(1) Expression of the DIT and DIT2 genes is restricted to sporulating cells, with the DIT1 transcripts accumulating at the time of prospore enclosure and just prior to the time of dityrosine biosynthesis.
(2) The volume fraction of synthetic organelles in smooth muscle cells from the DIT of both males and females is of a highly significant difference from the volume fraction of synthetic organelles in cells of the subjacent media.
(3) Urinary excretion of intact DIT was low, being less than 1% of the administered dose of exogenous DIT within 2 days.
(4) Our data confirm the in vivo generation of extrathyroidal DIT from T4 in the rat.
(5) In contrast, 52% of the iodine administered in the form of DIT was excreted in the urine in the same time interval.
(6) Short periods of loading do not alter deiodination of L-DIT in liver or kidney at all; but lead to significant elevation of L-T4-deiodination in liver tissue.
(7) DIT may play a central role in the regulation of energy expenditure and in the etiology of certain types of obesity.
(8) DIT and BAT are controlled by hormonal action: noradrenaline appears to be the primary activator of BAT and insulin may be required for DIT and may even activate thermogenesis.
(9) The levels of MIT, DIT, T3 and T4 in the thyroid, and T3, T4 and TSH in serum, and the amount of iodine transport and synthesis of organic iodine in thyroid were determined.
(10) Higher doses or longer periods of loading cause a significant rise of L-DIT-deiodination in liver and kidney, while the L-T4-deiodination in liver is significantly decreased and in kidney significantly elevated.
(11) The secretion of gastric acid in the peptic ulcer patients were examined by the dopamine infusion test (DIT).
(12) In rats hypothyroidized with methylthiouracil (MTU), methimazol (MMI), or radiothyroidectomy, the extent of deiodination for L-diiodotyrosine (L-DIT) and L-thyroxine (L-T4) was investigated in homogenate supernatants of liver and kidney.
(13) two pentapeptides, apparently of the sequence Tyr-Asn-Asx-Lys-Gly, isolated as the DIT and MIT derivatives.
(14) There was no significant correlation between sex, age, presence of diabetes, mode of dialysis, years of chronic renal failure, years of dialysis or years of aluminum ingestion and any neurologic or neurobehavioral measurement, serum aluminum level, or DIT.
(15) The carbonyl complexes were found to be efficient hepatobiliary agents and cleared more rapidly than the corresponding 99mTcN- and 99mTc(dit)-complexes.
(16) From the results of kinetic studies and RIA measurements, the fraction of circulating T4 converted to DIT was calculated to be 3.9-4.3%.
(17) While rT3 is elevated in almost all critically ill patients, the increase in DIT is indicative of severe infection.
(18) The reaction is effectively quenched by the antioxidant, 2,6-dit-butyl-4-hydroxymethyl phenol as well as by Mn+2 (10(-5)-10(-3)M).
(19) The relative affinity of T3, T4, rT3, MIT, and DIT were in good agreement with their biological activity.
(20) Splitting off of sialic acid diminishes thenumber of phenolic groups of tyrosine, MIT, DIT and T4, which dissociate below pH 12-5.