(a.) Hard to do or to make; beset with difficulty; attended with labor, trouble, or pains; not easy; arduous.
(a.) Hard to manage or to please; not easily wrought upon; austere; stubborn; as, a difficult person.
(v. t.) To render difficult; to impede; to perplex.
Example Sentences:
(1) Virtually every developed country has some form of property tax, so the idea that valuing residential property is uniquely difficult, or that it would be widely evaded, is nonsense.
(2) Although solely nociresponsive neurons are clearly likely to fill a role in the processing and signalling of pain in the conscious central nervous system, the way in which such useful specificity could be conveyed by multireceptive neurons is difficult to appreciate.
(3) In practice, however, the necessary dosage is difficult to predict.
(4) Cor triatriatum (CT) is a rare congenital defect, surgically correctable, and sometimes difficult to diagnose by cardiac catheterization.
(5) By drawing from the pathophysiology, this article discusses a multidimensional approach to the treatment of these difficult patients.
(6) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(7) The way we are going to pay for that is by making the rules the same for people who go into care homes as for people who get care at their home, and by means-testing the winter fuel payment, which currently isn’t.” Hunt said the plan showed the Conservatives were capable of making difficult choices.
(8) In many cases, physicians seek to protect themselves from involvement with these difficult, highly anxious patients by making a referral to a psychiatrist.
(9) The diagnosis of variant- or Prizmetal-angina is difficult because if insufficient specificity of the tests.
(10) The detection of these antibodies is difficult owing to the lack of standardization and of specificity of the laboratory tests.
(11) It was so difficult to keep a straight face when I was filming a sauna scene with Roy Barraclough, who played the mayor of Blackpool.
(12) That is, he believes, to look at massively difficult, interlocking problems through too narrow a lens.
(13) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(14) If they end up going to another club that is difficult to take.
(15) Cigarette consumption has also been greater in urban areas, but it is difficult to estimate how much of the excess it can account for.
(16) The most difficult thing I've dealt with at work is ... the terminal illness of a valued colleague.
(17) In that respect, it's difficult to see Allen's anthem as little more than same old same old, and it's probably why I ultimately feel she misses the mark.
(18) This hypothesis is difficult to substantiate with direct measurements using human subjects.
(19) Extrapolation of gestational age from early crown-rump lengths (CRLs) has been difficult because previously established tables of CRL versus gestational age have contained few measurements at less than seven to eight weeks from the first day of the last menses.
(20) Companies had made investments in certain energy sources, the president said, so change could be “uncomfortable and difficult”.
Uphill
Definition:
(adv.) Upwards on, or as on, a hillside; as, to walk uphill.
(a.) Ascending; going up; as, an uphill road.
(a.) Attended with labor; difficult; as, uphill work.
Example Sentences:
(1) Distance running performance is slower on hilly race courses than flat courses even when the start and finish are at the same elevation, resulting in equal amounts of uphill and downhill running.
(2) Gillard faces an uphill battle convincing the electorate to back her.
(3) Like the parental strain, all three types of triple mutant showed moderate rates of downhill lactose transport and were defective in the uphill accumulation of sugars.
(4) The ascorbate oxidation was coupled to the uphill Na+ extrusion which was stimulated by CCCP and a penetrating weak base, diethylamine, as well as by valinomycin with or without diethylamine.
(5) Physiological strain was greater in uphill than in level or downhill walking (P less than .001).
(6) Senator Davis is a strong, viable, credible candidate who has raised a substantial amount of money and is the best candidate for Democrats – but it’s still an uphill battle,” he said.
(7) These results indicate that body posture can affect energy expenditure during uphill bicycling through factors unrelated to air resistance.
(8) It functions as a pair of easy-to-use skis for walking uphill, then when it’s time to head down, it quickly transforms into a toboggan for riding safely and enjoyably back to the resort, perhaps even with a few powder turns along the way.
(9) Speaking to the Guardian, Rotheram acknowledged the party faced an uphill struggle in a campaign the Tories are framing as a personality contest between party leaders.
(10) Stonewall does great work but the gay campaign for marriage equality faced an uphill struggle, which was made worse by Stonewall constantly undermining our efforts.
(11) It's going to be uphill for LA here - New York should be thinking: "No stupid penalties, no stupid penalties..." and repeat.
(12) As the transport of cefaclor showed no uphill uptake in the presence of a H+ gradient and its H+ stimulated uptake was small, a H+ gradient-independent carrier-mediated system seems to participate in its transport.
(13) The post-trial injection of 1 ng SP (in 0.5 microliter volume) led to significantly longer latencies in the uphill response.
(14) These are our treaty lands, and we need to protect clean water.’ Photograph: Sam Levin for the Guardian In a recent interview, Archambault acknowledged that the tribes face an uphill battle in the US judicial system: “We always knew that the federal court system was against Indian country.
(15) Heart rate and skiing velocities were analyzed over a flat, an uphill, and a downhill section, as well as for the total loop.
(16) Although efforts to win over Republican hawks appear close to gaining sufficient support in the Senate, the White House continues to face an uphill struggle to persuade enough members of Congress from both parties to authorise its planned strike against Syria in the House.
(17) We have a lot to do in the run up to 2020 – there’s a long road ahead of us and it will be an uphill struggle, but if we can mobilise more people, young and old, and continue to provide a real alternative to austerity and Obsornomics, we might just be in with a fighting chance.
(18) Dyspnoea grade 1 (shortness of breath when walking quickly on the level or uphill) was less well related to age.
(19) Transport of L-glutamic acid into the fission yeast Schizosaccharomyces pombe grown to the early stationary phase and preincubated for 60 min with 1% D-glucose is practically unidirectional and is mediated by a single uphill transport system with a KT of 170 microM and Jmax of 4.8 nmol min-1 (mg dry wt.)-1.
(20) It has been possible to form vesicles from the purified enzyme from Squalus acanthias and to demonstrate the ATP-dependent, ouabain inhibitable, coupled uphill transports of Na+ and K+.