(1) Thus the innocuousness and ubiquitous availability of dextromethorphan render it attractive for worldwide pharmacogenetic investigations in man.
(2) The effects of both opioid (morphine and dihydrocodeine) and nonopioid (dextromethorphan and noscapine) antitussive drugs were diminished in morphine-dependent rats.
(3) In addition, the previous blockade by ketamine and dextromethorphan of NMDA receptors has been shown to intensify the naloxone-elicited morphine abstinence syndrome.
(4) Protection by codeine 20 mg, dextromethorphan 30 mg, noscapine 30 mg, and placebo against citric acid-induced cough was determined in eighteen healthy subjects.
(5) The K+ outflow via nicotinic ACh receptor cation channels was inhibited by various psychotomimetic sigma ligands in the sequence of PCP, dextromethorphan >> DTG, MK 801, (+)SKF10047 >> (+)3-PPP.
(6) In a preliminary study, different rates of N-, O- and N,O- demethylation of dextromethorphan to yield D-methoxymorphinane, dextrorphan and D-hydroxymorphinane, respectively, were found in extensive- (Sprague-Dawley) and poor-metabolizer (female dark Agouti) rat strains.
(7) Codeine and dextromethorphan were N-demethylated in human foetal liver microsomes at high rates which were close to the activities in adult livers.
(8) The purpose of this study was to determine whether dextromethorphan, an opioid class antitussive, prevents hypoxia-induced loss of nerve function in an in vitro hippocampal slice preparation.
(9) The concentrations of dextrorphan were 170 times higher than the concentrations of dextromethorphan.
(10) Anticonvulsant and neuroprotective properties have been demonstrated, and treatment with dextromethorphan has been shown to improve the cerebrovascular and functional consequences of global cerebral ischemia.
(11) Both bufuralol and dextromethorphan are well-known substrates of cytochrome P450IID6.
(12) Male and female rats exhibited striking differences in their ability to metabolize dextromethorphan.
(13) Moreover, genotypic identification of heterozygous and homozygous extensive metabolizer subjects did not predict CYP2D6 activity, as determined by dextromethorphan and encainide metabolic ratios, or encainide response, as determined by intraventricular and atrioventricular changes.
(14) The N-methyl-D-aspartate (NMDA) antagonists dextromethorphan (DM) and dextrorphan (DX) were found to reduce significantly neocortical severe ischemic neuronal damage (SIND) when administered in a delayed fashion after the ischemic insult.
(15) The anticonvulsant potency of these compounds, (+)-5-methyl-10,11- dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801) greater than dextrorphan greater than or equal to 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP) greater than dextromethorphan greater than (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P less than 0.01) with their respective affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes.
(16) In the dextromethorphan-treated animals, 90% of the rats survived compared with 47% of the untreated animals (p less than 0.05).
(17) A centrally acting antitussive agent dextromethorphan (DM) was tested to determine its possible interaction with naloxone in rats responding under a fixed-interval schedule of positive reinforcement.
(18) Simple, sensitive and selective enzyme immunoassays (ELISA) for monitoring urinary dextromethorphan and its major metabolite, dextrorphan, were developed.
(19) The results indicate that salbutamol has antitussive action enhancing the effect of plain dextromethorphan.
(20) In the present investigation, the effects of sigma ligands [WY-47384 [8-fluoro-2,3,4,5-tetrahydro-2[3-(3-pyridinyl)propyl)1H- pyrido(4,3b)indole], (+)-pentazocine, (+)-SFK 10,047 (N-allylnormetazocine), mafoprazine, opipramol, dextromethorphan, dextrorphan, (+)-3-PPP [3-(3-hydroxyphenyl)-N-propylpiperidine], (-)-butaclamol, DTG [1,3-di(2-tolyl)guanidine], rimcazole, ifenprodil and BMY-14802 [alpha-(fluorophenyl)-4-(5-fluoropyrimidinyl)-1-piperazine butanol]] on harmaline-, pentylenetetrazol (PTZ)-, methamphetamine (MA)- and D-serine-induced increases in mouse cerebellar levels of cGMP were determined.
Drank
Definition:
(imp.) of Drink.
(n.) Wild oats, or darnel grass. See Drake a plant.
(imp.) of Drink
Example Sentences:
(1) Basal plasma levels of oxytocin were found to be low in sodium-deficient adrenalectomized rats and in intact animals treated daily with desoxycorticosterone acetate, both of which groups drank large amounts of NaCl solution, whereas basal plasma levels of arginine vasopressin were neither stimulated nor suppressed.
(2) The onset of tolerance to morphine analgesia was studied in 34 female Wistar rats immediately after they drank a dextrose-saccharin cocktail or tap water for 6 or 24 hours.
(3) The rats provided with sodium barbiturate-supplemented water developed more intestinal tumors than did those that drank drug-free water.
(4) ANG II given as early as 10 days after surgery, and they drank reliably and vigorously but less in total volume to 100 ng i.c.v.
(5) Subjects reported in a diary everything they either ate or drank for seven consecutive days.
(6) When the dogs drank either H2O or NaCl,f increased significantly during the first minute after drinking.
(7) But identifying why I’m not sleeping well after I’ve eaten too much, drank something or not exercised enough, then it becomes useful to change habits and do something about the poor sleep.” Fitbit has one of the most advanced analysis platforms.
(8) Rats drank from a cup and were then injected with lithium chloride.
(9) No one would deny that Thomas drank too much or that he could be a troublesome drunk.
(10) When water was withheld for 15 min, but then allowed, rats drank the same total volume but c-fos expression was no longer inhibited in either the supraoptic nucleus or paraventricular nucleus.
(11) A case is described of a 30-year-old White male who drank 120 ml carbon tetrachloride (CCI4).
(12) Men drank more and they drank more often than women.
(13) Unilateral nephrectomy at the age of 80 days produced a slight BP increase in females irrespective of whether they drank water or 0.6% NaCl, but in males only if they drank 0.6% NaCl solution.
(14) Ninety percent of women drank alcohol at least once after the diagnosis of pregnancy.
(15) Their pattern of drinking was similar to that of other age groups, except for those over 65 years, who drank less.
(16) In particular, girls in the eighth grade showed less suitable behaviour in several fields: many of these drank alcohol and smoked tobacco.
(17) The rats that were injected with ibotenic acid during ketamine anesthesia drank significantly less than the control group when tested with 3% hypertonic saline but not when tested with angiotensin II.
(18) Females drank considerably less in this population; trends were similar although not of as great magnitude as those for males.
(19) Although natural killer cell activity was lower in patients who drank alcohol or had nodal metastases, no single clinical factor was predictive of deficient cytotoxic response.
(20) Abedi, too, smoked cannabis, drank and, according to at least one source, was known to the authorities for antisocial behaviour.