(v. t.) To free from entanglement; to release from a condition of being intricately and confusedly involved or interlaced; to reduce to orderly arrangement; to straighten out; as, to disentangle a skein of yarn.
(v. t.) To extricate from complication and perplexity; disengage from embarrassing connection or intermixture; to disembroil; to set free; to separate.
Example Sentences:
(1) Research to develop and ensure diffusion of smoking prevention programs must (a) be based on an appreciation of the social, psychological, and biological determinants at each stage in the onset process, (b) disentangle major interactions between program content, participant, provider, and setting factors as they determine impact, and (c) ensure both that diffusion is based on empirically grounded principles and that the process is monitored and its effectiveness evaluated.
(2) Felipe sought on Thursday to disentangle the monarchy from controversy.
(3) Much of the story, however, is doubtful; perhaps now, with Carr's death, it may be possible to disentangle some of the strands of insinuation, legal spin and lies.
(4) The results are discussed in relation to selection and gene flow and provide the basis for laboratory studies to disentangle confounded effects of (1) environmental means and environmental variabilities and (2) allele frequency and heterozygosity, and thus to further test for and determine the nature of any natural selection at particular allozyme loci.
(5) The aim was to analyse trends in mortality from peptic ulcer in Italy between 1955 and 1985, disentangling the role of age, cohort of birth, and period of death.
(6) I think they also believe when people start to look at the practical consequences of disentangling ourselves from this very complicated relationship, then maybe we will think again.” The European media coverage of the UK’s Brexit debate fuels the belief the UK could change its mind.
(7) Since in practice, genetic, nutritional and environmental factors are not readily disentangled, norms for a given study population need to be derived from healthy subjects of similar background and ethnicity.
(8) Coexisting epileptic and psychogenic symptoms being difficult to disentangle patients presenting both may be exposed to unfortunate alternating therapeutic strategies by ambitendent therapists.
(9) The transatlantic backdrop Britain’s attempts to disentangle itself from the EU are confronted with a level of complexity that may be insuperable Meanwhile, on this side of the Atlantic, Britain’s attempts to disentangle itself from the European Union are confronted with a level of complexity that may be insuperable .
(10) Thus, unreported environmental effects common to progeny of individual sires may also be involved in the observed interaction but could not be disentangled from true genotype x environment interaction effects using these data.
(11) But it's a pick'n'mix sort of philosophy that'd take a greater intellect than mine to disentangle.
(12) Arthur MacGregor, archaeologist and recently retired curator of the Ashmolean museum in Oxford, has tried to disentangle the competing claims.
(13) Both strains present a different susceptibility to a unique challenge with the mycobacterium which could be useful to disentangle the immunogenetic components involved, by means of appropriate selection and crosses.
(14) Once Allende took office, Korry sought accommodation with the new government, conceding that expropriations of the telephone and copper concessions (actually begun under Frei) were necessary to disentangle Chile from seven decades of 'incestuous and corrupting' dependency.
(15) Some of the Turkish-backed groups had been asked to disentangle themselves from jihadi groups that are active in parts of the war for the north.
(16) But disentangling a hostile local population from the al-Qaida fighters and leaders who have infiltrated the region will be a hugely difficult task.
(17) Further work is planned using more sophisticated statistical techniques to disentangle the relative contribution of each of these highly intercorrelated factors.
(18) Several alternative methods are made available for disentangling peaks, which can be tried successively on a single peak then each printed out with comments for comparison later.
(19) You don’t have the self-knowledge you think you do.” It took him a few years – until he found himself in another serious relationship – to begin to disentangle what had happened.
(20) Heavy drinking and heavy smoking are often associated; the effects of either alcohol and tobacco on human cancer can not be easily disentangled.
Unbind
Definition:
(v. t.) To remove a band from; to set free from shackles or fastenings; to unite; to unfasten; to loose; as, unbind your fillets; to unbind a prisoner's arms; to unbind a load.
Example Sentences:
(1) Thus, although the fast sodium inactivation process is not required for tonic and use-dependent block of INa by disopyramide, it contributes to the fast phase of block development and unbinding from use-dependent block.
(2) Two calcium antagonistic drugs, nifedipine and mesudipine, were investigated and as a result averaged rate constants of binding and unbinding were evaluated.
(3) Physical theories have been developed to describe many aspects of their conformational behaviour, such as the preferred shapes and shape transformations of closed vesicles, and the shape fluctuations, random-surface configurations, and adhesion and unbinding of interacting membranes.
(4) Assuming a reversible one-to-one binding reaction, the time course of DHO binding and unbinding was analysed under a variety of conditions.
(5) Sanguinarine may produce a K+-like effect upon the Na pump with consequent unbinding of ouabain.
(6) The rate constants for binding and unbinding of ATP were estimated from the dependence of the mean open time on [ATP] and from the Ki.
(7) The rate for unbinding during depolarization was independent of pHo.
(8) We suggest that these conformational changes arise from the unbinding to DNA of certain basic tails of histone(s), and that a competition for DNA binding locations exists upon the reassociation.
(9) These findings suggest than AN-132 has use dependent inhibitory action on the fast sodium channel by binding to the channel mainly during its activated state and that the unbinding rate of the drug during diastole is very slow.
(10) Because in most cases these fit a single exponential with a mean open duration like that of modified channels, we conclude that voltage-dependent toxin unbinding produced a mixed population of unmodified and modified openings.
(11) The extent of the contribution of the process of agonist binding and unbinding to adenylate cyclase activation has not been demonstrated or quantified.
(12) It is interesting that encainide and flecainide unbind slowly (15-20 seconds), whereas lidocaine and moricizine unbind rapidly (0.2-1.3 seconds).
(13) Therefore, sodium channel states regulate the binding and unbinding behaviour of antiarrhythmic drugs.
(14) Such [Ca2+]i-transients in muscle are actually subcellular spatio-temporal events that are determined dynamically by i) diffusional fluxes of Ca2+, ii) by the binding or unbinding of Ca2+ to ligands such as troponin c and calmodulin, and iii) by the various cellular processes, such as release of Ca2+ from sarcoplasmic reticulum, that produce fluxes of Ca2+ across the membranes bounding organelles or the cell.
(15) According to the model, RAC109-I and RAC109-II have significantly different unbinding rate constants for channels when they exist predominantly in rested, activated, or inactivated states, as well as significantly different binding rate constants when channels are activated.
(16) We conclude that binding and unbinding of one molecule of ATP determine the gating of ATP-sensitive K+ channel.
(17) The dissociation rate constant of DHO unbinding remained unchanged (approximately 0.06 s-1).
(18) Estimates of binding and unbinding rate constants for the sodium channel during the action potential plateau and after repolarization were of the same order as previous results obtained using microelectrode methods in vitro.
(19) Increasing the concentration of drug increased the rate of binding but had little or no effect on unbinding, as expected for a simple bimolecular reaction.
(20) Binding and unbinding of MK-801 seems to be possible only if the N-Me-D-Asp-operated channel is in the transmitter-activated state: MK-801 was effective only when applied simultaneously with N-Me-D-Asp, and recovery from MK-801 blockade was speeded by continuous exposure to N-Me-D-Asp [time constant (tau) approximately equal to 90 min at -70 to -80 mV].