(n.) The state of being difficult, or hard to do; hardness; arduousness; -- opposed to easiness or facility; as, the difficulty of a task or enterprise; a work of difficulty.
(n.) Something difficult; a thing hard to do or to understand; that which occasions labor or perplexity, and requires skill and perseverance to overcome, solve, or achieve; a hard enterprise; an obstacle; an impediment; as, the difficulties of a science; difficulties in theology.
(n.) A controversy; a falling out; a disagreement; an objection; a cavil.
(n.) Embarrassment of affairs, especially financial affairs; -- usually in the plural; as, to be in difficulties.
Example Sentences:
(1) Technical factors that account for increased difficulty in these patients include: problems with guide catheter impaction and ostial trauma; inability to inflate the balloon with adequate guide catheter support; and need for increased intracoronary manipulation.
(2) To overcome this difficulty, a "hetero-antibody" RIA was studied.
(3) Epidemiological studies on low risks involve a number of major methodological difficulties.
(4) Mild swallowing difficulties occurred in 18 patients (39%), moderate dysfunction in 23 (50%), and severe dysfunction in five (11%).
(5) Reasons for non-acceptance do not indicate any major difficulties in the employment of such staff in general practice, at least as far as the patients are concerned.
(6) Spontaneous reports of suspected adverse reactions may be the only way of revealing very rare events but they present great difficulties of rational interpretation.
(7) The indication of the DNA probe method would be considered in the four cases as follows, 1. necessity of the special equipment to isolate the pathogen, 2. necessity of the long period to isolate the pathogen, 3. existence of the cross reaction among the pathogen and relative organisms in the immunological procedure, 4. existence of the difficulty to identify the species of the pathogen by the ordinary procedure.
(8) The 1-0-methylalduronic-acidmethylesters, obtained by the methanolysis of the polysaccharides, are reduced with boronhydrid to the corresponding methyl glycosides; there are split with acid to the aldoses, which are converted in pyridine with hydroxylamine to the aldoximes and than with acetic anhydride to the aldonitrilacetates, which can be separated by gaschromatography without difficulty.
(9) A control experiment demonstrated that changes in general arousal could not account for the effects of task difficulty on neuronal responses.
(10) In the anatomy laboratory we looked for an alternative approach to the glenohumeral joint which would accommodate these difficulties.
(11) A 27-year-old lady presented with history of discomfort in the throat and difficulty in swallowing for two weeks.
(12) Especially in the old patients (over 70 years) the incisional hernias represents an invalidating pathology whose treatment, for the high incidence of associated diseases of respiratory and cardiocirculatory apparatus in the aged, offers difficulties connected both to surgical methods and to the perioperative evaluation and preparation of patients.
(13) Marked pain and great difficulty in introducing the apparatus made its use limited in respectively 15% and 14.5% of cases.
(14) The tasks which appeared to present the most difficulties for the patients were written spelling, pragmatic processing tasks like sentence disambiguation and proverb interpretation.
(15) In favorable cases, tRNA-DNA hybrids of length about 80 nucleotide pairs can be recognized (although with difficulty).
(16) The patient with the right posterior lesion could not recognize handwriting, was prosopagnosic and topographagnosic, but had no difficulty in reading, lipreading, or in recognizing stylized drawings.
(17) A review of the literature summarises the difficulties of diagnosis.
(18) The major difficulty encountered with the current technique is the danger of neurologic injury during the passage and handling of conventional wires, especially in extensive procedures.
(19) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(20) While mindful of the potential difficulties which attend its introduction into the treatment situation there is an attempt to balance this position through a consideration of the appropriate conditions and modes of operation under which a humor-enriched approach may be efficacious.
Uphill
Definition:
(adv.) Upwards on, or as on, a hillside; as, to walk uphill.
(a.) Ascending; going up; as, an uphill road.
(a.) Attended with labor; difficult; as, uphill work.
Example Sentences:
(1) Distance running performance is slower on hilly race courses than flat courses even when the start and finish are at the same elevation, resulting in equal amounts of uphill and downhill running.
(2) Gillard faces an uphill battle convincing the electorate to back her.
(3) Like the parental strain, all three types of triple mutant showed moderate rates of downhill lactose transport and were defective in the uphill accumulation of sugars.
(4) The ascorbate oxidation was coupled to the uphill Na+ extrusion which was stimulated by CCCP and a penetrating weak base, diethylamine, as well as by valinomycin with or without diethylamine.
(5) Physiological strain was greater in uphill than in level or downhill walking (P less than .001).
(6) Senator Davis is a strong, viable, credible candidate who has raised a substantial amount of money and is the best candidate for Democrats – but it’s still an uphill battle,” he said.
(7) These results indicate that body posture can affect energy expenditure during uphill bicycling through factors unrelated to air resistance.
(8) It functions as a pair of easy-to-use skis for walking uphill, then when it’s time to head down, it quickly transforms into a toboggan for riding safely and enjoyably back to the resort, perhaps even with a few powder turns along the way.
(9) Speaking to the Guardian, Rotheram acknowledged the party faced an uphill struggle in a campaign the Tories are framing as a personality contest between party leaders.
(10) Stonewall does great work but the gay campaign for marriage equality faced an uphill struggle, which was made worse by Stonewall constantly undermining our efforts.
(11) It's going to be uphill for LA here - New York should be thinking: "No stupid penalties, no stupid penalties..." and repeat.
(12) As the transport of cefaclor showed no uphill uptake in the presence of a H+ gradient and its H+ stimulated uptake was small, a H+ gradient-independent carrier-mediated system seems to participate in its transport.
(13) The post-trial injection of 1 ng SP (in 0.5 microliter volume) led to significantly longer latencies in the uphill response.
(14) These are our treaty lands, and we need to protect clean water.’ Photograph: Sam Levin for the Guardian In a recent interview, Archambault acknowledged that the tribes face an uphill battle in the US judicial system: “We always knew that the federal court system was against Indian country.
(15) Heart rate and skiing velocities were analyzed over a flat, an uphill, and a downhill section, as well as for the total loop.
(16) Although efforts to win over Republican hawks appear close to gaining sufficient support in the Senate, the White House continues to face an uphill struggle to persuade enough members of Congress from both parties to authorise its planned strike against Syria in the House.
(17) We have a lot to do in the run up to 2020 – there’s a long road ahead of us and it will be an uphill struggle, but if we can mobilise more people, young and old, and continue to provide a real alternative to austerity and Obsornomics, we might just be in with a fighting chance.
(18) Dyspnoea grade 1 (shortness of breath when walking quickly on the level or uphill) was less well related to age.
(19) Transport of L-glutamic acid into the fission yeast Schizosaccharomyces pombe grown to the early stationary phase and preincubated for 60 min with 1% D-glucose is practically unidirectional and is mediated by a single uphill transport system with a KT of 170 microM and Jmax of 4.8 nmol min-1 (mg dry wt.)-1.
(20) It has been possible to form vesicles from the purified enzyme from Squalus acanthias and to demonstrate the ATP-dependent, ouabain inhibitable, coupled uphill transports of Na+ and K+.