(n.) A selenide containing two atoms of selenium in each molecule.
Example Sentences:
(1) We described a production of IFN-gamma and TNF-alpha by various subsets of PBL stimulated with 2-phenyl-1,2-benzisoselenazol-3(2H)-one (ebselen) or bis [2-(N-phenyl-carbamoyl)]phenyl diselenide.
(2) SR that had been extensively labeled with the diselenide spin label was resistant to ATPase inactivation by potent oxidants that arise when myoglobin reacts with hydroperoxides.
(3) The riductive scission of a diselenide (selenocystamine) produced by disulfide gives the perselenosulfide, a new compound.
(4) After reaction between ebselen and L(SH)2 the diselenide of ebselen was immediately detected.
(5) 5-Selenium-substituted derivatives (diselenides) or uracil, 2'-deoxyuridine, and 2'-deoxyuridylic acid were synthesized via the addition of methyl hypobromite to the 5,6 double bond, followed by reaction of the adducts with sodium diselenide.
(6) Furthermore, it is likely that a selenol is an intermediate in diselenide formation.
(7) This glutathione oxidase activity required the heterolytic reduction of the diselenide bond, which produced two equivalents of the selenolate derivative selenocysteamine (RSe-), via the transient formation of a selenenylsulfide intermediate (RSe-SG).
(8) The second order rate constants for the reaction of ebselen (0.29 mM-1 min-1), ebselen-glutathione selenosulfide (less than or equal to 0.01 mM-1 min-1), ebselen selenol (2.8 mM-1 min-1) and ebselen diselenide (0.32 mM-1 min-1) with hydrogen peroxide reveal that the selenol is particularly active in this respect.
(9) We tested the antiproliferative effects of Diheptyl Diselenide (DHDSe) on several different human cancer cell lines.
(10) Under these conditions, BSC was partially converted to dibenzyl diselenide (DDS) and phenylmethaneseleninic acid.
(11) No additional cytotoxicity due to the selenium atom was observed, with the exception of diselenide (-SeSe-) compounds.
(12) These observations suggest that electrostatic interactions affect the reductive cleavage of diselenide and selenenylsulfide linkages.
(13) Specificity studies reveal that variation of the N-substituent in the benzisoselenazolone system does not influence cytochrome P-450 inactivation, whereas ebselen derivatives with methylated or glucuronidated selenium moiety as well as diselenides do not convert cytochrome P-450 to P-420.
(14) On the other hand, membranes that had been extensively treated with the diselenide spin label and were then subjected to these peroxide treatments were fully active after mercaptoethanol-mediated cleavage of the thioselenides.
(15) Sodium dodecyl sulfate gel electrophoresis showed that peroxide-mediated crosslinking of ATPase observed in unmodified SR membranes did not occur in the diselenide-modified SR membranes.
(16) The determination of the relative amounts of ebselen selenol and diselenide under typical peroxidase assay conditions implies that the selenol is the predominant molecular species responsible for the glutathione--(70%)--and dithiothreitol--(96%)--dependent peroxidase activity of ebselen.
(17) The most active cytokine inducers were: 2-phenyl-1,2-benzisoselenazol-3(2H)-one (1, ebselen), bis [2-(N-phenylcarbamoyl)]phenyl diselenide (7) and bis (2-[N-(2-pyridyl)carbamoyl])phenyl diselenide (8).
(18) Protein mixed thioselenides formed by reaction of sarcoplasmic reticulum (SR) with diselenide biradical spin labels were quantified by ESR.
(19) The fast formation of the diselenide with L(SH)2 versus the slow formation of the diselenide with GSH accounts for our observation that L(SH)2 is a better cofactor than GSH in the peroxidase activity of ebselen.
(20) Finally the diselenide reacts with a peroxide and ebselen is regenerated.
Organic
Definition:
(a.) Of or pertaining to an organ or its functions, or to objects composed of organs; consisting of organs, or containing them; as, the organic structure of animals and plants; exhibiting characters peculiar to living organisms; as, organic bodies, organic life, organic remains. Cf. Inorganic.
(a.) Produced by the organs; as, organic pleasure.
(a.) Instrumental; acting as instruments of nature or of art to a certain destined function or end.
(a.) Forming a whole composed of organs. Hence: Of or pertaining to a system of organs; inherent in, or resulting from, a certain organization; as, an organic government; his love of truth was not inculcated, but organic.
(a.) Pertaining to, or denoting, any one of the large series of substances which, in nature or origin, are connected with vital processes, and include many substances of artificial production which may or may not occur in animals or plants; -- contrasted with inorganic.
Example Sentences:
(1) The high amino acid levels in the cells suggest that these cells act as inter-organ transporters and reservoirs of amino acids, they have a different role in their handling and metabolism from those of mammals.
(2) These organic compounds were found to be stable on the sorbent tubes for at least seven days.
(3) The main clinical features pertaining to the concept of the "psycho-organic syndrome" (POS) were investigated in a sample of children who suffered from severe craniocerebral trauma.
(4) After 3 and 6 months, blood collected by cardiocentesis using ether anesthesia and then sacrificed to remove CNS and internal organs.
(5) Addition of phospholipase A2 from Vipera russelli venom led to a significant increase in the activity of guanylate cyclase in various rat organs.
(6) For the first time it was organized on the basis of population.
(7) Acceptance of less than ideal donors is ill-advised even though rejection of such donors conflicts with the current shortage of organs.
(8) There is no evidence that health-maintenance organizations reduce admissions in discretionary or "unnecessary" categories; instead, the data suggest lower admission rates across the board.
(9) We conclude that chloramphenicol resistance encoded by Tn1696 is due to a permeability barrier and hypothesize that the gene from P. aeruginosa may share a common ancestral origin with these genes from other gram-negative organisms.
(10) Recovery of CV-3988 from plasma averaged 81.7% for the column procedure and 40% for the organic extraction.
(11) One of the main users is coastal planning organizations and conservation organizations that are working on coral reefs.
(12) Infection with opportunistic organisms, either singly or in combination, is known to occur in immunocompromised patients.
(13) The causative organisms included viruses, fungi, and bacteria of both high and low pathogenicity.
(14) A chronic cannulation procedure is described which allows for sampling vomeronasal organ (VNO) contents repeatedly in freely moving conscious subjects.
(15) Neither Brucella organisms, nor increased numbers of neutrophils could be found in semen samples collected from the experimental animals.
(16) The lineage and clonality of Hodgkin's disease (HD) were investigated by analyzing the organization of the immunoglobulin and T-cell receptor beta-chain (T beta) gene loci in 18 cases of HD, and for comparison, in a panel of 103 cases of B- and T-cell non-Hodgkin's lymphomas (NHLs) and lymphoid leukemias (LLs).
(17) A review is made from literature and an inventory of psychological and organic factors implicated in this pathology.
(18) The authors conclude that H. pylori alone causes little or no effect on an intact gastric mucosa in the rat, that either intact organisms or bacteria-free filtrates cause similar prolongation and delayed healing of pre-existing ulcers with active chronic inflammation, and that the presence of predisposing factors leading to disruption of gastric mucosal integrity may be required for the H. pylori enhancement of inflammation and tissue damage in the stomach.
(19) Data is available to support the early influences of enamel organ epithelium upon a responding mesenchyme in the determination of dental morphogenetic fields (Dryburg, 1967; Miller, 1969).
(20) The four deaths were not related to the injuries of parenchymatous organs.