodenal bicarbonate secretion, an animal model was developed that allowed cerebroventricular and intravenous injections as well as collection of duodenal perfusates in awake, freely moving rats.
(18) Since 1987, it has become possible to obtain immature ova from the living animal and to let them mature, fertilize and develop into embryos capable of transplantation outside the body.
(19) One developed recurrent dislocation of the shoulder.
(20) The planned development (october 1989) is also depicted.
Refine
Definition:
(v. t.) To reduce to a fine, unmixed, or pure state; to free from impurities; to free from dross or alloy; to separate from extraneous matter; to purify; to defecate; as, to refine gold or silver; to refine iron; to refine wine or sugar.
(v. t.) To purify from what is gross, coarse, vulgar, inelegant, low, and the like; to make elegant or exellent; to polish; as, to refine the manners, the language, the style, the taste, the intellect, or the moral feelings.
(v. i.) To become pure; to be cleared of feculent matter.
(v. i.) To improve in accuracy, delicacy, or excellence.
(v. i.) To affect nicety or subtilty in thought or language.
Example Sentences:
(1) The patients had a high AP, consumed more alcohol, were more well-fed, older and consumed more refined carbohydrates per 1 kg bw and less cholesterol and vegetable protein.
(2) After restrained least-squares refinement of the enzyme-substrate complex with the riboflavin omitted from the model, additional electron density appeared near the pyrophosphate, which indicated the presence of an ADPR molecule in the FAD binding site of PHBH.
(3) Well-refined x-ray structures of the liganded forms of the wild-type and a mutant protein isolated from a strain defective in chemotaxis but fully competent in transport have provided a molecular view of the sugar-binding site and of a site for interacting with the Trg transmembrane signal transducer.
(4) To meet these prerequisites we have introduced some technical refinements: (1) computer-controlled rectilinear translations of the target in combination with different angular positions of the source and (2) computer-controlled rotations of the target around a vertical axis in combination with different angular positions of the source.
(5) Percutaneous transhepatic biliary drainage (PTBD) was conceptualized more than 35 years ago, but its clinical application only flourished in the past 10 years after a number of technical refinements.
(6) In 1984 the press-fit condylar knee was first introduced and was intended to provide a condylar knee system primarily for posterior cruciate retention that addressed refinements in metallurgy, prosthetic geometry and sizing, cementless fixation, inventory management, and instrumentation.
(7) Obviously, the sheer number of lasers being used both clinically and experimentally indicates a great potential for further advancement and refinement in technique and surgical outcomes.
(8) Phases from x-ray structure factors (R = 0.43) computed from this model were then used in the calculation of another electron density map against which the model was further refined.
(9) Staging classifications are being refined to reflect increasing knowledge of important prognostic indicators, e.g., absence or presence of lymph node involvement, pattern of lymph node involvement, and absence or presence of visceral disease.
(10) The ordered aspect of the genetic code table makes this result a plausible starting point for studies of the origin and evolution of the genetic code: these could include, besides a more refined optimization principle at the logical level, some effects more directly related to the physico-chemical context, and the construction of realistic models incorporating both aspects.
(11) The structure of Mn(III) superoxide dismutase (Mn(III)SOD) from Thermus thermophilus, a tetramer of chains 203 residues in length, has been refined by restrained least-squares methods.
(12) Based on the refined atomic coordinates of the tRNAphe in the orthorhombic crystal, on the recent advances in the distance dependence of the ring-current magnetic field effects and on the adopted values for the isolated hydrogen-bonded NH resonances, a computed spectrum consisting of 23 protons was constructed.
(13) It can be used as a simple screening procedure to help determine which of many possible anthelmintic control strategies should be selected for more detailed examination in the field, and it provides a theoretical framework within which ideas concerning the epidemiology of parasitic gastroenteritis can be assessed and refined.
(14) The advances in lid and orbital surgery are due to the improvements made in diagnostic equipment and to technical refinements.
(15) The group’s refining business performed better than expected, more than doubling profit to $2.2bn from $1bn.
(16) They also suggest that both the migration of cortical neurons on glia and the refinement of the mapping between the peripheral whisker field and its cortical representation may depend upon the distribution of substrate adhesion molecules.
(17) Thus the present study gives support for a protective effect associated with a fiber-rich or vegetable-rich diet, while it indicates that frequent consumption of refined starchy foods, eggs and fat-rich foods such as cheese and red meat is a risk factor for colo-rectal cancer.
(18) Synthesis and discussion is focused on five major areas in which gerontological continuity and change are evidenced: 1) transformation of basic themes over time; 2) gerontology's identity crisis; 3) the social ideology of gerontology; 4) evolution and refinement of gerontological ideas and methods; and 5) temporal frameworks.
(19) The course content and format were refined after 11 pharmacists completed a pilot program.
(20) This has led to important advances in our understanding of the mechanism of axonal guidance, the physiology of neurotrophic factors and the establishment and refinement of neural connections.