(n.) The state of being difficult, or hard to do; hardness; arduousness; -- opposed to easiness or facility; as, the difficulty of a task or enterprise; a work of difficulty.
(n.) Something difficult; a thing hard to do or to understand; that which occasions labor or perplexity, and requires skill and perseverance to overcome, solve, or achieve; a hard enterprise; an obstacle; an impediment; as, the difficulties of a science; difficulties in theology.
(n.) A controversy; a falling out; a disagreement; an objection; a cavil.
(n.) Embarrassment of affairs, especially financial affairs; -- usually in the plural; as, to be in difficulties.
Example Sentences:
(1) Technical factors that account for increased difficulty in these patients include: problems with guide catheter impaction and ostial trauma; inability to inflate the balloon with adequate guide catheter support; and need for increased intracoronary manipulation.
(2) To overcome this difficulty, a "hetero-antibody" RIA was studied.
(3) Epidemiological studies on low risks involve a number of major methodological difficulties.
(4) Mild swallowing difficulties occurred in 18 patients (39%), moderate dysfunction in 23 (50%), and severe dysfunction in five (11%).
(5) Reasons for non-acceptance do not indicate any major difficulties in the employment of such staff in general practice, at least as far as the patients are concerned.
(6) Spontaneous reports of suspected adverse reactions may be the only way of revealing very rare events but they present great difficulties of rational interpretation.
(7) The indication of the DNA probe method would be considered in the four cases as follows, 1. necessity of the special equipment to isolate the pathogen, 2. necessity of the long period to isolate the pathogen, 3. existence of the cross reaction among the pathogen and relative organisms in the immunological procedure, 4. existence of the difficulty to identify the species of the pathogen by the ordinary procedure.
(8) The 1-0-methylalduronic-acidmethylesters, obtained by the methanolysis of the polysaccharides, are reduced with boronhydrid to the corresponding methyl glycosides; there are split with acid to the aldoses, which are converted in pyridine with hydroxylamine to the aldoximes and than with acetic anhydride to the aldonitrilacetates, which can be separated by gaschromatography without difficulty.
(9) A control experiment demonstrated that changes in general arousal could not account for the effects of task difficulty on neuronal responses.
(10) In the anatomy laboratory we looked for an alternative approach to the glenohumeral joint which would accommodate these difficulties.
(11) A 27-year-old lady presented with history of discomfort in the throat and difficulty in swallowing for two weeks.
(12) Especially in the old patients (over 70 years) the incisional hernias represents an invalidating pathology whose treatment, for the high incidence of associated diseases of respiratory and cardiocirculatory apparatus in the aged, offers difficulties connected both to surgical methods and to the perioperative evaluation and preparation of patients.
(13) Marked pain and great difficulty in introducing the apparatus made its use limited in respectively 15% and 14.5% of cases.
(14) The tasks which appeared to present the most difficulties for the patients were written spelling, pragmatic processing tasks like sentence disambiguation and proverb interpretation.
(15) In favorable cases, tRNA-DNA hybrids of length about 80 nucleotide pairs can be recognized (although with difficulty).
(16) The patient with the right posterior lesion could not recognize handwriting, was prosopagnosic and topographagnosic, but had no difficulty in reading, lipreading, or in recognizing stylized drawings.
(17) A review of the literature summarises the difficulties of diagnosis.
(18) The major difficulty encountered with the current technique is the danger of neurologic injury during the passage and handling of conventional wires, especially in extensive procedures.
(19) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(20) While mindful of the potential difficulties which attend its introduction into the treatment situation there is an attempt to balance this position through a consideration of the appropriate conditions and modes of operation under which a humor-enriched approach may be efficacious.
Harsh
Definition:
(a.) Rough; disagreeable; grating
(a.) disagreeable to the touch.
(a.) disagreeable to the taste.
(a.) disagreeable to the ear.
(a.) Unpleasant and repulsive to the sensibilities; austere; crabbed; morose; abusive; abusive; severe; rough.
(a.) Having violent contrasts of color, or of light and shade; lacking in harmony.
Example Sentences:
(1) Federal judges who blocked the bans cited harsh rhetoric employed by Trump on the campaign trail , specifically a pledge to ban all Muslims from entering the US and support for giving priority to Christian refugees, as being reflective of the intent behind his travel ban.
(2) The first problem facing Calderdale is sheep-rustling Happy Valley – filmed around Hebden Bridge, with its beautiful stone houses straight off the pages of the Guardian’s Lets Move To – may be filled with rolling hills and verdant pastures, but the reality of rural issues are harsh.
(3) On referral to our clinic, his physical examination and tape recording were characterized by harsh inspiratory stridor.
(4) There are harsh lessons in football and we have learned some over the last week.” Two James Milner penalties and goals from the impressive Adam Lallana, Sadio Mané and Philippe Coutinho took Liverpool’s tally to 24 in eight games.
(5) The tougher external environment in 2015 means that our businesses and functions need to work … to take a number of measures in response to the harsh trading environment,” Dudley said, according to a memo reported by Reuters.
(6) I couldn't shake the harsh words from my head and worried about if, or when, they would spill over into real life.
(7) A former senior CIA official said the secretary of state at the time, Colin Powell, eventually was informed about the program and sat in meetings in which harsh interrogation techniques were discussed.
(8) The results indicate the presence of carbohydrate epitopes buried within collagenous polypeptides that are exposed by harsh denaturing conditions.
(9) Official papers released by the National Archives show that the "wets" – notably Jim Prior, Peter Walker, Ian Gilmour, Mark Carlisle, Lord Soames and Francis Pym – were able to demonstrate that a majority of the cabinet rejected as unnecessarily harsh Sir Geoffrey Howe's demands for further public spending cuts and tax cuts.
(10) We report a case of a 17 year old boy who was referred for evaluation of a large anterior mediastinal mass, causing dyspnea and cough and resulting in a harsh systolic murmur.
(11) I appeal to the king of Saudi Arabia to exercise his power to halt the public flogging by pardoning Mr Badawi, and to urgently review this type of extraordinarily harsh penalty.” Badawi’s case was one of several recent prosecutions of activists.
(12) • Very robust questioning, known as the harsh approach, could be banned – or if not "the approach should not include an analogy with a military drill sergeant".
(13) He said he did not oppose the criminalisation of homosexuality but said imprisonment and the death penalty are too harsh.
(14) Fellow opposition activists and sympathisers took the harsh sentence as a sign that heavy jail terms awaited the rest.
(15) Pledge news: harsh • 26 Jan , Darragh MacAnthony, Peterborough chairman on the "incredibly harsh" abuse by fans of manager Mark Cooper: "Nobody has given the bloke a chance.
(16) But initial fan reaction to the first teaser trailers was harsh.
(17) The probability of skin-galvanic reaction appearance was harshly decreased.
(18) Offshore detention with increased isolation in remote and harsh circumstances exaggerates that adversity.
(19) Pictures of the concentration camps served to reinforce the necessity of the war and its unavoidably harsh economic legacy.
(20) If you're in doubt of the impact this can have, "brand imagery" studies show that when participants smoke the exact same cigarettes presented in lighter coloured packs, or in packs with "mild" in the name, they rate the smoke as lighter and less harsh, simply through the power of suggestion.