(n.) The dried leaves of the purple foxglove (Digitalis purpurea), used in heart disease, disturbance of the circulation, etc.
Example Sentences:
(1) Lisinopril increases cardiac output, and decreases pulmonary capillary wedge pressure and mean arterial pressure in patients with congestive heart failure refractory to conventional treatment with digitalis and diuretics.
(2) The median blood levels were lower in hyperacidic subjects and higher in hypoacidic patients; the urinary excretion of the digitalis compound showed no essential differences.
(3) Three cases of simultaneous atrial and a-v junctional tachycardia, related to the administration of digitalis and occurring in a short period of 16 months, are reported.
(4) The model identified the following important variables: sex (relative risk (rr) = 2.4), beta-blocker withdrawal (rr = 2.1), performance on exercise test and digitalis treatment (rr = 2.3, P less than 0.05).
(5) The serum levels were correlated with the clinical signs of digitalis toxicity and the indications for determination of the serum digoxin concentration were established.
(6) The specificity of the treadmill test in patients who had received digitalis was 73%.
(7) There was no evidence of either myocardial infarction, abnormal electrolyte state, or digitalis intoxication.
(8) We also found that drugs with increase [Ca++]i, such as digitalis, exacerbated these abnormalities, whereas drugs that lower [Ca++]i, such as verapamil, or agents that increase cyclic AMP, such as forskolin, prevented them.
(9) The polar EDLF (ouabain-displacing compound 1; ODC-1) fulfills the criteria for the putative natriuretic and vasoactive digitalis-like factor.
(10) As part of a health examination of a representative sample (n = 8,000) of the adult Finnish population, cardiac state was assessed in the 747 digitalis users and the 6,329 non-users who participated in the survey.
(11) The present study demonstrates that adrenal glands removed from rats and then chopped release an immunoreactive digitalis-like material into a serum-free minimal incubation medium.
(12) These observations suggest that the diseased diabetic myocardium shows diminished sensitivity to digitalis toxicity.
(13) The prompt treatment by IV furosemide may be beneficial in the management of massive digitalis overdose.
(14) Prevention of digitalis toxicity in amiodarone-treated patients would therefore require monitoring of thyroid function every three to six months.
(15) Thus, their cyclopentanoperhydrophenanthrene or perhydrophenanthrene nuclei appear to serve as the minimal pharmacophoric lead structures for bimolecular recognition and to represent chemical models for the chemical nature of endogenous digitalis.
(16) Preoperative use of digitalis was found in 14 (31%) patients in group A and in 18 (12%) patients in group B (p less than 0.01).
(17) Mortality is significantly increased in the 20% to 30% of patients on digitalis who are in a toxic state when admitted to the hospital.
(18) The acute effects of oral enoximone on rest and exercise hemodynamics, ejection fraction, aerobic metabolism, exercise capacity, and arrhythmias were studied in 11 patients with moderate to moderately severe dilative cardiomyopathy after 8 days of enoximone (100 mg tid) in addition to baseline therapy (diuretics and digitalis).
(19) The digitalis-like substance (DLS), insulin resistance, and hyperglycemia are ascribed important roles in the pathogenesis of essential hypertension.
(20) All patients were pretreated with digitalis and diuretics, some also with conventional vasodilators.
Foxglove
Definition:
(n.) Any plant of the genus Digitalis. The common English foxglove (Digitalis purpurea) is a handsome perennial or biennial plant, whose leaves are used as a powerful medicine, both as a sedative and diuretic. See Digitalis.
Example Sentences:
(1) The therapeutic efficacy of captopril, the inhibitor of the angiotensin-converting enzyme was studied in 18 patients with noticeable chronic cardiac insufficiency, who were refractory to foxglove drugs and diuretics.
(2) This review highlights Withering's experience with "the foxglove," and summarizes modern concepts of digitalis efficacy and toxicity.
(3) Of the plants tested, 5 (oleander, lupine, foxglove, yew leaves, and dieffenbachia) were considered highly toxic and were associated with acute death of birds.
(4) Withering's (1741-1799) greatest merit is not so much that of having discovered the therapeutic value of foxglove in hydropsy, since this indication (among others) was already part of traditional medicine, but actually during a decade of carefully recording clinical observations, he authoritatively settled definite guidelines for its use.
(5) Progesterone 5 alpha-reductase, which catalyses the reduction of progesterone to 5 alpha-pregnane-3,20-dione, was isolated and characterized from cell cultures of Digitalis lanata (foxglove).
(6) This year we are celebrating the bicentenary of the publication, by William Withering, of An Account of the Foxglove and Some of its Medicinal Uses with Practical Remarks on Dropsy and Other Diseases (1).
(7) Foxglove plants were found in the pasture and their poisonous potential seemed to fit the post mortem findings and clinical signs.
(8) The diagnosis was confirmed by chemical analysis of tissues and botanical examination of rumen contents, and a similar fatality was produced in a penned red deer by test dosing with powdered foxglove leaves.
(9) Cytochrome P-450-dependent digitoxin 12 beta-hydroxylase from cell cultures of foxglove (Digitalis lanata) was solubilized from microsomal membranes with CHAPS (3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulphonic acid).
(10) Over 200 years age, William Withering described the advantages which might be gained by the considered use of extracts of the foxglove, digitalis purpurea, in patients with congestive heart failure, particularly if the rhythm was irregular.
(11) It is said that William Withering's discovery of digitalis arose out of curiosity engendered during a stage-coach journey, by witnessing an old woman collecting foxgloves by the side of the road.
(12) Just as foxgloves had been used traditionally for centuries to treat 'afflictions of the heart', the plant Artemesia annua has been used as a treatment for fever in China for almost two thousand years.
(13) It is concluded that foxglove poisoning may be an occasional hazard in the husbanding of red deer.
(14) The Foxglove Saga (1960) was undoubtedly promising, and was undoubtedly helped by the name Waugh.
(15) Withering prepared digitalis from the purple foxglove and wrote a standard work on the cultivation of vegetables.
(16) In spite of its further utilization in many additional illnesses such as madness, foxglove, and later its main heteroside digitoxine, progressively reached their eventual place in the treatment of supraventricular arrhythmias and in congestive heart failure.