(v. t.) To distinguish or mark by a specific difference; to effect a difference in, as regards classification; to develop differential characteristics in; to specialize; to desynonymize.
(v. t.) To express the specific difference of; to describe the properties of (a thing) whereby it is differenced from another of the same class; to discriminate.
(v. t.) To obtain the differential, or differential coefficient, of; as, to differentiate an algebraic expression, or an equation.
(v. i.) To acquire a distinct and separate character.
Example Sentences:
(1) AEDs may also have differential effects on nighttime sleep.
(2) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
(3) We also show that proliferation of primary amnion cells is not dependent on a high c-fos expression, suggesting that the function of c-fos is more likely to be associated with other cellular functions in the differentiated amnion cell.
(4) The subcellular distribution of sialyltransferase and its product of action, sialic acid, was investigated in the undifferentiated cells of the rat intestinal crypts and compared with the pattern observed in the differentiated cells present in the surface epithelium.
(5) We have investigated the increase in the spcDNA population upon cycloheximide treatment of individual sequences, which are found to amplify differentially.
(6) Periosteal chondroma is an uncommon benign cartilagenous lesion, and its importance lies primarily in its characteristic radiographic and pathologic appearance which should be of assistance in the differential diagnosis of eccentric lesions of bones.
(7) The differential diagnosis is more complex in Hawaii due to the presence of granulomatous diseases such as tuberculosis and leprosy.
(8) At 48 h after pretreatment, a differential effect on the absorption of sulfanilamide and L-tryptophan was observed in in situ recirculation experiments.
(9) The results suggest differential regulation of IL-6 expression between fibroblasts and macrophages.
(10) Differentiation between these two types of lesions is of utmost importance since the surgical approach will be different.
(11) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
(12) Dibutyryl cyclic AMP (dbcAMP) treatment of Neuro 2A neuroblastoma cells induces cell differentiation and neurite outgrowth.
(13) This experimental system allows separation of three B lymphocyte developmental stages: early differentiation in vitro, progression to IgM secretion in vivo, and late differentiation dependent upon mature T lymphocytes in vivo.
(14) A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness.
(15) SD is shown to have therapeutic and differential diagnostic significance in varying pathological conditions of cerebral dopaminergic systems.
(16) Aside from these characteristic findings of HCC, it was important to reveal the following features for the diagnosis of well differentiated type of small HCC: variable thickening or distortion of trabecular structure in association with nuclear crowding, acinar formation, selective cytoplasmic accumulation of Mallory bodies, nuclear abnormalities consisting of thickening of nucleolus, hepatic cords in close contact with bile ducts or blood vessels, and hepatocytes growing in a fibrous environment.
(17) Friend erythroleukemia cells were induced to differentiate by dimethyl sulfoxide (DMSO) and hexamethylene-bis-acetamide (HBMA) in order to investigate whether their lipid characteristics, common to other systems of transformed cells, revert to a normal differentiation pattern.
(18) By growing purified human cytotrophoblasts under serum-free conditions and manipulating the culture surface, we were able to disassociate morphologic from biochemical differentiation.
(19) Therefore, the measurement of the alpha-antitrypsin content plays the crucial part in differential diagnosis of primary (hereditary determined) and secondary (obstructive) emphysema.
(20) Although each of palate and limb is concurrently susceptible to epigenetic regulation, their differential intrinsic genomic capabilities appear to have been uncoupled.
Undifferentiated
Definition:
(a.) Not differentiated; specifically (Biol.), homogenous, or nearly so; -- said especially of young or embryonic tissues which have not yet undergone differentiation (see Differentiation, 3), that is, which show no visible separation into their different structural parts.
Example Sentences:
(1) The subcellular distribution of sialyltransferase and its product of action, sialic acid, was investigated in the undifferentiated cells of the rat intestinal crypts and compared with the pattern observed in the differentiated cells present in the surface epithelium.
(2) Macrophages, undifferentiated fibroblasts and highly differentiated fibroblasts can be observed.
(3) Carcinomas exhibiting atypical behavior are characteristically undifferentiated and aggressive.
(4) Because of its potential significance in human lung cancer, we investigated the expression of the CYP1A1 structural gene in 24 established human lung cancer cell lines including 15 non-small cell (eight adenocarcinomas, three large cell undifferentiated carcinomas, two bronchioloalveolar cell carcinomas, and two squamous cell carcinomas) and nine small cell lung carcinomas.
(5) All 51 undifferentiated NPCs contained significant numbers of EBV-genome copies per cell.
(6) Unfortunately, it does not contain a population of undifferentiated stem cells to supply the necessary healthy neurons.
(7) The anterior division can be further parcellated into dorsal, lateral, and ventral areas, and each of these areas, along with the posterior division, can be thought of as containing more-or-less discrete nuclei embedded within a relatively undifferentiated region.
(8) In undifferentiated glioblastomas, the reverse situation was observed, no SS receptors were found (0 of 14) but EGF receptors were present in a majority of tumors (8 of 14).
(9) The human epidermal growth factor receptor (hEGF-R) was introduced into murine P19 embryonal carcinoma (EC) cells, which do not express endogenous EGF-R. Undifferentiated stable P19 EC transfectants containing multiple copies of the hEGF-R complementary DNA were isolated.
(10) However, the tip cells are slow to differentiate, and hence immature fruiting bodies contain a small population of undifferentiated tip cells.
(11) We report on a patient with AL, which showed a very rapid switch from the lymphoblastic phenotype exhibited at presentation to a myelomonoblastic one, appeared at first relapse, and lastly progressed to an undifferentiated leukemia in the terminal phase.
(12) The pathologic diagnosis was rhabdomyosarcoma in 75% of cases, yolk sac tumor in 13% of cases, malignant mesenchymoma in two cases, clear cell carcinoma in two cases, and undifferentiated sarcoma in one case.
(13) Of 28 rats given 0.15 mg of 1,6-DNP, 21 (75%) developed squamous cell carcinomas, 2 (7%) developed undifferentiated carcinomas, and 2 (7%) had squamous metaplasias in the lung by 72 weeks.
(14) A case of large cell undifferentiated adenocarcinoma of the lung was complicated by an aggressive clinical course and documented placental metastases.
(15) In anurans, the oculomotor neurons receive a variety of visual, somatic, and vestibular afferents and appear relatively undifferentiated, whereas the nInt appears more developed.
(16) In previous specimens, solid undifferentiated carcinoma was absent or was a minor pattern.
(17) There was a nonsignificant trend toward higher MHPG levels in paranoid schizophrenic patients in comparison with patients who had undifferentiated schizophrenia.
(18) The process from the first undifferentiated stage to the second predifferentiated stage with well-developed ER and Golgi apparatus requires both collagen gels and hormones.
(19) The possibility of preventing or influencing the course of these diseases by vaccination has been advocated for a number of years [Epstein, 1976], especially in the case of undifferentiated nasopharyngeal carcinoma, which is the most common tumour of men in southern China and is prevalent in other specific regions; it therefore represents a major world cancer problem [Shanmugaratnam, 1971].
(20) Ultrastructurally, the tumor cells were composed principally of undifferentiated mesenchymal cells, and contained prominent pools of glycogen in the cytoplasm.