(n.) A silver coin of the United States, of the value of ten cents; the tenth of a dollar.
Example Sentences:
(1) [pGlu5,MePhe8,-MeGly9]-substance P 5 - 11 (DiMe-C7), senktide and septide did not contract the aorta.
(2) Subcutaneous administration of ondansetron (GR38032) (0.001-0.3 mg kg-1), GR65630 (0.01 mg kg-1), ICS 205-930 (0.1 mg kg-1) and MDL 72222 (0.1 mg kg-1), inhibited the DiMe-C7-induced hyperactivity response.
(3) The interaction of DiME-SP with spinal cord SP receptors was evaluated initially in binding studies.
(4) On the other hand, in 2 neurones a response was exclusively evoked by DiMe-C7.
(5) Like PGE1, 16-diMe-PGE2 has a dual action on the intact canine pancreas (stimulation of enzymes and inhibition of volume and electrolytes), but is much more potent, has a prolonged action, and is active intraduodenally and intragastrically.
(6) The role of spinal cord substance P (SP) in regulating sympathetic outflow to the cardiovascular system was assessed with the stable active analog [pGlu5,MePhE8,MeGly9]-SP(5-11) (DiME-SP).
(7) The rapid dissociation of the compounds displaying antiglucocorticoid activity contrasted with the slow dissociation of DX diMe.
(8) Activities in this field have been enhanced by the interests of such health-related entities as the National Foundation-March of Dimes and the Robert Wood Johnson Foundation in these studies.
(9) Esterification of the carboxyl groups of meso-DMSA changes its coordination properties in that the two sulfur atoms of DiMe-meso-DMSA are used to coordinate with Hg2+, Cd2+, or Pb2+.
(10) The study was conducted in a blinded manner and consisted of 50 attempts equally divided among pennies, nickels, dimes, quarters, and controls (no coin).
(11) I will not ask students or seniors or middle-class families to pay down the entire deficit while people making over $250,000 aren't asked to pay a dime more in taxes."
(12) He is a reminder that being black in America, no matter how light or dark skinned you are, means shielding yourself against the inevitable arbitrary assessment of your worth at the drop of a dime.
(13) Rats received one microinjection (0.5 microliter) of SP (0.74 pmol), of the N-terminal fragment SP (1-7) and the C-terminal fragment analog DiMe-C7 (each at doses of 0.074, 0.74, and 74 pmol), or vehicle (phosphate-buffered saline; PBS).
(14) In contrast, infusions of DiMe-C7 or SP into the lateral ventricles or microinfusions of SP into VTA failed to elicit increases in DOPAC levels in forebrain.
(15) Treatment of the hepatocytes with dithiothreitol, following 4 min exposure of the cells to 3,5-diMe NAPQI, reversed the quinone imine-induced changes in nucleotide levels and reduced the cytotoxicity.
(16) Saturable, high-affinity binding of [125I]Bolton-Hunter-SP to rat spinal cord membranes was dose-dependently inhibited by DiME-SP (IC50 = 1.5 microM).
(17) Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other regions of forebrain.
(18) I have to cut through the bullshit and just say what I really mean.” I was so concerned about impressing other academics; I never used a dime word if I had a dollar one in my pocket It also helps when scholars can appreciate the value of an editor, she adds.
(19) Immediately after the training trial, rats were injected with 0.74 pmol SP or equimolar dosed SP(1-7), DIME-C7, or SP(7-11).
(20) Why bow your head to people who will simply bank the genuflection, and then turn on the head of a dime.
Dire
Definition:
(superl.) Ill-boding; portentous; as, dire omens.
(superl.) Evil in great degree; dreadful; dismal; horrible; terrible; lamentable.
Example Sentences:
(1) Why is it so surprising to people that a boy like Chol, just out of conflict, has thought through the needs of his country in such a detailed way?” While Beah’s zeal is laudable, the situation in South Sudan is dire .
(2) It is that beautiful moment when the original Metamorphosis is destroyed so that it can be refashioned for a global community of readers in dire need of new forms of storytelling.
(3) In this investigation, reanalysis of responses to case vignettes obtained from 436 psychologists, psychiatrists, and internists revealed that on the issue of confidentiality management, these health care providers discriminate among cases involving: Premeditated harm to others, socially irresponsible acts with possible dire consequences to self or others, and minor theft.
(4) The report’s concluding chapters raised dire warning that the operations of contemporary child protection agencies were replicating many of the destructive dynamics of the Stolen Generations era.
(5) Tim Cook, the CEO of Apple, warned Barack Obama in public remarks this month that history had shown “sacrificing our right to privacy can have dire consequences”.
(6) Algeria had not scored a World Cup goal since they drew 1-1 with Northern Ireland at Mexico 1986, a run that took in five matches, including that dire 0-0 draw with England in Cape Town four years ago.
(7) Professor Lord Stern of the London School of Economics, the author of the influential Stern Report into the economics of climate change for the Treasury in 2006, warned that if the pattern continued, the results would be dire.
(8) High among the range of issues was the media dominance of the Globo group (whose journalists were chased away from demonstrations by an irate mob), inefficient use of public funds, forced relocations linked to Olympic real estate developments, the treatment of indigenous groups, dire inequality and excessive use of force by police in favela communities.
(9) Burrows had resigned as governor of Bank of Ireland, leaving the lender in dire straits, with big losses and mounting debt threatening its very survival.
(10) Yet the inability to get on in life is a now a major and growing problem for middle-class children and this group is in dire need of attention, it is expected to report.
(11) Vince Cable, their shadow chancellor, said: "The Liberal Democrats welcome the government's recognition that radical action is now needed, reflecting the dire and deteriorating position of the UK economy.
(12) Its willingness to ignore diplomatic convention and use its Kuala Lumpur embassy to conduct an extraterritorial assassination will be seen as setting a dire precedent that cannot be allowed to stand.
(13) What is clear, however, is that the reported escalation in fighting exacerbates the already dire humanitarian and human rights situation and the suffering of the Yemeni people,” said Ban’s spokesman, Farhan Haq.
(14) In a scene of young soldiers at rest for a few minutes at the front, he takes us into their heads: one full of dire forebodings, another singing, one trying to identify a bird on a tree – soldiers dreaming of girls’ breasts, dogs, sausages and poetry.
(15) Despite its own dire predictions on the potential impact of climate change , the government's impact assessment for Flood Re does not take account of " changing flood risk due to deterioration of existing flood defences [or] climate change".
(16) The situation is so dire the National Audit Office has warned that by 2020 schools will be worse funded than at any time since the mid-90s.
(17) John Macgregor, an aid worker who has been accompanying teams delivering food and water to Battambang, described the area as a vast inland sea where conditions are dire and malnutrition is common.
(18) But they are also the stuff of nightmares, because if an electricity grid is overwhelmed by demand, the consequences can be dire, as India discovered recently , when more than 700 million people were left without power.
(19) Thousands of jobs that would have been created will be lost and the knock-on effect will be so dire.
(20) While big businesses have enjoyed access to new couriers, Royal Mail itself eventually reached such a dire state that the Hooper report urged the government to rewrite the law to clarify that competition was a mixed blessing.