(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.
Spiny
Definition:
(a.) Full of spines; thorny; as, a spiny tree.
(a.) Like a spine in shape; slender.
(a.) Fig.: Abounding with difficulties or annoyances.
(n.) See Spinny.
Example Sentences:
(1) These results suggest that: (1) catecholaminergic (mainly dopaminergic) and prefrontal cortical terminals in the nucleus accumbens septi dually synapse on common spiny neurons; and (2) dopaminergic neurons in the ventral tegmental area receive monosynaptic input from prefrontal cortical afferents.
(2) The responses of a population of 30 olfactory receptor cells from spiny lobsters to 8 behaviorally relevant complex types of stimuli at 0.005, 0.05 and 0.5 mM were analyzed using multidimensional scaling to evaluate their potential for coding quality and intensity.
(3) Extracellular responses to complex biologically relevant stimuli were recorded from 30 primary olfactory cells from excised antennules of spiny lobsters.
(4) Earlier studies identified purinergic chemoreceptors in the olfactory organ of the spiny lobster, Panulirus argus.
(5) We speculate that in the adult neostriatum, the protein may be important in the remodeling of synapses onto medium spiny neurons that involve, in part, the corticostriatal pathway.
(6) Tissue from the digitiform rectal gland of the spiny dogfish, Squalus acanthias, was fixed briefly by formaldehyde perfusion and studied for the specificity and localization of p-nitrophenyl phosphatase (NPP'ase) activity.
(7) Type 2 multipolar cells are large neurons endowed with numerous primary spiny dendrites constituting a wide round dendritic field and with a thick axon.
(8) Spiny seahorse lives among a rare marine plant called eelgrass, which only grows in shallow sheltered seas in south-west England.
(9) The axon of the spiny type II neuron is long and has collaterals which are poorly arborized in comparison to those of spiny type I cells.
(10) Neurons of medium size with spine-rich dendrites (spiny type I) are the most frequent type.
(11) When taken together these cases show that just over 50% of the degenerating terminals are presynaptic to spiny appendages and are located within the synaptic clusters (glomeruli) described previously (King, '76).
(12) The external surface of the hypostome possesses cnidocils, possibly sensory hairs, and small spiny protrusions surrounding the mouth; the internal surface has cylindrical microvilli, free flagella and adherent flagella.
(13) Finally, they are at variance with the classical concept which subdivides cortical neurons into projection neurons (pyramidal and spiny stellate) and interneurons (non-pyramidal, local circuit neurons).
(14) Leishmania braziliensis panamensis has been isolated in culture from one spiny-pocket mouse (Heteromys dermarestianus) out of 43 examined, proving that rodents of this genus can be reservoirs of Leishmania of the braziliensis complex as well as of mexicana in Latin America.
(15) Several types of NPY-containing neurons can be distinguished by their laminar location, by the size of their perikarya, and by the size, shape, and pattern of ramification of their processes: 1) layer I small local circuit neurons; 2) layer II granule cells; 3) aspiny stellate cells located in layers II-III and V-VI, with long, slender dendrites; 4) sparsely spiny stellate cells; 5) aspiny stellate cells with long, horizontally oriented dendrites, whose cell body is situated in layer VI; 6) Martinotti cells in areas 9, 7, and 24; and 7) multipolar neurons situated in the white matter subjacent to the cortical gray.
(16) The naturally occurring dynamics of presynaptic axon terminals were investigated in the dentate gyrus and stratum lucidum of the spiny mouse (Acomys cahirinus) during maturation, adulthood and aging.
(17) Light and electron microscopy showed intense and extensive labeling of immunoreactive calbindin-D28k in the cell bodies, dendrites, and spines of medium-sized neostriatal spiny neurons and in their axon terminals which end in the globus pallidus.
(18) The SFGS was seen to contain pyramidal neurons with spiny dendrites in the SM, together with fusiform, multipolar and horizontal neurons.
(19) Spiny extrusions are present on many of the neurons, arranged either as varicosities giving a rosary feature or clumped in small groups over the dendritic processes; these are absent at the level of the soma.
(20) This is a report of experiments which provide evidence in support of the existence of an electric sense in the echidna, or spiny anteater Tachyglossus aculeatus.