(n.) The state of being difficult, or hard to do; hardness; arduousness; -- opposed to easiness or facility; as, the difficulty of a task or enterprise; a work of difficulty.
(n.) Something difficult; a thing hard to do or to understand; that which occasions labor or perplexity, and requires skill and perseverance to overcome, solve, or achieve; a hard enterprise; an obstacle; an impediment; as, the difficulties of a science; difficulties in theology.
(n.) A controversy; a falling out; a disagreement; an objection; a cavil.
(n.) Embarrassment of affairs, especially financial affairs; -- usually in the plural; as, to be in difficulties.
Example Sentences:
(1) Technical factors that account for increased difficulty in these patients include: problems with guide catheter impaction and ostial trauma; inability to inflate the balloon with adequate guide catheter support; and need for increased intracoronary manipulation.
(2) To overcome this difficulty, a "hetero-antibody" RIA was studied.
(3) Epidemiological studies on low risks involve a number of major methodological difficulties.
(4) Mild swallowing difficulties occurred in 18 patients (39%), moderate dysfunction in 23 (50%), and severe dysfunction in five (11%).
(5) Reasons for non-acceptance do not indicate any major difficulties in the employment of such staff in general practice, at least as far as the patients are concerned.
(6) Spontaneous reports of suspected adverse reactions may be the only way of revealing very rare events but they present great difficulties of rational interpretation.
(7) The indication of the DNA probe method would be considered in the four cases as follows, 1. necessity of the special equipment to isolate the pathogen, 2. necessity of the long period to isolate the pathogen, 3. existence of the cross reaction among the pathogen and relative organisms in the immunological procedure, 4. existence of the difficulty to identify the species of the pathogen by the ordinary procedure.
(8) The 1-0-methylalduronic-acidmethylesters, obtained by the methanolysis of the polysaccharides, are reduced with boronhydrid to the corresponding methyl glycosides; there are split with acid to the aldoses, which are converted in pyridine with hydroxylamine to the aldoximes and than with acetic anhydride to the aldonitrilacetates, which can be separated by gaschromatography without difficulty.
(9) A control experiment demonstrated that changes in general arousal could not account for the effects of task difficulty on neuronal responses.
(10) In the anatomy laboratory we looked for an alternative approach to the glenohumeral joint which would accommodate these difficulties.
(11) A 27-year-old lady presented with history of discomfort in the throat and difficulty in swallowing for two weeks.
(12) Especially in the old patients (over 70 years) the incisional hernias represents an invalidating pathology whose treatment, for the high incidence of associated diseases of respiratory and cardiocirculatory apparatus in the aged, offers difficulties connected both to surgical methods and to the perioperative evaluation and preparation of patients.
(13) Marked pain and great difficulty in introducing the apparatus made its use limited in respectively 15% and 14.5% of cases.
(14) The tasks which appeared to present the most difficulties for the patients were written spelling, pragmatic processing tasks like sentence disambiguation and proverb interpretation.
(15) In favorable cases, tRNA-DNA hybrids of length about 80 nucleotide pairs can be recognized (although with difficulty).
(16) The patient with the right posterior lesion could not recognize handwriting, was prosopagnosic and topographagnosic, but had no difficulty in reading, lipreading, or in recognizing stylized drawings.
(17) A review of the literature summarises the difficulties of diagnosis.
(18) The major difficulty encountered with the current technique is the danger of neurologic injury during the passage and handling of conventional wires, especially in extensive procedures.
(19) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(20) While mindful of the potential difficulties which attend its introduction into the treatment situation there is an attempt to balance this position through a consideration of the appropriate conditions and modes of operation under which a humor-enriched approach may be efficacious.
Rub
Definition:
(v. t.) To subject (a body) to the action of something moving over its surface with pressure and friction, especially to the action of something moving back and forth; as, to rub the flesh with the hand; to rub wood with sandpaper.
(v. t.) To move over the surface of (a body) with pressure and friction; to graze; to chafe; as, the boat rubs the ground.
