(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.
Extreme
Definition:
(a.) At the utmost point, edge, or border; outermost; utmost; farthest; most remote; at the widest limit.
(a.) Last; final; conclusive; -- said of time; as, the extreme hour of life.
(a.) The best of worst; most urgent; greatest; highest; immoderate; excessive; most violent; as, an extreme case; extreme folly.
(a.) Radical; ultra; as, extreme opinions.
(a.) Extended or contracted as much as possible; -- said of intervals; as, an extreme sharp second; an extreme flat forth.
(n.) The utmost point or verge; that part which terminates a body; extremity.
(n.) Utmost limit or degree that is supposable or tolerable; hence, furthest degree; any undue departure from the mean; -- often in the plural: things at an extreme distance from each other, the most widely different states, etc.; as, extremes of heat and cold, of virtue and vice; extremes meet.
(n.) An extreme state or condition; hence, calamity, danger, distress, etc.
(n.) Either of the extreme terms of a syllogism, the middle term being interposed between them.
(n.) The first or the last term of a proportion or series.
Example Sentences:
(1) In this study of ten consecutive patients sustaining molten metal injuries to the lower extremity who were treated with excision and grafting, treatment with compression Unna paste boot was compared with that with conventional dressing.
(2) But Lee is mostly just extremely fed up at the exclusion of sex workers’ voices from much of the conversation.
(3) The extreme quenching of the dioxetane chemiluminescence by both microsomes and phosphatidylcholine, as a model phospholipid, implies that despite the low quantum yield (approx.
(4) The results show that endolymph is extremely inhomogenous with respect to calcium potentials.
(5) Even so, amputation of fifteen extremities and four other major excisions were required in twelve patients.
(6) I hope this movement will continue and spread for it has within itself the power to stand up to fascism, be victorious in the face of extremism and say no to oppressive political powers everywhere.” Appearing via videolink from Tehran, and joined by London mayor Sadiq Khan and Palme d’Or winner Mike Leigh, Farhadi said: “We are all citizens of the world and I will endeavour to protect and spread this unity.” The London screening of The Salesman on Sunday evening wasintended to be a show of unity and strength against Trump’s travel ban, which attempted to block arrivals in the US from seven predominantly Muslim countries: Iran, Iraq, Libya, Sudan, Somalia, Syria and Yemen.
(7) He had been extremely frustrated that indicators of economic recovery over the past few days had been drowned out by the clamour over the Labour leadership.
(8) Poor lipophilicity and extremely low plasma concentrations impose severe constraints.
(9) This suggests that molars do not maintain a fixed relationship to incisors over time, and extreme care must be taken to standardize an experiment to a specific body weight when using this method.
(10) Eighty-four paraplegic patients whose injury level was T2 or below and who were at least one year from spinal cord injury were screened for upper extremity complaints.
(11) A retrospective review was undertaken of 127 lower extremity fasciotomies performed for compartment syndrome after acute ischemia and revascularization in 73 patients with vascular trauma and 49 patients with arterial occlusive disease.
(12) TNBS reacts to an extremely small extend with hemoglobin over the concentration range 0.4 to 4 mM whereas FDNB reacts with hemoglobin to a very large extent (50 fold more than TNBS).
(13) While the reduced form of the "derived" polyphenolic compounds, generated during tissue homogenization, appeared to enhance dye binding with bovine serum albumin, their influence on the protein assay directly in crude homogenates was extremely diverse.
(14) Although statistical analysis did not show dramatic changes in all these parameters, some individual extreme values were substantially altered.
(15) Survival and healing of "extremely severe" grade intoxication can only be obtained through a surgical intervention within the first hours; a laparotomy will indicate the depth of the lesions, which is not determined by endoscopy, and will consist of Celerier's stripping method and if necessary a gastrectomy, more seldom a cephalic duodeno-pancreatectomy.
(16) In the absence of haemodialysis, the decline in plasma concentrations of lisinopril and enalaprilat was extremely slow and plasma concentrations were generally high.
(17) The authors recently observed 2 elderly female patients with ischemic pain of the upper extremity as the first manifestation of giant cell arteritis.
(18) In the process, the DfE's definition of extremism has shifted from actual bomb-throwers to religious conservatives.
(19) Accordingly, LPA proved an extremely stable characteristic which did not show any substantial variations in the course of five years.
(20) Formation of the functional contour plaster bandage within the limits of the foot along the border of the fissure of the ankle joint with preservation of the contours of the ankles 4-8 weeks after the treatment was started in accordance with the severity of the fractures of the ankles in 95 patients both without (6) and with (89) dislocation of the bone fragments allowed to achieve the bone consolidation of the ankle fragments with recovery of the supportive ability of the extremity in 85 (89.5%) of the patients, after 6-8 weeks (7.2%) in the patients without displacement and after 10-13 weeks (11.3%) with displacement of the bone fragments of the ankles.