(n.) The passage of the corpuscular elements of the blood from the blood vessels into the surrounding tissues, without rupture of the walls of the blood vessels.
Example Sentences:
(1) Thrombospondin (TSP), a 450-kDa trimeric glycoprotein secreted by platelets and endothelial cells at sites of tissue injury or inflammation, may play an important role in polymorphonuclear leukocyte (PMN) adherence to blood vessel walls before diapedesis.
(2) Adherence of circulating neutrophils to the microvascular endothelium is the initial step in diapedesis, the process by which leukocytes migrate through blood vessels to accumulate at sites of cutaneous disease or injury.
(3) Adherence of PMNs to the endothelium and their subsequent diapedesis and egress to areas of infection are considered early vital events in the inflammatory process.
(4) Parietal thrombosis and leukocyte diapedesis were also observed in the aorta.
(5) The results of this preliminary study suggest that changes can be found in peripheral blood monocytes which might influence diapedesis and interaction with immune complexes.
(6) Intramammary infusion of saline containing .1% glycogen resulted in diapedesis of numerous leukocytes (93% polymorphonuclear leukocytes) into milk.
(7) The LTB4 generation following Tx-mimic was correlated (P less than 0.05, r = 0.70) with neutrophil diapedesis.
(8) Previously we reported that cultured endothelial cells (ECs) can promote or inhibit polymorphonuclear leukocyte (PMN) diapedesis and albumin permeability in vitro by altering monolayer intercellular integrity (an activity influenced by pretreatment with exogenous amines).
(9) At day four lymphocyte diapedesis through the venules becomes apparent.
(10) The infusion of prostacyclin prevented the formation of platelet aggregates and platelet diapedesis due to PAF-acether, but the morphological evidence of bronchial constriction was not modified.
(11) A model of leukocyte adhesion and invasion whereby activated leukocytes denature extracellular proteins during diapedesis, making them suitable for recognition by beta 2 integrins, is proposed.
(12) From the observations of others, it had appeared that the ultimate portal of entry into the central nervous system involved some type of cytolytic process; however, this study illustrates an action of simple diapedesis in which the organisms seek a pathway of least resistance; namely the naturally-occurring pial fenestrations.
(13) Early nodal PCV are distinguised from other nodal blood vessels by the presence of lymphocyte diapedesis and several luminal lymphocytes.
(14) Granulocyte diapedesis in response to the generation of defined chemotaxins such as leukotriene B4 (LTB4), 12(R)-hydroxyeicosatetraenoic acid [12(R)-HETE], C5a, platelet activating factor and others is a hallmark of the inflammatory process that is thought to contribute to the tissue pathology seen in a number of diseases.
(15) These data indicate that surface contact such as would occur during diapedesis and chemotaxis profoundly alters neutrophil behavior by an unknown mechanism and imply that observations made on polymorphonuclear leukocytes in suspension cannot be generalized to polymorphonuclear leukocytes in tissue.
(16) In both types of tumour growth this free blood was due to diapedesis of erythrocytes through tips of capillary sprouts which grow when neovascularization (angiogenesis) occurs in response to any suitable (non-neoplastic or neoplastic) stimulus.
(17) Thus, endothelial generation of superoxide radicals acts as a trigger mechanism for endothelial dysfunction which is then amplified by neutrophil adherence and diapedesis into the ischemic region enhancing post-reperfusion ischemic injury.
(18) It is concluded that exposure to LTB4 per se and the resulting leukocyte diapedesis are not structurally damaging to the vasculature.
(19) This study tests whether LTB4 is derived from PMNs and its role in mediating ischemic plasma-induced diapedesis.
(20) We examined the in vivo effects of a known phospholipase A2 inhibitor (mepacrine) and the two mast cell active agents (cyproheptadine and reserpine) on lung lavage fluid chemotactic capability, alveolar macrophage (AM) production of chemotactic factor(s), and neutrophil diapedesis.
Leucocyte
Definition:
(n.) A colorless corpuscle, as one of the white blood corpuscles, or those found in lymph, marrow of bone, connective tissue, etc.
Example Sentences:
(1) Glutathion peroxidase and p-phenylenediamide-mediated peroxidase (PPD-peroxidase) were normal in leucocytes of 1 HPS patient.
(2) In each subject, the activity in leucocytes of delta-aminolaevulinic acid (ALA) synthase increased and that of protoporphyrinogen (proto) oxidase decreased during the first week of therapy.
(3) For all the other drugs, skin tests and leucocyte histamine release were negative or unspecific.
(4) The serum of these patients caused mainly a fall of the bactericidal activity of the leucocytes, and this was caused more frequently by a deficit of the opsonizing factors than by the presence of inhibitor.
(5) Early diagnosis (fever, increase of leucocytes and toxic signs in differential blood count, thrombocythemia, decrease of anorganic phosphate), prophylaxis, and treatment are discussed.
(6) Around 10(7) leucocytes, corresponding to 1-10 ml blood, sufficed for the analysis.
(7) Even after injury to organs, LMWD infusion seems to be beneficial by significantly lowering leucocyte sequestration and could therefore be justified as an addition to the arsenal of interventions used in the treatment of endotoxemia.
(8) The sluggish flow which results from this vasoconstriction and high venous pressure leads to a haemoconcentration which reduces oedema formation but favours leucocyte and platelet sequestration within the microcirculation.
(9) 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals.
(10) The effect on milk yield, milk leucocyte concentration, and milk prolactin of dominance rank and introduction of "strange" cows into a group was studied.
(11) Several stages in its histogenesis may be discerned: I. focal necroses of hepatic cells associated with their invasion with lister Listeria; 2. appearance of cellular elements around the foci of necroses with subsequent formation of granulemas consisting mainly of leucocytes and lymphoid cells; 3. development of necrobiotic changes in the central areas of granulemas with concomitance of exudative processes; 4. organization of necrotic foci with subsequent scarring.
(12) Effects of anti-human pan-T-specific monoclonal antibodies of the Second International Workshop on Human Leucocyte Differentiation Antigens were investigated in a number of lymphocyte functional tests.
(13) These results suggest that besides the maternal leucocytes, sufficient trophoblast nucleated fetal cells can be obtained using cell enrichment by sorting.
(14) The rise in milk cell count after infusion of E. coli endotoxin was related to in vitro chemotactic activity of blood polymorphonuclear leucocytes (PMN).
(15) In neutrophilous peripheral blood leucocytes of healthy and leucotic cattle the PAS reaction attained the values of ++ to +++.
(16) No immunoreactive material was found in lysates of rabbit polymorphonuclear leucocyte granules with the specific antisera to rabbit fibroblast collagenase.
(17) Studies of peripheral blood leucocyte concentrates in patients with Hodgkin's disease showed two types of cells believed to be typical for the disease in a number of patients.
(18) In 20 patients with hyperthyroidism the behaviour of the agglomeration of leucocytes as well as of the adhesivity before and after the methimazol therapy was investigated.
(19) Large subsets of leucocytes were recently shown to express the low affinity receptor for the Fc portion of IgE.
(20) The leucocyte-migration-inhibition test demonstrates a cell-mediated immunological reaction to vascular wall antigens.