(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.
Narrow
Definition:
(superl.) Of little breadth; not wide or broad; having little distance from side to side; as, a narrow board; a narrow street; a narrow hem.
(superl.) Of little extent; very limited; circumscribed.
(superl.) Having but a little margin; having barely sufficient space, time, or number, etc.; close; near; -- with special reference to some peril or misfortune; as, a narrow shot; a narrow escape; a narrow majority.
(superl.) Limited as to means; straitened; pinching; as, narrow circumstances.
(superl.) Contracted; of limited scope; illiberal; bigoted; as, a narrow mind; narrow views.
(superl.) Scrutinizing in detail; close; accurate; exact.
(superl.) Formed (as a vowel) by a close position of some part of the tongue in relation to the palate; or (according to Bell) by a tense condition of the pharynx; -- distinguished from wide; as e (eve) and / (f/d), etc., from i (ill) and / (f/t), etc. See Guide to Pronunciation, / 13.
(n.) A narrow passage; esp., a contracted part of a stream, lake, or sea; a strait connecting two bodies of water; -- usually in the plural; as, The Narrows of New York harbor.
(v. t.) To lessen the breadth of; to contract; to draw into a smaller compass; to reduce the width or extent of.
(v. t.) To contract the reach or sphere of; to make less liberal or more selfish; to limit; to confine; to restrict; as, to narrow one's views or knowledge; to narrow a question in discussion.
(v. t.) To contract the size of, as a stocking, by taking two stitches into one.
(v. i.) To become less broad; to contract; to become narrower; as, the sea narrows into a strait.
(v. i.) Not to step out enough to the one hand or the other; as, a horse narrows.
(v. i.) To contract the size of a stocking or other knit article, by taking two stitches into one.
Example Sentences:
(1) The PSB dioxygenase system displayed a narrow substrate range: none of 18 sulphonated or non-sulphonated analogues of PSB showed significant substrate-dependent O2 uptake.
(2) Comparison of developmental series of D. merriami and T. bottae revealed that the decline of the artery in the latter species is preceded by a greater degree of arterial coarctation, or narrowing, as it passes though the developing stapes.
(3) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(4) In all immunized rabbits the antisera obtained with the 7 alpha-derivative had a higher affinity and a narrower specificity than the antiserum obtained with the 7 beta-derivative.
(5) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(6) Photograph: AP Reasons for wavering • State relies on coal-fired electricity • Poor prospects for wind power • Conservative Democrat • Represents conservative district in conservative state and was elected on narrow margins Campaign support from fossil fuel interests in 2008 • $93,743 G K Butterfield (North Carolina) GK Butterfield, North Carolina.
(7) Their narrowed processes pass at a common site through the muscle layer and above this layer again slightly widen and project above the neighbouring tegument.
(8) These patients did not have narrow anterior chamber angles preoperatively, and several were aphakix with surgical iris colobomas.
(9) The linewidths of the methionine Cepsilon resonances are narrowed by increasing temperature according to an Arrhenius energy of activation of nearly 3 kcal.
(10) The detergent lauryl maltoside abolishes respiratory control and proton ejection by cytochrome c oxidase-containing proteoliposomes over a narrow concentration range.
(11) Per-rotational nystagmus was recorded in rabbits with unilaterally narrowed vertebral arteries or following unilateral cervical sympathectomies.
(12) However, the narrow range of the ED50 suggests relatively little variation in the response of the different isolates in vivo and similarly small variation was also noted in some of the tests in vitro.
(13) Eight patients had glaucoma only in one eye; three narrow-angle glaucoma, three primary open-angle glaucoma and two secondary glaucoma.
(14) In the fifth case the vein was too narrow to allow catheterization.
(15) It was found that within the dorsal part of the well known pressor area there is a narrow strip, 2.5 mm lateral from the mid line, starting ventral to the inferior colliculus and ending in the medulla close to the floor of the IV ventricle, from which vasodilatation in skeletal muscles is selectively obtained.
(16) Each border was within a region of 11 nucleotides and gave rise to a narrow size range (1248-1261 nucleotides) for the population of 22 subgenomic DNAs.
(17) These factors include narrowing of septal arteries and the artery to the atrioventricular node, preservation of fetal anatomy with dispersion in the atrioventricular node and His bundle, fibrosis of the sinus node, clefts in the septum, multiple atrioventricular pathways and massive myocardial infarction.
(18) Time suggests that the FBI inquiry has been extended from a relatively narrow look at alleged malpractices by News Corp in America into a more general inquiry into whether the company used possibly illegal strongarm tactics to browbeat rival firms, following allegations of computer hacking made by retail advertising company Floorgraphics.
(19) These three activities, appearing within a narrow range of molecular weights, different from those of other known lymphokines, suggest the existence of a distinct class of lymphokine mediators with the common function of influencing functional properties of tumor cells.
(20) The narrow intercellular ridge is smooth, whereas the epithelial cells have small cytoplasmic knobs between the cilia.