(a.) Having two acid hydrogen atoms capable of replacement by basic atoms or radicals, in forming salts; bibasic; -- said of acids, as oxalic or sulphuric acids. Cf. Diacid, Bibasic.
Example Sentences:
(1) It is concluded that in this cell type (i) somatostatin-14 is exclusively generated by dibasic cleavage at the Arg-2-Lys-1 site of the intact precursor with concomitant production of prosomatostatin[1-76], and (ii) no direct interactions between the monobasic and dibasic processing domains occur.
(2) Lysine uptake is inhibited by other dibasic amino acids, arginine and ornithine but not cystine.
(3) Translation of the cDNA revealed a 138-amino acid precursor consisting of the Mas-DH amino acid sequence bounded by dibasic amino acid processing sites, a putative signal sequence, and additional peptide sequence on either side of the Mas-DH coding sequence.
(4) Chromatographic separation was accomplished under isocratic conditions using a reversed-phase C-18 analytical column and mobile phase consisting of equal parts of 75 mM dibasic ammonium phosphate buffer (adjusted to pH 3.5 with phosphoric acid) and acetonitrile, with a detection wavelength of 220 nm.
(5) In the present series of experiments we have used a combined kinetic and genetic approach to establish that dibasic amino acids are also asc substrates, systems asc1 and asc2 representing the only mediated routes of cationic amino acid transport in horse erythrocytes.
(6) The biosynthesized precursor contains hormone and neurophysin sequences linked by a Gly-Lys-Arg sequence and undergoes enzymatic processing reactions which include endoproteolytic cleavage at the Lys-Arg dibasic sequence, carboxypeptidase B-like exoproteolytic cleavage, and enzymatic amidation.
(7) These results demonstrate that AtT-20 cells efficiently and accurately process prodynorphin at both dibasic sites and monobasic cleavage sites, indicating that the AtT-20 cells contain enzymes capable of cleaving the precursor not only at dibasic residues but also at monobasic residues.
(8) Maturation of pro-von Willebrand factor (vWF) to its active form requires proteolytic processing after a pair of dibasic amino acids (-LysArg-) at residue 763.
(9) From the deduced amino acid sequence, a biosynthetic pathway has been proposed that a prepro- form of porcine ET-1 is initially processed by dibasic pair proteolysis to a 39-amino acid intermediate form (big ET), which is then converted to ET-1 by specific proteolytic cleavage between Trp21 and Val22.
(10) Additional mitomycin admixtures were reconstituted with a buffer solution containing monobasic and dibasic sodium phosphate; these were diluted with 5% dextrose injection only.
(11) Lysine uptake is membrane potential sensitive and inhibitable by cystine, dibasic amino acids, and cycloleucine.
(12) The short form translation product should lack only an internal dibasic tetrapeptide.
(13) Esters of dibasic carboxylic acids show a minute but marked effect on the partition of proteins in general while malate and tartrate esters affect strongly the partition of chloroplast membranes.
(14) In addition to paired dibasic residues at the propeptide cleavage site, many proteins, including vWF, also contain an arginine at the P4 position.
(15) From these results it can be concluded that both the "dibasic" cleavage between vasopressin and MSEL-neurophysin and the "monobasic" cleavage between MSEL-neurophysin and copeptin occur within the granule compartment.
(16) Target compounds were made by treating N-(trifluoroacetyl)-14-halodaunorubicin (bromo or iodo) with monosodium salts of dibasic acids (malonic, succinic, glutaric, adipic, pimelic, azelaic, sebacic) in aqueous acetone.
(17) Lysobactin is a dibasic peptide with marked activity against Gram-positive aerobic and anaerobic bacteria.
(18) A small proportion of the VIP precursor followed a pathway in which the dibasic conversion site after PHM is not cleaved, as evidenced by the presence of a C-terminally extended form of PHM.
(19) These cultured cells, therefore, seem to be an excellent model system for the eventual elucidation of a) the inticacies of cystine metabolism and b) regulation of 1) the cystine-dibasic amino acid co-transporter system and 2) the development of the cysteine-glutamate anti-porter system.
(20) Lysine was reabsorped by a saturable transport system shared by the dibasics.
Metal
Definition:
(n.) An elementary substance, as sodium, calcium, or copper, whose oxide or hydroxide has basic rather than acid properties, as contrasted with the nonmetals, or metalloids. No sharp line can be drawn between the metals and nonmetals, and certain elements partake of both acid and basic qualities, as chromium, manganese, bismuth, etc.
(n.) Ore from which a metal is derived; -- so called by miners.
(n.) A mine from which ores are taken.
(n.) The substance of which anything is made; material; hence, constitutional disposition; character; temper.
(n.) Courage; spirit; mettle. See Mettle.
(n.) The broken stone used in macadamizing roads and ballasting railroads.
(n.) The effective power or caliber of guns carried by a vessel of war.
(n.) Glass in a state of fusion.
(n.) The rails of a railroad.
(v. t.) To cover with metal; as, to metal a ship's bottom; to metal a road.
Example Sentences:
(1) In this study of ten consecutive patients sustaining molten metal injuries to the lower extremity who were treated with excision and grafting, treatment with compression Unna paste boot was compared with that with conventional dressing.
(2) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(3) Our recurrences are due to local infections, removing the metal strut too early, i.e.
(4) "Acoustic" craters were produced by two laser pulses delivered into a saline-filled metal fiber cap, which was placed in a mechanically drilled crater.
(5) These results indicate that the inhibition of CarAc by heavy metals occurs by binding of the sulfhydryl on the enzyme by the metals.
(6) The consequences of proved hypersensitivity in patients with metal-to-plastic prostheses, either present prior to insertion of the prosthesis or evoked by the implant material, are not known.
(7) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(8) EGTA was ineffective in removing calmodulin from particulate preparations, but treatment with the tervalent metal ion La3+ resulted in a loss of up to 98% of calmodulin activity from these preparations.
(9) Sift the cocoa powder over the top and lightly but thoroughly fold it in with the metal spoon.
(10) The results also suggest that both alkali metals most probably have been delivered to the suckling pups and some of their toxic effect was retarded.
(11) The radioprotective action in E. coli ATCC 9637 of ascorbate added to media containing the weak sensitizer, tetracycline (effect described by Pittillo and Lucas (1967)), was found to be dependent on the presence of metal catalysts of the autoxidation of ascorbate.
(12) This study introduces a simple in vitro arrangement to measure current densities of implant metals.
(13) A rubber cuff was fixed on the metal cylinder and let an opening of 8 cm, simulating the cervix uteri.
(14) Since the enzyme requires a metal ion (Co2+) we suggest that the RNA and heparin are inhibitory by virtue of their capacity to chelate the Co2+.
(15) Lesions of allergic contact type could not be induced in the oral mucosa to any of the metal salt preparations.
(16) As yet the observations demonstrate that workers exposed in their occupation to heavy metals (cadmium, lead, metalic mercury) and organic solvents should be subjected to special control for detection of renal changes.
(17) This study investigates the photoneutron field found in medical accelerator rooms with primary barriers constructed of metal slabs plus concrete.
(18) While a clearcut relationship cannot be established between heavy metal music and destructive behavior, evidence shows that such music promotes and supports patterns of drug abuse, promiscuous sexual activity, and violence.
(19) The physiologically important metal ion for catalysis is Mg2+; however, Mn2+ supports in vitro activity, though at a reduced level.
(20) We support the view that catalysis by metalloenzymes may be a reflection of the chemistry of the metal ion itself as a Lewis acid, and that perhaps too much emphasis has been placed on supposed special characteristics (such as strains, "entasis") of the enzyme-metal ion association.