(1) For similar inotropic responses, normo- and hyperkalaemic dogs had similar levels of (Na+, K+)-ATPase inhibition and microsomal-bound digoxin.
(2) In this study, we examined renal tubular cell handling of digoxin and ouabain using LLC-PK1 cells, a model of proximal renal tubular cells.
(3) All patients received digoxin and low dose diuretic therapy.
(4) Pharmacokinetics of 3H-dihydrodigoxin and 3H-digoxin after single intravenous and intraduodenal administration in cats are compared.
(5) Digitalization by direct intramuscular injection of the fetus successfully controlled supraventricular tachycardia at 24 weeks' gestation after more traditional intensive trials of transplacental therapy with digoxin, verapamil, and procainamide, either separately or in combination, had failed.
(6) To investigate endogenous cardiac glycoside-like compounds in plasma and their ability to inhibit the sodium pump, digoxin-like immunoreactivity [digoxin-like immunoreactive substance(s), DLIS] and 86Rb uptake by erythrocytes were measured in plasma extracts from normal adults, hypertensive adults and neonates.
(7) Recently, this laboratory has demonstrated an enhanced susceptibility toward the development of ischemia-related lethal ventricular arrhythmias in the presence of therapeutic serum concentrations of digoxin in conscious dogs after myocardial infarction.
(8) Toxicity has been reported in the fetus of a woman ingesting a huge overdose of digitoxin; the same result would be anticipated with digoxin poisoning.
(9) Concentrations of DLIS were detectable in significantly more (58.3%) of the 12 CHF patients (group A) who were not receiving digoxin than in the 22 normal volunteers tested (13.6%) (P less than 0.05 by both chi-square and Fisher's exact test).
(10) The effects of coronary reperfusion on the uptake of digoxin by ischemic myocardium were studied in 17 open chest dogs undergoing anterior wall infarction produced by snaring confluent branches of the left coronary arterial system.
(11) However, drug therapy includes intravenous adenosine 6 mg, as well as the older standbys of digoxin, calcium and beta-blocking agents, and type 1a and 1c antiarrhythmias.
(12) The serum levels were correlated with the clinical signs of digitalis toxicity and the indications for determination of the serum digoxin concentration were established.
(13) Her heart failure initially improved with digoxin, furosemide, and enalapril.
(14) Analysis of digoxin serum concentrations, area under the curve, and the rate of elimination suggested no significant differences in digoxin parameters when combined with cimetidine.
(15) Thus, modification in the dosage regimen of digoxin may be unnecessary in the case of coadministration with captopril.
(16) In order to avoid false positive ischaemic ST-segment responses to exercise, a therapy with digoxin should be discontinued for at least 2 weeks before the exercise test.
(17) All measurements were performed during control and 30, 60, 90, and 120 min after digoxin administration.
(18) The subjects were studied after peroral intake of digoxin at 2 dose levels and after withdrawal of digoxin.
(19) Furthermore, concerning the effect of digoxin on the heart-rate, its use seems preferable to the use of sympathomimetic agents such as dobutamine, in patients with diffuse chronic dilatative myocardiopathy.
(20) We report initial data on the comparison of serum digoxin levels after administration of the drug to dogs through both the intraosseous and intravenous routes.
Foxglove
Definition:
(n.) Any plant of the genus Digitalis. The common English foxglove (Digitalis purpurea) is a handsome perennial or biennial plant, whose leaves are used as a powerful medicine, both as a sedative and diuretic. See Digitalis.
Example Sentences:
(1) The therapeutic efficacy of captopril, the inhibitor of the angiotensin-converting enzyme was studied in 18 patients with noticeable chronic cardiac insufficiency, who were refractory to foxglove drugs and diuretics.
(2) This review highlights Withering's experience with "the foxglove," and summarizes modern concepts of digitalis efficacy and toxicity.
(3) Of the plants tested, 5 (oleander, lupine, foxglove, yew leaves, and dieffenbachia) were considered highly toxic and were associated with acute death of birds.
(4) Withering's (1741-1799) greatest merit is not so much that of having discovered the therapeutic value of foxglove in hydropsy, since this indication (among others) was already part of traditional medicine, but actually during a decade of carefully recording clinical observations, he authoritatively settled definite guidelines for its use.
(5) Progesterone 5 alpha-reductase, which catalyses the reduction of progesterone to 5 alpha-pregnane-3,20-dione, was isolated and characterized from cell cultures of Digitalis lanata (foxglove).
(6) This year we are celebrating the bicentenary of the publication, by William Withering, of An Account of the Foxglove and Some of its Medicinal Uses with Practical Remarks on Dropsy and Other Diseases (1).
(7) Foxglove plants were found in the pasture and their poisonous potential seemed to fit the post mortem findings and clinical signs.
(8) The diagnosis was confirmed by chemical analysis of tissues and botanical examination of rumen contents, and a similar fatality was produced in a penned red deer by test dosing with powdered foxglove leaves.
(9) Cytochrome P-450-dependent digitoxin 12 beta-hydroxylase from cell cultures of foxglove (Digitalis lanata) was solubilized from microsomal membranes with CHAPS (3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulphonic acid).
(10) Over 200 years age, William Withering described the advantages which might be gained by the considered use of extracts of the foxglove, digitalis purpurea, in patients with congestive heart failure, particularly if the rhythm was irregular.
(11) It is said that William Withering's discovery of digitalis arose out of curiosity engendered during a stage-coach journey, by witnessing an old woman collecting foxgloves by the side of the road.
(12) Just as foxgloves had been used traditionally for centuries to treat 'afflictions of the heart', the plant Artemesia annua has been used as a treatment for fever in China for almost two thousand years.
(13) It is concluded that foxglove poisoning may be an occasional hazard in the husbanding of red deer.
(14) The Foxglove Saga (1960) was undoubtedly promising, and was undoubtedly helped by the name Waugh.
(15) Withering prepared digitalis from the purple foxglove and wrote a standard work on the cultivation of vegetables.
(16) In spite of its further utilization in many additional illnesses such as madness, foxglove, and later its main heteroside digitoxine, progressively reached their eventual place in the treatment of supraventricular arrhythmias and in congestive heart failure.