What's the difference between differentiation and epigenesis?

Differentiation


Definition:

  • (n.) The act of differentiating.
  • (n.) The act of distinguishing or describing a thing, by giving its different, or specific difference; exact definition or determination.
  • (n.) The gradual formation or production of organs or parts by a process of evolution or development, as when the seed develops the root and the stem, the initial stem develops the leaf, branches, and flower buds; or in animal life, when the germ evolves the digestive and other organs and members, or when the animals as they advance in organization acquire special organs for specific purposes.
  • (n.) The supposed act or tendency in being of every kind, whether organic or inorganic, to assume or produce a more complex structure or functions.

Example Sentences:

  • (1) AEDs may also have differential effects on nighttime sleep.
  • (2) We used the polymerase chain reaction (PCR) to amplify the breakpoint area of alpha-thalassemia-1 of Southeast Asia type and several parts of the alpha-globin gene cluster to make a differential diagnosis between alpha-thalassemia-1 and Hb Bart's hydrops fetalis.
  • (3) We also show that proliferation of primary amnion cells is not dependent on a high c-fos expression, suggesting that the function of c-fos is more likely to be associated with other cellular functions in the differentiated amnion cell.
  • (4) The subcellular distribution of sialyltransferase and its product of action, sialic acid, was investigated in the undifferentiated cells of the rat intestinal crypts and compared with the pattern observed in the differentiated cells present in the surface epithelium.
  • (5) We have investigated the increase in the spcDNA population upon cycloheximide treatment of individual sequences, which are found to amplify differentially.
  • (6) Periosteal chondroma is an uncommon benign cartilagenous lesion, and its importance lies primarily in its characteristic radiographic and pathologic appearance which should be of assistance in the differential diagnosis of eccentric lesions of bones.
  • (7) The differential diagnosis is more complex in Hawaii due to the presence of granulomatous diseases such as tuberculosis and leprosy.
  • (8) At 48 h after pretreatment, a differential effect on the absorption of sulfanilamide and L-tryptophan was observed in in situ recirculation experiments.
  • (9) The results suggest differential regulation of IL-6 expression between fibroblasts and macrophages.
  • (10) Differentiation between these two types of lesions is of utmost importance since the surgical approach will be different.
  • (11) The following conclusions emerge: (i) when the 3' or the 3' penultimate base of the oligonucleotide mismatched an allele, no amplification product could be detected; (ii) when the mismatches were 3 and 4 bases from the 3' end of the primer, differential amplification was still observed, but only at certain concentrations of magnesium chloride; (iii) the mismatched allele can be detected in the presence of a 40-fold excess of the matched allele; (iv) primers as short as 13 nucleotides were effective; and (v) the specificity of the amplification could be overwhelmed by greatly increasing the concentration of target DNA.
  • (12) Dibutyryl cyclic AMP (dbcAMP) treatment of Neuro 2A neuroblastoma cells induces cell differentiation and neurite outgrowth.
  • (13) This experimental system allows separation of three B lymphocyte developmental stages: early differentiation in vitro, progression to IgM secretion in vivo, and late differentiation dependent upon mature T lymphocytes in vivo.
  • (14) A murine keratinocyte cell line that is resistant to the growth-inhibitory effects of transforming growth factor beta 1 (TGF beta 1) was examined for differential gene expression patterns that may be related to the mechanism of the loss of TGF beta 1 responsiveness.
  • (15) SD is shown to have therapeutic and differential diagnostic significance in varying pathological conditions of cerebral dopaminergic systems.
  • (16) Aside from these characteristic findings of HCC, it was important to reveal the following features for the diagnosis of well differentiated type of small HCC: variable thickening or distortion of trabecular structure in association with nuclear crowding, acinar formation, selective cytoplasmic accumulation of Mallory bodies, nuclear abnormalities consisting of thickening of nucleolus, hepatic cords in close contact with bile ducts or blood vessels, and hepatocytes growing in a fibrous environment.
  • (17) Friend erythroleukemia cells were induced to differentiate by dimethyl sulfoxide (DMSO) and hexamethylene-bis-acetamide (HBMA) in order to investigate whether their lipid characteristics, common to other systems of transformed cells, revert to a normal differentiation pattern.
  • (18) By growing purified human cytotrophoblasts under serum-free conditions and manipulating the culture surface, we were able to disassociate morphologic from biochemical differentiation.
  • (19) Therefore, the measurement of the alpha-antitrypsin content plays the crucial part in differential diagnosis of primary (hereditary determined) and secondary (obstructive) emphysema.
  • (20) Although each of palate and limb is concurrently susceptible to epigenetic regulation, their differential intrinsic genomic capabilities appear to have been uncoupled.

Epigenesis


Definition:

  • (n.) The theory of generation which holds that the germ is created entirely new, not merely expanded, by the procreative power of the parents. It is opposed to the theory of evolution, also to syngenesis.

Example Sentences:

  • (1) Here, however, it is shown that a more general version of epigenesis can be held, because of a new principle which states that it is mathematically possible to obtain not only a convergent generation of form, or structure, but also a convergent generation of information.
  • (2) The study suggests that various second-trimester prenatal disturbances in the epigenesis of one twin in a pair discordant for schizophrenia may be related to the fact that only one of the twins expresses his or her genetic predisposition toward schizophrenia.
  • (3) A quantitative re-examination was made of the influence of noradrenergic depletion on the epigenesis of kitten visual cortex.
  • (4) This, the first linear morphometric analysis of the epigenesis of the fetal mammalian adrenal cortex, has shown that in the fetal sheep during the latter two thirds of gestation and in the newborn lamb, there are two periods of rapid growth separated by a period of much reduced growth.
  • (5) The epigenesis of the different muscles is related to the appearance of their various functions.
  • (6) Two sequential stages occur: 1) the realisation of an intrinsic programme of maturation, by which cortical specificity appears at eye opening and increases independently of visual experience 2) a phase of "epigenesis" beginning at 19 days, during which functional modification depends on visual experience.
  • (7) It has been observed that the activity of acid phosphatase does not remain constant, but undergoes changes at different phases of epigenesis.
  • (8) We report here that functional changes in single neurons of area 17, analogous to those known to take place during epigenesis of visual cortex, can be induced experimentally during the time of recording.
  • (9) Next, epigenetic influences on synaptogenesis are examined, and later in the article the concept of epigenesis is integrated with that of hierarchy.
  • (10) A mathematical modeling approach called epigenesis theory is presented which relates three aspects of pathogenesis to the population distribution of disease.
  • (11) The activity rhythmically becomes higher and lower throughout the whole period of epigenesis.
  • (12) Both specific epigenesis and specific cell kinetics are involved.
  • (13) The theory of epigenesis is the undisputed paradigm of embryology, and it is still based on the classical concept proposed by Aristotle: the idea that embryonic development is a generation of structures which takes place according to a design--today we say a set of instructions--already present in the fertilized egg.
  • (14) Epigenesis theory unifies the sufficient-component causes model and the simple independent action model and exceeds either model in the range of observations it can explain.
  • (15) Epigenesis theory defines the following multivariable relations between two disease causes: 1) "Complementary" causes contribute different causal actions to the sole pathogenic process leading to disease.
  • (16) Models of disease causation pertinent to IDDM are presented with a primary focus on the recently developed epigenesis theory.