(superl.) Evil in great degree; dreadful; dismal; horrible; terrible; lamentable.
Example Sentences:
(1) Why is it so surprising to people that a boy like Chol, just out of conflict, has thought through the needs of his country in such a detailed way?” While Beah’s zeal is laudable, the situation in South Sudan is dire .
(2) It is that beautiful moment when the original Metamorphosis is destroyed so that it can be refashioned for a global community of readers in dire need of new forms of storytelling.
(3) In this investigation, reanalysis of responses to case vignettes obtained from 436 psychologists, psychiatrists, and internists revealed that on the issue of confidentiality management, these health care providers discriminate among cases involving: Premeditated harm to others, socially irresponsible acts with possible dire consequences to self or others, and minor theft.
(4) The report’s concluding chapters raised dire warning that the operations of contemporary child protection agencies were replicating many of the destructive dynamics of the Stolen Generations era.
(5) Tim Cook, the CEO of Apple, warned Barack Obama in public remarks this month that history had shown “sacrificing our right to privacy can have dire consequences”.
(6) Algeria had not scored a World Cup goal since they drew 1-1 with Northern Ireland at Mexico 1986, a run that took in five matches, including that dire 0-0 draw with England in Cape Town four years ago.
(7) Professor Lord Stern of the London School of Economics, the author of the influential Stern Report into the economics of climate change for the Treasury in 2006, warned that if the pattern continued, the results would be dire.
(8) High among the range of issues was the media dominance of the Globo group (whose journalists were chased away from demonstrations by an irate mob), inefficient use of public funds, forced relocations linked to Olympic real estate developments, the treatment of indigenous groups, dire inequality and excessive use of force by police in favela communities.
(9) Burrows had resigned as governor of Bank of Ireland, leaving the lender in dire straits, with big losses and mounting debt threatening its very survival.
(10) Yet the inability to get on in life is a now a major and growing problem for middle-class children and this group is in dire need of attention, it is expected to report.
(11) Vince Cable, their shadow chancellor, said: "The Liberal Democrats welcome the government's recognition that radical action is now needed, reflecting the dire and deteriorating position of the UK economy.
(12) Its willingness to ignore diplomatic convention and use its Kuala Lumpur embassy to conduct an extraterritorial assassination will be seen as setting a dire precedent that cannot be allowed to stand.
(13) What is clear, however, is that the reported escalation in fighting exacerbates the already dire humanitarian and human rights situation and the suffering of the Yemeni people,” said Ban’s spokesman, Farhan Haq.
(14) In a scene of young soldiers at rest for a few minutes at the front, he takes us into their heads: one full of dire forebodings, another singing, one trying to identify a bird on a tree – soldiers dreaming of girls’ breasts, dogs, sausages and poetry.
(15) Despite its own dire predictions on the potential impact of climate change , the government's impact assessment for Flood Re does not take account of " changing flood risk due to deterioration of existing flood defences [or] climate change".
(16) The situation is so dire the National Audit Office has warned that by 2020 schools will be worse funded than at any time since the mid-90s.
(17) John Macgregor, an aid worker who has been accompanying teams delivering food and water to Battambang, described the area as a vast inland sea where conditions are dire and malnutrition is common.
(18) But they are also the stuff of nightmares, because if an electricity grid is overwhelmed by demand, the consequences can be dire, as India discovered recently , when more than 700 million people were left without power.
(19) Thousands of jobs that would have been created will be lost and the knock-on effect will be so dire.
(20) While big businesses have enjoyed access to new couriers, Royal Mail itself eventually reached such a dire state that the Hooper report urged the government to rewrite the law to clarify that competition was a mixed blessing.
Vire
Definition:
(n.) An arrow, having a rotary motion, formerly used with the crossbow. Cf. Vireton.
Example Sentences:
(1) The virE locus that is responsible for the efficiency of infection by Agrobacterium tumefaciens (T. Hirooka and C. Kado, J. Bacteriol.
(2) Of six vir region complementation groups (virA, virB, virG, virC, virD, and virE) examined by using fusions to reporter genes, the promoters of only two (virC and virD) responded to the ros mutation.
(3) Mutations in these loci eliminate (virA, virB, virD and virG) or significantly restrict (virC and virE) the ability of Agrobacterium to transform plant cells.
(4) The promoter region of virE was analyzed by using gene fusions to promoterless cat and lux genes.
(5) One inducible complex is determined by the virE locus, two Ti-plasmid-dependent complexes are constitutively expressed, and a fourth one is controlled by chromosomal genes.
(6) Deletion of this vir box only completely abolished induction of the virE gene.
(7) "The main allegation is that senior officials at Revenue and Customs have acted ultra vires [beyond their powers] and we are duty bound to take that seriously," she said.
(8) Genetic complementation with mutant and wild-type alleles led to the identification of the virE locus at the right boundary, which was located about 6 kilobases from the left border of the segment of DNA that is transferred into the plant genome.
(9) To investigate the minimum sequences necessary for vir gene induction a deletion derivative of virE that lacks the vir box region was used.
(10) According to the whistleblower's submission to the committee, the estimate of future profits is ultra vires .
(11) Virulence of a virE2 mutant was restored by mixed infection with strains carrying an intact vir region, but not with virA, virB, virD, virE, or virG mutants or chvA, chvB, or exoC mutants.
(12) virE is transcribed from left to right toward the T region.
(13) We established the kinetics of induction for virB, virD, virE, and virG by using lacZ fusions, and we found that the virB mutant strain could not adapt to this low-pH medium unless 1 mM CaCl2 was added.
(14) Active vir fragments contained the strongly acetosyringone-inducible promoters of virB, virC, virD, and virE and the weakly inducible promoters of virA and virG.
(15) virE operon constructs with specific lesions in either virE1 or virE2 were impaired for complementation of pTiA6 delta E. Several mutations specific for the promoter-proximal virE1 locus appeared to have a polar effect on expression of the virE2-encoded 60-kDa protein.
(16) In the present communication, we have analyzed the virE operon at the molecular level.
(17) The virulence regulon of the Agrobacterium tumefaciens TiC58 plasmid is composed of six operons, virA, virB, virG, virC, virD and virE, which direct the transfer of T-DNA into plant cells.
(18) The nucleotide sequence of virE revealed three open reading frames, arranged as an operon, with a potential coding capacity for proteins of 9, 7.1, and 63.5 kilodaltons.
(19) This locus is very similar to the virE locus of octopine type Ti plasmids on the basis of nucleotide and amino acid sequence comparisons as well as genetic complementation analyses.
(20) virE is 2.0 kilobases long and encodes at least one protein of 69 kilodaltons.