(v. t.) To free from entanglement; to release from a condition of being intricately and confusedly involved or interlaced; to reduce to orderly arrangement; to straighten out; as, to disentangle a skein of yarn.
(v. t.) To extricate from complication and perplexity; disengage from embarrassing connection or intermixture; to disembroil; to set free; to separate.
Example Sentences:
(1) Research to develop and ensure diffusion of smoking prevention programs must (a) be based on an appreciation of the social, psychological, and biological determinants at each stage in the onset process, (b) disentangle major interactions between program content, participant, provider, and setting factors as they determine impact, and (c) ensure both that diffusion is based on empirically grounded principles and that the process is monitored and its effectiveness evaluated.
(2) Felipe sought on Thursday to disentangle the monarchy from controversy.
(3) Much of the story, however, is doubtful; perhaps now, with Carr's death, it may be possible to disentangle some of the strands of insinuation, legal spin and lies.
(4) The results are discussed in relation to selection and gene flow and provide the basis for laboratory studies to disentangle confounded effects of (1) environmental means and environmental variabilities and (2) allele frequency and heterozygosity, and thus to further test for and determine the nature of any natural selection at particular allozyme loci.
(5) The aim was to analyse trends in mortality from peptic ulcer in Italy between 1955 and 1985, disentangling the role of age, cohort of birth, and period of death.
(6) I think they also believe when people start to look at the practical consequences of disentangling ourselves from this very complicated relationship, then maybe we will think again.” The European media coverage of the UK’s Brexit debate fuels the belief the UK could change its mind.
(7) Since in practice, genetic, nutritional and environmental factors are not readily disentangled, norms for a given study population need to be derived from healthy subjects of similar background and ethnicity.
(8) Coexisting epileptic and psychogenic symptoms being difficult to disentangle patients presenting both may be exposed to unfortunate alternating therapeutic strategies by ambitendent therapists.
(9) The transatlantic backdrop Britain’s attempts to disentangle itself from the EU are confronted with a level of complexity that may be insuperable Meanwhile, on this side of the Atlantic, Britain’s attempts to disentangle itself from the European Union are confronted with a level of complexity that may be insuperable .
(10) Thus, unreported environmental effects common to progeny of individual sires may also be involved in the observed interaction but could not be disentangled from true genotype x environment interaction effects using these data.
(11) But it's a pick'n'mix sort of philosophy that'd take a greater intellect than mine to disentangle.
(12) Arthur MacGregor, archaeologist and recently retired curator of the Ashmolean museum in Oxford, has tried to disentangle the competing claims.
(13) Both strains present a different susceptibility to a unique challenge with the mycobacterium which could be useful to disentangle the immunogenetic components involved, by means of appropriate selection and crosses.
(14) Once Allende took office, Korry sought accommodation with the new government, conceding that expropriations of the telephone and copper concessions (actually begun under Frei) were necessary to disentangle Chile from seven decades of 'incestuous and corrupting' dependency.
(15) Some of the Turkish-backed groups had been asked to disentangle themselves from jihadi groups that are active in parts of the war for the north.
(16) But disentangling a hostile local population from the al-Qaida fighters and leaders who have infiltrated the region will be a hugely difficult task.
(17) Further work is planned using more sophisticated statistical techniques to disentangle the relative contribution of each of these highly intercorrelated factors.
(18) Several alternative methods are made available for disentangling peaks, which can be tried successively on a single peak then each printed out with comments for comparison later.
(19) You don’t have the self-knowledge you think you do.” It took him a few years – until he found himself in another serious relationship – to begin to disentangle what had happened.
(20) Heavy drinking and heavy smoking are often associated; the effects of either alcohol and tobacco on human cancer can not be easily disentangled.
Unknot
Definition:
(v. t.) To free from knots; to untie.
Example Sentences:
(1) Initially, all attempts to unknot or remove the catheter failed.
(2) "Well…" His delightful press secretary, Lena, starts giggling as her boss tries to unknot himself from this contradiction.
(3) The purpose of this study was to identify possible mechanisms of resistance present in these cells by using human mdr1 and topoisomerase II DNA probes, antibodies to these gene products, and P4 phage unknotting assay for topoisomerase II activities.
(4) The extractable topoisomerase II activity of Bloom's syndrome fibroblasts, as measured by unknotting of page P4 DNA, is much more strongly inhibited by cell growth in medium containing BrdU than is that of normal fibroblasts.
(5) In the present study, we found that nuclear extracts of these sublines (approximately 50- and approximately 140-fold resistant to VM-26) required 2 and 8 times more adenosine 5'-triphosphate (ATP), respectively, to achieve half-maximal stimulation of unknotting activity compared to extracts from the sensitive cells.
(6) In the presence of 500 microM ATP, equimolar concentrations of 2-bromo-dATP, dideoxy-ATP, 2-chloro-dATP, 2-fluoro-dATP, and dideoxy-GTP nucleotide analogues inhibited the unknotting activity of the Topo II enzyme.
(7) Sensitivity of the topo II unknotting assay to inhibition by VP-16 was the same for the parent and all resistant cell lines.
(8) The phage P4-unknotting activity of nuclear extracts decreased 2-fold when AA8 cells entered into the non-cycling state, but there was no difference in sensitivity to amsacrine between log- and plateau-phase nuclear extracts.
(9) Methods are described for accurate measurement of 10-100 ng of unknotted P4 DNA.
(10) Our preliminary results demonstrate remarkable activity of Topo II with specific conversion of knotted form P4 DNA to unknotted form in human kidney cancer cells, YCR and ACHN.
(11) The conditions for the reactions of relaxation, unknotting, decatenation, and catenation were found to be similar to those observed with enzymes from other eukaryotic cells.
(12) The ATP concentration required for equivalent activity in a DNA-unknotting assay is 2- to 8-fold higher in nuclear extracts from drug-resistant cell lines as compared with the parental line.
(13) Several quinolones and antitumor compounds were tested as inhibitors of purified calf thymus topoisomerase II in unknotting, catenation, radiolabeled DNA cleavage, and quantitative nonradiolabeled cleavage assays.
(14) This method check relative Topo II activity with its conversion of knotted form P4 phage DNA to unknotted form.
(15) Regular chromic material was stronger in unknotted tensile strength and fracture load for all gauges.
(16) P4 unknotting assays of the purified nuclear type II topoisomerase in the presence of m-AMSA and VM-26 indicated that the mitochondrial and nuclear enzymes behaved similarly, although the mitochondrial enzyme appeared to be inhibited more strongly.
(17) More than 99% of the inversion products were unknotted rings.
(18) The enzyme can catenate supercoiled DNA molecules, unknot DNA, and cleave double-stranded DNA.
(19) Topoisomerase II activity in nuclear extracts, as determined by the P4 phage DNA-unknotting assay, was more easily detected and measured at lower NaCl concentrations in NCI-H69 than in NCI-H187 cells.
(20) The level of DNA topoisomerase II protein, detected by antibody staining, decreased concomitantly with a general decrease in DNA topoisomerase II unknotting activity, while DNA topoisomerase I activity was not affected.