What's the difference between dextrorotary and levorotatory?
Dextrorotary
Definition:
(a.) See Dextrotatory.
Example Sentences:
(1) Cats were treated using a blinded protocol with either the dextrorotary or levorotary form of WIN 44,441-3 injected subcutaneously six hours after middle cerebral artery occlusion, followed by continuous subcutaneous infusion.
(2) Dextrorotary isomer activity is nonopiate or possibly nonspecific.
(3) The dextrorotary enantiomer of amlodipine, practically devoid of calcium channel blocking action, increased chloroquine accumulation inside the infected mouse erythrocytes and potentiated chloroquine action against the resistant strains of P. falciparum in vitro and P. yoelii in mice.
(4) The levorotary form acutely improved neurologic function in 90% of animals, whereas the dextrorotary form had no effect.
(5) The sigma site is a recently described binding site to which dextrorotary isomers of certain psychotomimetic benzomorphans bind specifically.
(6) The results of this study indicate that chloroquine potentiation of amlodipine is probably independent of calcium channels and that a combination therapy of the dextrorotary enantiomer of amlodipine and chloroquine might be a potentially useful therapeutic strategy against chloroquine-resistant falciparum malaria.
Levorotatory
Definition:
(a.) Turning or rotating the plane of polarization towards the left; levogyrate, as levulose, left-handed quartz crystals, etc.
Example Sentences:
(1) In addition, the inhibitory activity of these acyclic analogues was enantioselective, exhibiting a preference, similar to the parent vesamicol, for the levorotatory isomer [(-)-11a vs (+)-11a].
(2) The levorotatory form of 5-hydroxytryptophan significantly improved the ataxia score.
(3) The stereochemistry of this material was established by conversion to levorotatory methyl 4-phthalimido [4(-2)H] butyrate.
(4) Extraction and fractionation of Frullania tamarisci has given, as the only allergenic component isolated, a levorotatory crystalline sutbstance, the structure of which is demonstrated.
(5) As several reports in literature confirmed the greatest antineoplastic activity of L-form in animals, the suggestion of further clinical investigation of levorotatory form as a separate preparation has been put forward.
(6) The dextrorotatory enantiomer of fluoxetine was slightly more potent than the levorotatory enantiomer in antagonizing the depletion of brain serotonin by p-chloroamphetamine in rats.
(7) The levorotatory compounds of R configuration showed stronger protective and also therapeutic effect in different experimental arrhythmias.
(8) These data indicate that the beta 2-receptor agonistic and anti-permeability actions of terbutaline are found solely in the levorotatory enantiomer.
(9) In five cases in which the levorotatory form of 5-hydroxytryptophan therapy was maintained for 12 months, the effect continued progressively.
(10) Some features of cerebellar ataxia have been reported to regress partially with long-term administration of 5-hydroxytryptophan or levorotatory form of 5-hydroxytryptophan.
(11) The racemic N-alkyl derivatives are more active than the racemic or even the levorotatory N-benzyl compound.
(12) By the consecutive oxidation and hydrolysis reactions a levorotatory intermediate was formed, presumably (-)-2-oxo-4-hydroxy-4-carbohydroxy-5-ureido-imidazoline.
(13) It was shown that the stereodifferentiation of anti-tumor effect of enantiomers was not outstanding although quite consistently in favour of levorotatory forms.
(14) A similar, but less potent neuron-protective effect, was seen with the opioid levorotatory enantiomer of DX, levorphanol (ED50, 40 microM).
(15) Treponemycin is a crystalline light-yellow compound with an mp of 93 to 95 degrees C, levorotatory, and soluble in most organic solvents.
(16) In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.
(17) The therapeutic index of the racemic 13 and its levorotatory enantiomer was about 1.7 times higher than that for ifosfamide and about 2.7 times higher than that for cyclophosphamide.
(18) In a separate experiment, 100 micrograms of dextrorotatory and levorotatory gossypol was administered to male mice.
(19) Among these compounds, the levorotatory 3-acetyl-N-(cyclopropylmethyl)morphinan (12) was found to be an orally active analgesic, comparable in potency to morphine (1), yet only weakly able to substitute for morphine (1) in morphine-dependent rats.
(20) The dextrorotatory gossypol, both in rat and mice, had less pronounced effect on the histoarchitecture of the testis in comparison to racemic and levorotatory gossypol.