(v. t.) To cause (a body) to move with pressure and friction along a surface; as, to rub the hand over the body.
(v. t.) To spread a substance thinly over; to smear.
(v. t.) To scour; to burnish; to polish; to brighten; to cleanse; -- often with up or over; as, to rub up silver.
(v. t.) To hinder; to cross; to thwart.
(v. i.) To move along the surface of a body with pressure; to grate; as, a wheel rubs against the gatepost.
(v. i.) To fret; to chafe; as, to rub upon a sore.
(v. i.) To move or pass with difficulty; as, to rub through woods, as huntsmen; to rub through the world.
(n.) The act of rubbing; friction.
(n.) That which rubs; that which tends to hinder or obstruct motion or progress; hindrance; obstruction, an impediment; especially, a difficulty or obstruction hard to overcome; a pinch.
(n.) Inequality of surface, as of the ground in the game of bowls; unevenness.
(n.) Something grating to the feelings; sarcasm; joke; as, a hard rub.
(n.) Imperfection; failing; fault.
(n.) A chance.
(n.) A stone, commonly flat, used to sharpen cutting tools; a whetstone; -- called also rubstone.
Example Sentences:
(1) Neither acetylcholine nor leukotriene D4 altered tone of arterial rings after the endothelium had been intentionally disrupted by rubbing with a cotton-tipped applicator.
(2) Rubbed rings, but not intact ones, contracted when Ca2+ was added to a previously Ca2+-free medium containing angiotensin II or adrenaline.
(3) Immediately after eye rubbing the conjunctival epithelium was histologically disrupted and 50% of the mast cells showed evidence of degranulation.
(4) But this morning's right-of-centre national papers were determined to rub his nose in the dirt.
(5) Long-term rubbing of a pressure stocking and splint was believed to be responsible for breakdown in the graft of the patient who had a hypertrophic scar.
(6) I think we all pine for the good old days when politicians actually wrote bills, and bills actually became laws and can I rub your arms a little?
(7) The specific endonuclease Bam HI from Bacillus amyloliquefaciens (RUB 500) has been purified to apparent homogeneity.
(8) Ultz, who is also a well-known stage designer, is the only white person in the company - something the play rubs his nose in.
(9) Who was the asshole who threw the bottle?” Matt asked, rubbing his sore spot.
(10) The fibromas were transmitted by intradermal and subcutaneous inoculation and by rubbing the virus preparation into tattoo sites.
(11) With advancing age, the ATP-induced relaxation in the rubbed rings decreased and was abolished.
(12) In the Diagnostic and Statistical Manual of Mental Disorders, the American Psychiatric Association describes “frotteurism” as “recurrent, intense, or arousing sexual urges or fantasies, that involve touching and rubbing against a nonconsenting person”.
(13) Rubbed (endothelium-denuded) ring preparations at the age of 4-6 weeks showed a dose-dependent relaxation similar to that of the unrubbed rings.
(14) We found positive reactions in the prick test and rubbing test to the scales of the lizard Egernia cunninghami and others, which the patient kept as house-pets at this time or earlier.
(15) On the contrary, not all country dwellers are Tories; and fat cats, often Tory, will be rubbing their hands at the thought of asset-stripping another national resource.
(16) Ten rubs occurred in patients with pericardial effusion, five of whom had tamponade.
(17) But this will only rub more salt into the wounds at home.
(18) During each scratch cycle, the monoarticular knee extensor muscle is active when the limb rubs against the stimulated site, and there is rhythmic alternation between hip protractor and hip retractor muscle activity (Robertson et al., 1985).
(19) Oscar Pistorius rubs his face as he sits in the dock during his ongoing murder trial at a packed high court in Pretoria on May 5.
(20) Did it actually happen, that run of singles so strange and yet so strong that they rose to the higher reaches of the hit parade, rubbing shoulders with Showaddywaddy and the Nolans on Top of the Pops?