(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.
Insoluble
Definition:
(a.) Not soluble; in capable or difficult of being dissolved, as by a liquid; as, chalk is insoluble in water.
(a.) Not to be solved or explained; insolvable; as, an insoluble doubt, question, or difficulty.
(a.) Strong.
Example Sentences:
(1) The samples are first disrupted by sonication and the insoluble proteins concentrated by high-speed centrifugation.
(2) The relationship between cold-insoluble complexes, or cryoglobulins, and renal disease was studied in rabbits with acute serum sickness produced with BSA.
(3) One cellulase is buffer-soluble, the other buffer-insoluble but extractable with high salt concentrations.
(4) Evidence is presented which suggests that these plasmid-mediated, temperature-inducible surface fibrillae are responsible for autoagglutination and are related to production of one prominent, Sarkosyl-insoluble polypeptide of ca.
(5) During the growth of Azotobacter vinelandii in batch culture in Burk's 2% glucose medium supplemented with 50 mg EDTA per litre, water-insoluble capsular polysaccaride material accumulated in cultures prior to the appearance of water-soluble polysaccharide in the culture medium.
(6) A Nonidet P 40 insoluble fraction was isolated from Trypanosoma brucei and was used to raise a monoclonal antibody (5E9).
(7) Insoluble collagen was found to bind electrostatically to chondromucoprotein.
(8) After 6 weeks irradiation, the insoluble collagen and elastin were both substantially elevated, as were the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD).
(9) However, since the Krafft point of lincomycin palmitate is approximately 43 degrees, it does not form micelles below that temperature and appears to be quite insoluble until heated above 43 degrees.
(10) Average remnant diameters were 400-600 A and remnants were enriched in cholesteryl esters and in protein insoluble in tetramethylurea.
(11) Ultrastructural studies of detergent-insoluble cytoskeletons from infected cells and immunofluorescence microscopy of phalloidin-labeled cells showed alterations in the structure of the cytoskeleton during the internalization process including the accumulation of polymerized actin around entering bacteria.
(12) Cells obtained from 12-day tissue remained monolayers for 4 to 8 days, after which time portions of the culture contracted into matrix containing chemically definable insoluble elastin and forming desmosine cross-links.
(13) Micrococcal nuclease-digested testis and erythrocyte chromatin was separated into soluble and insoluble fractions.
(14) Five other patients with water-insoluble paraproteins were tested; two were clot-inhibitory.
(15) Both main-stream and side-stream cigarette smoke condensates and some fractions, containing water-soluble bases, water-insoluble bases, and polycyclic aromatic hydrocarbons, were found to induce AHH activity in lung and liver, the lung being induced to the greatest extent.
(16) The protein component was relatively insoluble and contained an excess of acidic over basic amino acids and little cystine.
(17) Biochemical analysis of the kinetics of assembly of two cytoplasmic plaque proteins of the desmosome, desmoplakins I (250,000 Mr) and II (215,000 Mr), in Madin-Darby canine kidney (MDCK) epithelial cells, demonstrated that these proteins exist in a soluble and insoluble pool, as defined by their extract ability in a Triton X-100 high salt buffer (CSK buffer).
(18) The ratio of soluble to insoluble beta-galactosidase decreased during the course of cell growth.
(19) GP Ib was sedimented with the Triton-insoluble actin filaments in trace amounts only, and only after high speed centrifugation (100,000 x g, 3 h).
(20) Elastic fibers have been shown to contain two proteins, insoluble elastin and the elastic fiber microfibril, a glycoprotein.