(n.) The act of disposing, arranging, ordering, regulating, or transferring; application; disposal; as, the disposition of a man's property by will.
(n.) The state or the manner of being disposed or arranged; distribution; arrangement; order; as, the disposition of the trees in an orchard; the disposition of the several parts of an edifice.
(n.) Tendency to any action or state resulting from natural constitution; nature; quality; as, a disposition in plants to grow in a direction upward; a disposition in bodies to putrefaction.
(n.) Conscious inclination; propension or propensity.
(n.) Natural or prevailing spirit, or temperament of mind, especially as shown in intercourse with one's fellow-men; temper of mind.
(n.) Mood; humor.
Example Sentences:
(1) In view of its significant effects on drug metabolizing enzymes and clearance mechanisms, it is important to know its disposition characteristics.
(2) Models of the VMT nuclei were constructed to compare their size, shape and disposition across species.
(3) These marked steroid-induced changes in MS responsiveness could not be explained by altered pharmacokinetic disposition of morphine.
(4) The disposition of sulphadimidine (15 mg kg-1 orally) was investigated in six chronic osteoarthritis patients (four slow and two fast acetylators) prior to and 4 days following intra-articular administration of glucocorticoids.
(5) In the present paper, attention has been focused on the role of cytokines and the effects of the acute phase response on drug disposition in disease states (including the effect of anorexia on medicated feed intake and drug bioavailability).
(6) The disposition of radiolabeled cocaine in humans has been studied after three routes of administration: iv injection, nasal insufflation (ni, snorting), and smoke inhalation (si).
(7) Avoidance coping was negatively related to dispositional optimism.
(8) The greatest problems appeared in diagnosing thrombosis of mesenterial vessels and acute appendicitis in cases with the retrocecal disposition of the vermiform process.
(9) Awareness of making dispositional inferences was only weakly correlated with disposition-cued recall.
(10) Current methods of evaluating the bioavailability of drugs with nonlinear disposition kinetics are based on specific pharmacokinetic models in contrast to the more rational model independent (structureless) area under the curve (AUC) and deconvolution methods used in linear pharmacokinetics.
(11) The disposition profiles of a new beta-adrenergic blocking drug, timolol, were investigated at 11 different times in normal individuals after a single oral dose.
(12) In order to compare the disposition of D-galactose and D-glucose in various organs of the rat, we have measured the amount of 14C-galactose and 14C-glucose present in the enteric canal, blood, muscle and liver, 2h.
(13) Leukocyte differentials from 468 emergency room patients were assessed for clinical value by determining their associations with diagnosis, disposition, therapy, and prognosis.
(14) To determine whether basal insulin supplementation in addition to lowering postabsorptive plasma glucose concentration also improves the postprandial pattern of glucose disposition, glucose metabolism after ingestion of a solid mixed meal was assessed in obese patients with NIDDM before and after treatment with ultralente and compared with glucose metabolism observed in nondiabetic subjects.
(15) Particular emphasis was placed on the relative spatial disposition of the tyramine moiety and the additional aromatic ring that occurs in both molecules.
(16) This paper reviews their pharmacologic disposition in man.
(17) The effects of modulation of liver microsomal sulphoxidation on the disposition kinetics of netobimin (NTB) metabolites were investigated in sheep.
(18) The changes in physicochemical properties due to introduction of a benzenesulfonyl group into the hydantoin ring may be responsible for the difference in the disposition between I and II.
(19) The disposition of amiloride was highly dependent on renal function, with higher plasma amiloride concentrations in the elderly reflecting diminished renal function.
(20) The clinical significance of the altered disposition of chloramphenicol is that administration at the usual dosing rate would lead to accumulation of the drug and eventual toxicity.
Humor
Definition:
(n.) Moisture, especially, the moisture or fluid of animal bodies, as the chyle, lymph, etc.; as, the humors of the eye, etc.
(n.) A vitiated or morbid animal fluid, such as often causes an eruption on the skin.
(n.) State of mind, whether habitual or temporary (as formerly supposed to depend on the character or combination of the fluids of the body); disposition; temper; mood; as, good humor; ill humor.
(n.) Changing and uncertain states of mind; caprices; freaks; vagaries; whims.
(n.) That quality of the imagination which gives to ideas an incongruous or fantastic turn, and tends to excite laughter or mirth by ludicrous images or representations; a playful fancy; facetiousness.
(v. t.) To comply with the humor of; to adjust matters so as suit the peculiarities, caprices, or exigencies of; to adapt one's self to; to indulge by skillful adaptation; as, to humor the mind.
(v. t.) To help on by indulgence or compliant treatment; to soothe; to gratify; to please.
Example Sentences:
(1) Work on humoral responses has focused on lysozyme, the hemagglutinins (especially in the oyster), and the clearance of certain antigens.
(2) Reactive metabolites which suppress splenic humoral immune responses are thought to be generated within the spleen rather than in distant tissues.
(3) Our results on humoral and cellular components of immunity in dependence of age, according to SENIEUR protocol admission criteria are presented.
(4) Snakes did not only exhibit the major cell- and humoral-mediated immune functions, but these functions appeared to be linked with the degree of MLR disparity.
(5) These findings show that humoral factors that can inhibit natural killer cell activity in vitro are present in the peripheral blood of patients who have endometriosis; moreover, they suggest that the suppressed natural killer cell activity may allow the development of endometrial cells at ectopic sites.
(6) CGRP at a dose of 3 micrograms caused a small rise in aqueous humor protein concentration.
(7) While mindful of the potential difficulties which attend its introduction into the treatment situation there is an attempt to balance this position through a consideration of the appropriate conditions and modes of operation under which a humor-enriched approach may be efficacious.
(8) The changes in the bone and in calcium metabolism during cisplatin or bisphosphonate administration is reported in a 50-year-old patient with esophageal carcinoma who had humoral hypercalcemia of malignancy (HHM).
(9) In this respect, its effects are very similar to those of pooled rhesus monkey aqueous humor during perfusion of rhesus monkey eyes.
(10) Patients with primary hypogammaglobulinaemia have previously been thought not to be more susceptible to Salmonella infection but a combination of low gastric acidity and impaired humoral immunity may predispose them to such infection.
(11) The appearance in aqueous humor of selected metabolites of arachidonic acid metabolism at various times was correlated with the influx of protein and myeloperoxidase activity in the iris-ciliary body.
(12) The development of this arthritis was accompanied by the expression of cell-mediated and humoral immunity to the immunizing antigen.
(13) The steps in the model are the drug elimination rate in the precornea and anterior chamber, the rate of drug dissolution, the rate of drug penetration into the cornea, and the rate of drug transport into the aqueous humor.
(14) (4) The data support other evidence for declining cellular and humoral immunity in aging man.
(15) The pharmacokinetic parameters, apparent absorption, and elimination rate constants, of phenylephrine and the prodrug were determined from aqueous humor concentration-time and mydriasis-time profiles.
(16) Much has been learned about the complexity of the local, humoral and nervous factors regulating the normal behavior of the skin blood vessels, and many studies have addressed how this knowledge might relate to the causation of primary Raynaud's disease.
(17) Modern analytical techniques allow their detailed analysis in terms of the humoral antibody responses and afford the possibility of the future development of control and disease management procedures tailored to each individual host-parasite system.
(18) Intensive humoral immunity was observed to develop in 86% of vaccines, this genic.
(19) Chemotactic activity in the aqueous humor is found in both CVF-treated and control rabbits 20 hours after intravitreous LPS.
(20) If beta-blockage does not cause lowering of aqueous humor secretion, in itself responsible for the maintenance of intraocular pressure, what is the mechanism of action?