(n.) The dried leaves of the purple foxglove (Digitalis purpurea), used in heart disease, disturbance of the circulation, etc.
Example Sentences:
(1) Lisinopril increases cardiac output, and decreases pulmonary capillary wedge pressure and mean arterial pressure in patients with congestive heart failure refractory to conventional treatment with digitalis and diuretics.
(2) The median blood levels were lower in hyperacidic subjects and higher in hypoacidic patients; the urinary excretion of the digitalis compound showed no essential differences.
(3) Three cases of simultaneous atrial and a-v junctional tachycardia, related to the administration of digitalis and occurring in a short period of 16 months, are reported.
(4) The model identified the following important variables: sex (relative risk (rr) = 2.4), beta-blocker withdrawal (rr = 2.1), performance on exercise test and digitalis treatment (rr = 2.3, P less than 0.05).
(5) The serum levels were correlated with the clinical signs of digitalis toxicity and the indications for determination of the serum digoxin concentration were established.
(6) The specificity of the treadmill test in patients who had received digitalis was 73%.
(7) There was no evidence of either myocardial infarction, abnormal electrolyte state, or digitalis intoxication.
(8) We also found that drugs with increase [Ca++]i, such as digitalis, exacerbated these abnormalities, whereas drugs that lower [Ca++]i, such as verapamil, or agents that increase cyclic AMP, such as forskolin, prevented them.
(9) The polar EDLF (ouabain-displacing compound 1; ODC-1) fulfills the criteria for the putative natriuretic and vasoactive digitalis-like factor.
(10) As part of a health examination of a representative sample (n = 8,000) of the adult Finnish population, cardiac state was assessed in the 747 digitalis users and the 6,329 non-users who participated in the survey.
(11) The present study demonstrates that adrenal glands removed from rats and then chopped release an immunoreactive digitalis-like material into a serum-free minimal incubation medium.
(12) These observations suggest that the diseased diabetic myocardium shows diminished sensitivity to digitalis toxicity.
(13) The prompt treatment by IV furosemide may be beneficial in the management of massive digitalis overdose.
(14) Prevention of digitalis toxicity in amiodarone-treated patients would therefore require monitoring of thyroid function every three to six months.
(15) Thus, their cyclopentanoperhydrophenanthrene or perhydrophenanthrene nuclei appear to serve as the minimal pharmacophoric lead structures for bimolecular recognition and to represent chemical models for the chemical nature of endogenous digitalis.
(16) Preoperative use of digitalis was found in 14 (31%) patients in group A and in 18 (12%) patients in group B (p less than 0.01).
(17) Mortality is significantly increased in the 20% to 30% of patients on digitalis who are in a toxic state when admitted to the hospital.
(18) The acute effects of oral enoximone on rest and exercise hemodynamics, ejection fraction, aerobic metabolism, exercise capacity, and arrhythmias were studied in 11 patients with moderate to moderately severe dilative cardiomyopathy after 8 days of enoximone (100 mg tid) in addition to baseline therapy (diuretics and digitalis).
(19) The digitalis-like substance (DLS), insulin resistance, and hyperglycemia are ascribed important roles in the pathogenesis of essential hypertension.
(20) All patients were pretreated with digitalis and diuretics, some also with conventional vasodilators.
Digoxin
Definition:
Example Sentences:
(1) For similar inotropic responses, normo- and hyperkalaemic dogs had similar levels of (Na+, K+)-ATPase inhibition and microsomal-bound digoxin.
(2) In this study, we examined renal tubular cell handling of digoxin and ouabain using LLC-PK1 cells, a model of proximal renal tubular cells.
(3) All patients received digoxin and low dose diuretic therapy.
(4) Pharmacokinetics of 3H-dihydrodigoxin and 3H-digoxin after single intravenous and intraduodenal administration in cats are compared.
(5) Digitalization by direct intramuscular injection of the fetus successfully controlled supraventricular tachycardia at 24 weeks' gestation after more traditional intensive trials of transplacental therapy with digoxin, verapamil, and procainamide, either separately or in combination, had failed.
(6) To investigate endogenous cardiac glycoside-like compounds in plasma and their ability to inhibit the sodium pump, digoxin-like immunoreactivity [digoxin-like immunoreactive substance(s), DLIS] and 86Rb uptake by erythrocytes were measured in plasma extracts from normal adults, hypertensive adults and neonates.
(7) Recently, this laboratory has demonstrated an enhanced susceptibility toward the development of ischemia-related lethal ventricular arrhythmias in the presence of therapeutic serum concentrations of digoxin in conscious dogs after myocardial infarction.
(8) Toxicity has been reported in the fetus of a woman ingesting a huge overdose of digitoxin; the same result would be anticipated with digoxin poisoning.
(9) Concentrations of DLIS were detectable in significantly more (58.3%) of the 12 CHF patients (group A) who were not receiving digoxin than in the 22 normal volunteers tested (13.6%) (P less than 0.05 by both chi-square and Fisher's exact test).
(10) The effects of coronary reperfusion on the uptake of digoxin by ischemic myocardium were studied in 17 open chest dogs undergoing anterior wall infarction produced by snaring confluent branches of the left coronary arterial system.
(11) However, drug therapy includes intravenous adenosine 6 mg, as well as the older standbys of digoxin, calcium and beta-blocking agents, and type 1a and 1c antiarrhythmias.
(12) The serum levels were correlated with the clinical signs of digitalis toxicity and the indications for determination of the serum digoxin concentration were established.
(13) Her heart failure initially improved with digoxin, furosemide, and enalapril.
(14) Analysis of digoxin serum concentrations, area under the curve, and the rate of elimination suggested no significant differences in digoxin parameters when combined with cimetidine.
(15) Thus, modification in the dosage regimen of digoxin may be unnecessary in the case of coadministration with captopril.
(16) In order to avoid false positive ischaemic ST-segment responses to exercise, a therapy with digoxin should be discontinued for at least 2 weeks before the exercise test.
(17) All measurements were performed during control and 30, 60, 90, and 120 min after digoxin administration.
(18) The subjects were studied after peroral intake of digoxin at 2 dose levels and after withdrawal of digoxin.
(19) Furthermore, concerning the effect of digoxin on the heart-rate, its use seems preferable to the use of sympathomimetic agents such as dobutamine, in patients with diffuse chronic dilatative myocardiopathy.
(20) We report initial data on the comparison of serum digoxin levels after administration of the drug to dogs through both the intraosseous and intravenous routes.