(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.
Effort
Definition:
(n.) An exertion of strength or power, whether physical or mental, in performing an act or aiming at an object; more or less strenuous endeavor; struggle directed to the accomplishment of an object; as, an effort to scale a wall.
(n.) A force acting on a body in the direction of its motion.
(v. t.) To stimulate.
Example Sentences:
(1) An effective graft-surveillance protocol needs to be applicable to all patients; practical in terms of time, effort, and cost; reliable; and able to detect, grade, and assess progression of lesions.
(2) Recently, the validity of the American Thoracic Society (ATS) standards for selection of spirometric test results has been questioned based on the finding of inverse dependence of FEV1 on effort.
(3) Research efforts in the Swedish schools are of high quality and are remarkably prolific.
(4) Several efforts to extradite Polanski to California have failed.
(5) Another important factor, however, seems to be that patients, their families, doctors and employers estimate capacity of performance on account of the specific illness, thus calling for intensified efforts toward rehabilitation.
(6) King Salman of Saudi Arabia urged the redoubling of efforts to “eradicate this dangerous scourge and rid the world of its evils”.
(7) Their efforts will include blocking the NSA from undermining encryption and barring other law enforcement agencies from collecting US data in bulk.
(8) In light of these findings, the implications of the need to address appraisals and coping efforts in research and therapy with incest victims was emphasized.
(9) Mastitis in its complexity has managed to forestall all efforts of eradication in spite of years of research, antibiotics and practical control measures.
(10) Crown prince Sultan Bin Abdel Aziz said yesterday that the state had "spared no effort" to avoid such disasters but added that "it cannot stop what God has preordained.
(11) In our efforts to explore alternative treatment regimens for multidrug-resistant tumors we have examined the sensitivity of MDR tumor cell lines to lymphokine activated killer (LAK) cells.
(12) This will help nursing grow as a profession, particularly through entrepreneurial and intrapreneurial efforts.
(13) However, our theory differs in several important respects from the latter efforts.
(14) The results of our utilization review were conveyed to local hospitals and the blood supplier in an effort to preserved donor blood.
(15) In an effort to understand the regulation of the onset of testosterone formation in the human fetal testis we measured adenylate cyclase activity in response to hCG stimulation in homogenates of fetal testes obtained from first and second trimester human abortuses.
(16) In addition, special efforts are made to combine HIV-infected women to avoid pregnancy and childbearing, both for their own prognosis and the health of the infant.
(17) In an effort to identify the optimal dose and strain of measles vaccination for early immunization, Peruvian infants were randomly assigned to receive one of three measles vaccines in varying doses at 5 to 6 or 8 to 9 months of age.
(18) Abe’s longstanding efforts toward those goals, which include the successful passage of a state secrets act and efforts to expand the scope of Japan’s military activities have already damaged relations with China.
(19) Chadwick felt that Customs and Trading Standards needed to continue their war on illegal tobacco – if not, efforts to tackle smoking could be undermined.
(20) "We must be clear that there can be no letup in our efforts to seek ways to remove Bill Walker from parliament," Rennie said.