(v. t.) To free from that which infolds or envelops; to unfold; to lay open by degrees or in detail; to make visible or known; to disclose; to produce or give forth; as, to develop theories; a motor that develops 100 horse power.
(v. t.) To unfold gradually, as a flower from a bud; hence, to bring through a succession of states or stages, each of which is preparatory to the next; to form or expand by a process of growth; to cause to change gradually from an embryo, or a lower state, to a higher state or form of being; as, sunshine and rain develop the bud into a flower; to develop the mind.
(v. t.) To advance; to further; to prefect; to make to increase; to promote the growth of.
(v. t.) To change the form of, as of an algebraic expression, by executing certain indicated operations without changing the value.
(v. t.) To cause to become visible, as an invisible or latent image upon plate, by submitting it to chemical agents; to bring to view.
(v. i.) To go through a process of natural evolution or growth, by successive changes from a less perfect to a more perfect or more highly organized state; to advance from a simpler form of existence to one more complex either in structure or function; as, a blossom develops from a bud; the seed develops into a plant; the embryo develops into a well-formed animal; the mind develops year by year.
(v. i.) To become apparent gradually; as, a picture on sensitive paper develops on the application of heat; the plans of the conspirators develop.
Example Sentences:
(1) Without medication atypical ventricular tachycardia develops, in the author's opinion, most probably when bradycardia has persisted for a prolonged period.
(2) By presenting the case history of a man who successively developed facial and trigeminal neural dysfunction after Mohs chemosurgery of a PCSCC, this paper documents histologically the occurrence of such neural invasion, and illustrates the utility of gadolinium-enhanced magnetic resonance scanning in patient management.
(3) A 2.5-month-old child with cyanotic heart disease who required long-term PGE1 infusions; developed widespread periosteal reactions during the course of therapy.
(4) An automated continuous flow sample cleanup system intended for rapid screening of foods for pesticide residues in fresh and processed vegetables has been developed.
(5) Clinical signs of disease developed as early as 15 days after transition to the experimental diets and included impaired vision, decreased response to external stimuli, and abnormal gait.
(6) In addition, this pretreatment protocol did not modify the recipient immune response against B-lymphocyte alloantigens which developed in unsuccessful transplants.
(7) He is also the foremost theorist of the Tijuana-San Diego border in terms of what happens when the urban culture of the developing world collides with that of the developed world.
(8) A new balloon catheter has been developed for angioplasty.
(9) It is followed by rapid neurobehavioral deterioration in late infancy or early childhood, a developmental arrest, plateauing, and then either a course of retarded development or continued deterioration.
(10) Oculomotor paresis with cyclic spasms is a rare syndrome, usually noticeable at birth or developing during the first year of life.
(11) A new and simple method of serotyping campylobacters has been developed which utilises co-agglutination to detect the presence of heat-stable antigens.
(12) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(13) In some cervical nodes, a few follicles, lymphocyte clusters, and a well-developed plasmocyte population were also present.
(14) We determined whether serological investigations can assist to distinguish between chronic idiopathic autoimmune thrombocytopenia (cAITP) and immune-mediated thrombocytopenia in patients at risk to develop systemic lupus erythematosus (SLE); 82 patients were seen in this institution for the evaluation of immune thrombocytopenia.
(15) beta-Endorphin blocked the development of fighting responses when a low footshock intensity was used, but facilitated it when a high shock intensity was delivered.
(16) Some commentators have described his ship, now facing more delays after a decade in development, as little more than a Heath Robinson machine.
(17) To examine the central nervous system regulation of duodenal bicarbonate secretion, an animal model was developed that allowed cerebroventricular and intravenous injections as well as collection of duodenal perfusates in awake, freely moving rats.
(18) Since 1987, it has become possible to obtain immature ova from the living animal and to let them mature, fertilize and develop into embryos capable of transplantation outside the body.
(19) One developed recurrent dislocation of the shoulder.
(20) The planned development (october 1989) is also depicted.
Unfold
Definition:
(v. t.) To open the folds of; to expand; to spread out; as, to unfold a tablecloth.
