(1) measurements on solutions of the basic pancreatic trypsin inhibitor (BPTI) was used as input for distance geometry calculations with the programs DISGEO and DISMAN.
(2) The complete three-dimensional structure of the alpha-amylase inhibitor Tendamistat in aqueous solution was determined by 1H nuclear magnetic resonance and distance geometry calculations using the program DISMAN.
(3) Structure calculations with the distance geometry program DISMAN confirmed the presence of the previously identified antiparallel beta-sheets formed by residues 1-5 and 10-14, and by 20-27, 35-39 and 49-55, and established the nature of the connections between the individual beta-strands.
(4) The three-dimensional structure of recombinant desulfatohirudin in aqueous solution was determined by 1H nuclear magnetic resonance at 600 MHz and distance geometry calculations with the program DISMAN.
(5) The techniques used are 1H nuclear magnetic resonance spectroscopy for the data collection, and calculation of the protein structure with the program DISMAN followed by restrained energy minimization with a modified version of the program AMBER.
(6) Translation of the NMR constraints into a three-dimensional structure was carried out with the distance-geometry program DISMAN, followed by restrained energy minimization using CHARMm.
(7) In contrast to this well-defined molecular core, with an average root mean square distance for the polypeptide backbone of 0.8 A for a group of nine DISMAN solutions, no preferred conformation was found for the C-terminal segment 49-65, and a loop consisting of residues 31-36 is not uniquely constrained by the NMR data either.
(8) The backbone folding is determined by distance geometry calculations with the DISMAN program.
(9) In the next two steps DISMAN was used to obtain a group of eight conformers that contain no significant residual violations of the NMR constraints or van der Waals contacts.
(10) Models of the backbone folding were generated by using the DISMAN program and energy refined by using the AMBER program.
(11) The complete protein molecule, including the amino acid side-chains is characterized by a group of nine structures corresponding to the results of the nine DISMAN calculations with minimal residual error functions.
(12) Second, using the program DISMAN, we extended this approach to pentapeptides by extensive sampling of all conformations that are consistent with the local and medium-range NMR constraints.
(13) With an input of 108 intramolecular NOEs and four vicinal 3JHN alpha coupling constants, the three-dimensional structure of cyclosporin A bound to cyclophilin was calculated with the distance geometry program DISMAN, and the structures resulting from 181 converged calculations were energy refined with the program FANTOM.
(14) The structure calculations were performed with the program DISMAN.
Dismay
Definition:
(v. i.) To disable with alarm or apprehensions; to depress the spirits or courage of; to deprive or firmness and energy through fear; to daunt; to appall; to terrify.
(v. i.) To render lifeless; to subdue; to disquiet.
(v. i.) To take dismay or fright; to be filled with dismay.
(v. t.) Loss of courage and firmness through fear; overwhelming and disabling terror; a sinking of the spirits; consternation.
(v. t.) Condition fitted to dismay; ruin.
Example Sentences:
(1) National newspapers and the BBC have joined forces to oppose Hague's secrecy application and on Friday expressed their dismay at the ruling.
(2) I scanned quickly through the available faces: there was one, all scrunched up in dismay about something or other.
(3) Brantly said he was first tested for malaria, but to his dismay, the results came back negative.
(4) Because the housing crisis goes far beyond us Focus E15 mums | Jasmin Stone Read more Annette May, 68, from Lambeth Annette May has watched with mounting dismay as the community fabric of the council estate where she has lived for 44 years steadily unravels.
(5) English speakers are the least optimistic about the chances of avoiding dangerous climate change Out of more than 6,000 self-selecting respondents, many expressed dismay at the slow pace of political action on climate change.
(6) "I feel gutted and dismayed but it's very important that we do everything we humanly can to protect vulnerable young people," Abbott told ABC radio.
(7) Leading figures in the social care sector have rushed to voice dismay at the feud.
(8) Chris Thomson, principal of Brighton, Hove and Sussex sixth form college What dismays me is the emphasis on qualifications rather than education.
(9) For all of this though, the visibility of people living on the streets can be shocking and it makes Perlman’s dismay wholly understandable.
(10) The Spanish family, who abandoned a private equity-backed takeover of National Express last month , was dismayed when National Express subsequently rejected a bid approach from Stagecoach, a rival public transport group.
(12) It was emphatically not, as the Tory right and the dismayed left have already concluded, evidence that Britain remains a fundamentally conservative country.
(13) It said it was "heavily dismayed to learn of the behaviour of Lee Trading with regard to the timely payment of its workers".
(14) I am dismayed at the terrible experience that Wafula Strike had … She is right to bring this matter to the department’s attention and I applaud her bravery for speaking openly about her experience.” The Paralympian condemned Stapleton’s experience: “It’s a real shame that what happened to me is still happening to other people.
(15) It dismays Kirk that Warp moved to London but he's still in touch with them and their releases, effusing particularly about DJ Mujava and "Township Funk".
(16) Suu Kyi's relationship with the generals has reportedly turned sour again In her tireless efforts to secure cooperation from the military, Suu Kyi has repeatedly expressed her appreciation, respect and “genuine” affection for the Tatmadaw (feudal military), which her father founded under Japan’s fascist patronage in December 1942, much to the dismay of many minorities who have borne the brunt of the organisation’s ruthless policies.
(17) Mark Malloch Brown, Britain's foreign office minister for Africa, Asia and the UN, expressed "dismay" over the law's impact on women's rights.
(18) We’ve maintained that commitment, but we have to make sure that we’re spending that money as effectively as possible.” The announcement will dismay some rightwing Conservatives, who fear it could push some wavering voters to Ukip.
(19) Hart respects the Argentinian but was dismayed to be sidelined for him.
(20) To the dismay of the Fostering Network and foster carers, however, there have been no moves to roll out the scheme nationally so that more of the 6,000 young people who leave care annually can opt to stay on in a supportive family environment.