(n.) A selenide containing two atoms of selenium in each molecule.
Example Sentences:
(1) We described a production of IFN-gamma and TNF-alpha by various subsets of PBL stimulated with 2-phenyl-1,2-benzisoselenazol-3(2H)-one (ebselen) or bis [2-(N-phenyl-carbamoyl)]phenyl diselenide.
(2) SR that had been extensively labeled with the diselenide spin label was resistant to ATPase inactivation by potent oxidants that arise when myoglobin reacts with hydroperoxides.
(3) The riductive scission of a diselenide (selenocystamine) produced by disulfide gives the perselenosulfide, a new compound.
(4) After reaction between ebselen and L(SH)2 the diselenide of ebselen was immediately detected.
(5) 5-Selenium-substituted derivatives (diselenides) or uracil, 2'-deoxyuridine, and 2'-deoxyuridylic acid were synthesized via the addition of methyl hypobromite to the 5,6 double bond, followed by reaction of the adducts with sodium diselenide.
(6) Furthermore, it is likely that a selenol is an intermediate in diselenide formation.
(7) This glutathione oxidase activity required the heterolytic reduction of the diselenide bond, which produced two equivalents of the selenolate derivative selenocysteamine (RSe-), via the transient formation of a selenenylsulfide intermediate (RSe-SG).
(8) The second order rate constants for the reaction of ebselen (0.29 mM-1 min-1), ebselen-glutathione selenosulfide (less than or equal to 0.01 mM-1 min-1), ebselen selenol (2.8 mM-1 min-1) and ebselen diselenide (0.32 mM-1 min-1) with hydrogen peroxide reveal that the selenol is particularly active in this respect.
(9) We tested the antiproliferative effects of Diheptyl Diselenide (DHDSe) on several different human cancer cell lines.
(10) Under these conditions, BSC was partially converted to dibenzyl diselenide (DDS) and phenylmethaneseleninic acid.
(11) No additional cytotoxicity due to the selenium atom was observed, with the exception of diselenide (-SeSe-) compounds.
(12) These observations suggest that electrostatic interactions affect the reductive cleavage of diselenide and selenenylsulfide linkages.
(13) Specificity studies reveal that variation of the N-substituent in the benzisoselenazolone system does not influence cytochrome P-450 inactivation, whereas ebselen derivatives with methylated or glucuronidated selenium moiety as well as diselenides do not convert cytochrome P-450 to P-420.
(14) On the other hand, membranes that had been extensively treated with the diselenide spin label and were then subjected to these peroxide treatments were fully active after mercaptoethanol-mediated cleavage of the thioselenides.
(15) Sodium dodecyl sulfate gel electrophoresis showed that peroxide-mediated crosslinking of ATPase observed in unmodified SR membranes did not occur in the diselenide-modified SR membranes.
(16) The determination of the relative amounts of ebselen selenol and diselenide under typical peroxidase assay conditions implies that the selenol is the predominant molecular species responsible for the glutathione--(70%)--and dithiothreitol--(96%)--dependent peroxidase activity of ebselen.
(17) The most active cytokine inducers were: 2-phenyl-1,2-benzisoselenazol-3(2H)-one (1, ebselen), bis [2-(N-phenylcarbamoyl)]phenyl diselenide (7) and bis (2-[N-(2-pyridyl)carbamoyl])phenyl diselenide (8).
(18) Protein mixed thioselenides formed by reaction of sarcoplasmic reticulum (SR) with diselenide biradical spin labels were quantified by ESR.
(19) The fast formation of the diselenide with L(SH)2 versus the slow formation of the diselenide with GSH accounts for our observation that L(SH)2 is a better cofactor than GSH in the peroxidase activity of ebselen.
(20) Finally the diselenide reacts with a peroxide and ebselen is regenerated.
Inorganic
Definition:
(a.) Not organic; without the organs necessary for life; devoid of an organized structure; unorganized; lifeness; inanimate; as, all chemical compounds are inorganic substances.
Example Sentences:
(1) Changes in cardiac adenosine triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate (Pi) were followed and intracellular pH (pHi) was estimated from the chemical shift of Pi.
(2) Adenosine diphosphate (ADP) afforded significant protection only at the very highest concentration (5.0 mM); inorganic pyrophosphate (PPi) did not protect against loss of latency at any concentration.
(3) In the liver of albino rats with experimental thyrotoxicosis a study was made of nucleic acids and some indices of phosphorus metabolism: total and inorganic phosphorus, total and acid-soluble phosphorus, phosphorus of RNA, DNA and phosphoproteins.
(4) Resorption of calcium and depositon of inorganic phosphates in the implanted ceramics suggested that ions were being exchanged with the body fluids.
(5) Incubation of I diaphragms with isoproterenol did not significantly increase the concentrations of AMP, IMP or inorganic phosphate, activators of phosphorylase beta activity, nor was there a decrease in ATP and glucose 6-phosphate content, allosteric inhibitors of phosphorylase beta activity.
(6) In general, enzyme activity was strongly reduced by heavy metal inorganic cations; less strongly by organometallic cations, some anions, and certain pesticides; and weakly inhibited by light metal cations and organometallic and organic compounds.
(7) A calcium dependent potassium conductance was probably involved in the slow phase, because it was sensitive to inorganic calcium blockers.
(8) The hypothesis was tested that plaque, as a complex soil comprising microorganisms, cell debris, salivary deposits and other ill-defined organic and inorganic components, would be susceptible to removal by a rinse with high detersive action.
(9) Except for one control group, the other three groups were subdivided into six groups and administered three different kinds of germanium (inorganic germanium, organic germanium, and natural organic germanium) one month before and during dimethylhydrazine treatment, and during dimethylhydrazine treatment, respectively.
(10) It was revealed that the TTH level could change both in the direction of decrease and of elevation; the inorganic phase of the iodine metabolism was reduced and the organic one--elevated.
(11) Iron presented as inorganic ferric or ferrous salts may also be absorbed, though the more soluble ferrous salts are adsorbed much more rapidly.
(12) This paper indicates the tests available for measurement of inorganic lead uptake by the body.
(13) This decrease was associated with a release of lactate and inorganic phosphate during the repetitive periods of reperfusion.
(14) Inorganic mercury as HgSO4 or HgCl2, at dietary levels up to 200 p.p.m.
(15) In conclusion, these data suggest a steady-state kinetic mechanism for KDO8P synthase where P-pyruvate binding precedes that of Ara5P, followed by the ordered release of inorganic phosphate and KDO8P.
(16) A series of inorganic anions varied in their ability to release iron from Fe3+-transferrin-CO3(2-) at pH 5.5, the approximate pH of endosomes where iron release takes place within cells.
(17) Histological changes were similar in inorganic and methyl mercury treated fish except the higher intensity observed in the latter treatment.
(18) We assayed inorganic sulfate by ion chromatography in 49 amniotic fluid samples from pregnancies of 14 to 38 weeks gestation.
(19) strain 4CB1, 4-chlorobenzoate did not accumulate but was converted to inorganic chloride.
(20) The sulfhydryl enzyme malate synthase was inactivated by X-irradiation in air-saturated aqueous solution, in the absence or presence of a variety of additives (thiols, antioxienzymes, typical radical scavengers, inorganic salts, buffer components, substrates, products, analogues).