(v. t.) To open, as anything covered or close; to lay open to view or contemplation; to bring out in all the details, or by successive development; to display; to disclose; to reveal; to elucidate; to explain; as, to unfold one's designs; to unfold the principles of a science.
(v. t.) To release from a fold or pen; as, to unfold sheep.
(v. i.) To open; to expand; to become disclosed or developed.
Example Sentences:
(1) The estimated DNA compaction ratio (approximately 3-fold) is consistent with a significant degree of nucleosome unfolding in the hyperstimulated BR genes.
(2) This formalism allows resolution of the intrinsic protein folding-unfolding parameters (enthalpy, entropy, and heat capacity changes) as well as the ligand interaction parameters (binding stoichiometry, enthalpy, entropy, and heat capacity changes).
(3) The kinetics of inactivation of the Mg(2+)-containing enzyme in 8 M-urea at higher temperatures suggest a partially unfolded Mg-A-B* dimer intermediate with 50% activity, followed by irreversible inactivation coincident with the appearance of unfolded monomer.
(4) When RNAase is partially unfolded Au(III) causes oxidation of methionines to the sulphoxide, and leads to almost complete unfolding (at molar equivalent ratios).
(5) In the context of a simplified diamond lattice model of a six-member, Greek key beta-barrel protein that is closely related in topology to plastocyanin, the nature of the folding and unfolding pathways have been investigated using dynamic Monte Carlo techniques.
(6) The efficiency of energy transfer between probes attached to residues 1 and 15 in the reduced state is higher than that found for the same pair of sites in the native state or reduced unfolded (in 6 M Gdn.HCl) state.
(7) Coombs's theory of data (1952, 1964) and his unfolding theory of preferential choice (1950, 1964) provided the conceptualization of metacognition in this psychophysical task context.
(8) Yet what has been unfolding in the past 15 months or so should make even the most ardent pro-European think about an orderly mechanism for making member states exit: the euro crisis and, less obviously, Hungary's backsliding from liberal democracy to a soft form of authoritarianism, or what an American paper recently called " Lukashenko lite ".
(9) Circular dichroism studies show that the conformation of each subunit is unusually resistant to change in 6 M guanidine HC1 at 25 degrees C. This suggests that exposure of the epitope by dissociation requires minimal or no unfolding of subunits.
(10) The data relative to the guanidine-induced unfolding show a sigmoidal increase of the distribution width, which is due to the transition of the protein structure from the native to the random-coiled state.
(11) The data suggest that the assessment of early trauma needs to employ a variety of measures, especially those which are related to the unfolding skills appropriate for the particular age group studied.
(12) In contrast to the biphasic unfolding of the wild-type nuclease, the unfolding of the mutant is represented by a single-phase reaction, indicating that the biphasic unfolding for the wild-type protein is caused by cis-trans isomerization about the prolyl peptide bond in the native state.
(13) 4) The unfolded map diagnosis with apical display obtained from long-axis tomogram was useful to diagnose left anterior descending coronary (LAD) lesion, which improve not only the sensitivity of LAD but also specificity of right coronary artery single vessel disease.
(14) The replacement of Arg171 by Tyr stabilizes the enzyme against thermal inactivation and unfolding.
(15) These findings and the dense structure of the scleral spur suggest that in monkey eyes, and at least in some human eyes, contraction of the ciliary muscle causes unfolding of the trabecular meshwork, not so much through the movement of the scleral spur as by movement of the interconnecting trabecular beams and fibers.
(16) The principal parameter under scrutiny was the denaturing or unfolding effects caused by the interaction of the protein with the adsorptive surfaces in each assay system.
(17) For here we see the depravity to which man can sink, the barbarity that unfolds when we begin to see our fellow human beings as somehow less than us, less worthy of dignity and life; we see how evil can, for a moment in time, triumph when good people do nothing."
(18) In contrast, import of the surface-bound unfolded precursor requires ATP, but no potential; it is accompanied by a refolding inside the mitochondria.
(19) These experiments show that yeast cells can activate a transcription factor that stimulates expression of a nuclear gene in response to the accumulation of unfolded proteins in another cellular compartment.
(20) In the present study, the reversibility of the unfolding-refolding process induced by guanidine hydrochloride was investigated for the intact protein and the isolated domains.