(1) Noise exposure and demographic data applicable to the United States, and procedures for predicting noise-induced permanent threshold shift (NIPTS) and nosocusis, were used to account for some 8.7 dB of the 13.4 dB average difference between the hearing levels at high frequencies for otologically and noise screened versus unscreened male ears; (this average difference is for the average of the hearing levels at 3000, 4000, and 6000 Hz, average for the 10th, 50th, and 90th percentiles, and ages 20-65 years).
(2) After 1 h, NIPt gave a recovery ratio of 1.3-1.4, and after 2-4 h the recovery ratio was 1.7-2.6.
(3) The noise-induced permanent threshold shift (NIPTS) resultings form up to ten years of exposure to an average A-weighted sound level Leq of 89 dB was investigated.
(4) NIPt and Pt(terpy) were examined at both 10 microM and 25 microM for their ability to inhibit potentially lethal damage recovery after bleomycin treatment.
(5) The dose modifying factors obtained with 200 microM and 400 microM trans-bis(2-nitroimidazole)dichloroplatinum II (NIPt) in hypoxic cells were 1.5 and 2.1, respectively.
(6) The relation between noise-induced permanent threshold shift (NIPTS) and vibration-induced dysfunction in the digital circulation was examined in a longitudinal survey among forest workers.
(7) During the follow-up period, the gap in NIPTS between the two groups did not increase.
(8) The forest workers with digital vasospasms had significantly greater NIPTS at 4,000 and 8,000 Hz than the symptom-free referents.
(9) This increase in susceptibility to NIPTS is further accentuated by approximately 5 to 10 dB for impulses whose spectra peak at 2 kHz.
(10) The potential of cis-diamminedichloroplatinum(II) (CDDP), trans-di(2-nitroimidazole)dichloro-platinum(II) (NIPt), trans-di(2-amino-5-nitrothiazole)dichloroplatinum(II) (Plant), cis-(1,2-diamino-4-nitrobenzene)dichloroplatinum(II) (Plato), and cis-di-pyridinedichloroplatinum(II) (PyPt) to act as chemosensitizers of mitomycin C cytotoxicity toward EMT6 cells under oxygenated and hypoxic conditions has been assessed.
(11) The above findings thus imply that the cause of NITTS (Noise-Induced Temporary Threshold Shift) and NIPTS (Noise-Induced Permanent Threshold Shift) lies in impaired blood flow due to vasoconstriction of the inner ear capillary.
(12) Data concerning deterioration in hearing threshold levels at 4000 Hz due to aging in war veterans with NIPTS do not support the Bies and Hansen assumption but provide support for the formula for combining presbycusis and NIPTS incorporated in International Standard ISO 1999.
(13) With 0.01 microM NIPT a 15-23-fold enhancement of mitomycin C cytotoxicity was observed.
(14) Presumed NIPTS was calculated by correcting each individual audiogram of the exposed subjects according to the aging curves developed from the control population hearing levels.
(15) The cytotoxicities of cis-diamminedichloroplatinum(II) (CDDP) and of three recently developed dichloro complexes of bivalent platinum with radiosensitizing ligands [(1,2-diamino-4-nitrobenzene)dichloroplatinum(II) (Plato), trans-bis(2-amino-5-nitrothiazole)dichloroplatinum(II) (Plant), and trans-bis(2-nitroimidazole)dichloroplatinum(II) (NIPt)] were evaluated at 37 degrees C, 42 degrees C, and 43 degrees C at normal pH, at pH 6.45, and under normally oxygenated and hypoxic conditions in EMT6 cells in vitro.
(16) The third postulate was that NIPTS produced by 10 years of daily exposure is approximately equal to the TTS2 produced by the same noise after an 8-h exposure.
(17) The results indicated a considerable male-female difference in NIPTS, even though both groups were exposed to the same Leq.
(18) 88, 2743-2754 (1990)] have proposed an alternative formulation of the relationship between noise exposure and noise-induced hearing impairment to that presented in International Standard ISO 1999, in which they assume that presbycusis and noise-induced permanent threshold shift (NIPTS) are additive on an antilogarithm basis.
(19) The results suggest that vibration-induced activation of the autonomic nervous system, which is thought to elicit digital vasospasms, may also contribute to the development of NIPTS.
(20) The results show that there is an increasing susceptibility to NIPTS as the audiometric test frequency increases from 0.5 to 16 kHz.